Surgical treatment of osteonecrosis of the jaw with the use of platelet-rich fibrin: a prospective study of 15 patients

Nørholt, Sven Erik; Hartlev, Jens

doi:10.1016/j.ijom.2016.04.010

Cited by 65 publications

(39 citation statements)

References 21 publications

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“…11,47 For quantitative analysis 13 articles were included, 9 articles about third molar 8, 25, 26, 28, 29, 32, 48-50 , 2 articles about sinus lift 35, 38 and 2 articles about dental implants 46, 51 . Seventeen articles were excluded and the reasons for exclusion were as follows: 4 non-randomized controlled clinical trial 52-55 ; 4 studies which outcomes of interest were not reported [56][57][58][59] ; 2 studies that used other PRF protocol 60,61 ; 1 study which did not test PRF 62 ; 1 retrospective study 63 ; 2 prospective studies 64,65 ; 1 study that used the same patients sample as other studies 66 ; 1 full text was not found 67 ; and 1 study was written in persa and not translated 68 . The value of Kappa was 0.84, thus it was considered an excellent agreement.…”

Section: Resultsmentioning

confidence: 99%

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Canellas

Medeiros

Figueredo

et al. 2019

International Journal of Oral and Maxillofacial Surgery

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The effect of platelet-rich fibrin (PRF) in enhancing the healing after oral surgical interventions is still a matter of debate. The purpose of this study was to identify instances where PRF has been shown to be effective in oral surgical procedures. A comprehensive literature search was performed up to 2017 on PubMed/MEDLINE, Cochrane Library, Web of Science, Scopus and LILACS databases and grey literature. The full-text of potentially relevant studies were reviewed and only randomized clinical trials (RCTs) were included. A total of 559 studies were found, of which 30 were included for qualitative analysis and 13 for quantitative analysis. Three review authors assessed the risk of bias independently. The available literature suggests that PRF has a positive effect in improving alveolar preservation on extraction sockets and around dental implants. The qualitative analysis showed a significantly better effect of PRF in promoting bone regeneration for alveolar cleft reconstruction. The meta-analysis for third molar surgery showed a decrease in prevalence of alveolar osteitis. PRF increased implant stability 1 week and 1 month after surgery (P=0.0005 and 0.0003). Due to the lack of studies with low risk of bias and a limited number of patients available, further RCTs are needed to confirm these results.

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Section: Resultsmentioning

confidence: 99%

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Canellas

Medeiros

Figueredo

et al. 2019

International Journal of Oral and Maxillofacial Surgery

View full text Add to dashboard Cite

show abstract

“…The present literature review had several limitations, especially a reduced number of randomized studies [49][50][51] . Amongst other limitations, 50% of the studies had small samples, consisting of one to two patients, two studies were comparative and two studies had a series of control patients 52,53 .…”

Section: Discussionmentioning

confidence: 99%

Fibrin Rich in Leukocytes and Platelets L-PRF and Bisphosphonate-Induced Osteonecrosis: We Need to Advertise Now

Faria¹,

Cabral²,

Castro³

et al. 2019

IJTSRD

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The American Association of Oral and Maxillofacial Surgeons (AAOMS) reported in 2004 a new pathology that causes osteonecrosis in the Maxillomandibular complex. The condition was named Bisphosphonate-related osteonecrosis of the jaw (BRONJ), and later renamed by medication related to jaw osteonecrosis due to the appearance of severe alveolar bone loss in the Maxillomandibular complex resulting from the use of different drugs other than Bisphosphonates. Odontology, especially oral surgery, a field concerned with new biotechnologies, has been introducing innovations in tissue engineering. Oro-maxillofacial reconstruction is of great interest to current oral and maxillofacial surgeons, as part of the search for strategies in bioengineering and biomaterials, a major promoter of bio-dental research in our times. In order to verify the scientific evidences to analyse the effectiveness of leukocyte and platelet rich fibrin (L-PRF) on bone neoformation in Maxillomandibular complex's surgical procedures, a search for qualified articles was conducted in the Medline (PubMed), Embase and Cochrane Central Register of Controlled Trials databases. The works analysed were published from 2013 to 2018. This review concludes that the use of platelet rich fibrin (L-PRF) is significant in the complete healing of the lesion in short postoperative periods and in the resolution of the treatments, reducing the need for postoperative re-interventions, resulting in lower morbidity for the patients.

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“…The patient with persistent bone exposure had grade III ONJ lesion before the surgery. The use of PRF in the surgical treatment of grade II and III ONJ may be a contributing factor to recovery [14,15].…”

Section: Discussionmentioning

confidence: 99%

Bisphosphonate-related osteonecrosis of the jaw in a 66-year-old female – Case report

Gawęda¹,

Czerkies²,

Trzaskowska³

et al. 2017

J Pre Clin Clin Res.

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Bisphosphonate-related osteonecrosis of the jaws is an increasingly common side-effect of bisphosphonate treatment of malignant cancer of the osseous tissue. Necrotic foci of the bone with secondary inflammation are typical of the condition. The treatment is symptomatic and depends on the severity of the disease. The case is presented of BRONJ in a 66-year-old, occupationally-active female patient who had undergone implant-prosthetic treatment, and whose quality of life deteriorated significantly due to the symptoms of the disease. Bisphosphonate-related osteonecrosis of the jaw is treated conservatively at the initial stages of the disease, and surgical treatment should be avoided. Thorough oral hygiene and irrigations with chlorhexidine solution, supported by guided antibiotic therapy, are recommended. In severe cases, surgical sequestrotomy of the inflammatory foci, aimed at inhibiting or decelerating the course of the disease, is necessary.

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Surgical treatment of osteonecrosis of the jaw with the use of platelet-rich fibrin: a prospective study of 15 patients

Cited by 65 publications

References 21 publications

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Platelet-rich fibrin in oral surgical procedures: a systematic review and meta-analysis

Fibrin Rich in Leukocytes and Platelets L-PRF and Bisphosphonate-Induced Osteonecrosis: We Need to Advertise Now

Bisphosphonate-related osteonecrosis of the jaw in a 66-year-old female – Case report

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