Surgical Treatment of Phyllodes Tumor of the Breast with the Trend

Huang, Cheng Chiao; Liu, Tsang Pai; Cheng, Shih‐Ping; Chang, Yuan

doi:10.1016/j.jecm.2014.08.002

Cited by 10 publications

(5 citation statements)

References 24 publications

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“…From these 4183 studies, 3983 were excluded (based on the title), leaving 200 studies for full text analysis. Among these, 184 studies did not meet the inclusion criteria or did not provide sufficient data regarding the study variables, and two focused on the same population within the same institution [35,47]. Therefore, 184 studies were excluded resulting in 16 selected studies for methodological validity assessment.…”

Section: Resultsmentioning

confidence: 99%

Width of margins in phyllodes tumors of the breast: the controversy drags on?—a systematic review and meta-analysis

Toussaint

Piaget-Rossel

Stormacq

et al. 2020

Breast Cancer Res Treat

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Purpose Phyllodes tumors (PT) of the breast are rare fibroepithelial neoplasms. Information is controversial in the literature regarding to the optimal surgical management. Most studies suggested margins of at least 10 mm while some recent studies suggested narrower margins without an increased risk of local recurrences (LR) and distant metastases (DM). The objective of this systematic review was to identify and compare studies that assessed these different practices. Methods A systematic review was performed through five databases up to April 2019. Studies exploring the association between the width of margins, subtypes of PT, and the LR and DM rates were considered for inclusion. A statistical model for analyzing sparse data and rare events was used. Results Thirteen studies met eligibility criteria and were selected. Considering a threshold of 10 mm (margins < 10 vs margins ≥ 10 mm), the 5-year incidence rate of LR was estimated to be 5.22 vs. 3.63 (diff. −1.59) per 100 person-years for benign PT, 9.60 vs. 7.33 (diff. −2.27) for borderline PT, and 28.58 vs. 21.84 (diff. −6.74) for malignant PT. For DM, it was estimated to be 0.88 vs. 0.86 (diff. −0.02) for benign PT, 1.61 vs. 1.74 (diff. 0.13) for borderline PT, and 4.80 vs 5.18 (diff. 0.38) for malignant PT. The data for a threshold of 1 mm were not sufficient to draw any conclusions. Conclusion Irrespective of tumor grade, we found that DM was a rarer event than LR. Malignant PT had the highest incidence rate of LR and DM. This meta-analysis found a clear association between width of margins and LR rates. Whatever the tumor grade, surgical margins ≥ 10 mm guaranteed a lower risk of LR than margins < 10 mm. On the other hand, the width of margin did not influence the apparition of DM.

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Section: Resultsmentioning

confidence: 99%

Width of margins in phyllodes tumors of the breast: the controversy drags on?—a systematic review and meta-analysis

Toussaint

Piaget-Rossel

Stormacq

et al. 2020

Breast Cancer Res Treat

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“…In (4) study, the LR rates increased from benign (8%; range, 6-9%) to borderline (13%; range, 11-16%) to malignant (18%; range, 14-21%) PTs. The lower limit of the pooled OR of the malignant versus the borderline PTs was close to 1.00 (OR 1.28; 95% CI 1.05-1.55).…”

Section: Discussionmentioning

confidence: 80%

“…Associations between frequently used pathologic parameters and the risk of LR also were scrutinized in the study of (4) where The pooled results showed that an increased risk of LR mitoses was significantly associated with 10/10 HPF or higher ( (11) noted that mitosis, cellular atypia, stromal overgrowth, and tumor necrosis were predictive of disease-free survival on univariate analysis, but the significance disappeared on multivariate analysis for all types of phyllodes tumors.…”

Section: Discussionmentioning

confidence: 99%

Local Recurrence of Phyllodes Tumors of the Breast : A Meta-Analysis

Mohammed

Othman

Eltaib

et al. 2021

Ain Shams Medical Journal

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“…[4] Due to the fact that sharp distinction between benign, borderline and malignant PT is sometimes difficult to be obtained, predictive factors for local recurrence or distant metastases are hard to be well established. [11] However, the gold standard in treating these tumors remains a complete surgical resection. [4] In different studies local recurrence is seen in 8-40% of cases while distant metastases are reported in 0-21% of cases, depending on the proportion of aggressive histopathological types of tumors comprised in each study.…”

Section: Discussion Discussionmentioning

confidence: 99%

“…These kind of tumors are associated with a higher risk of recurrence and evolution towards an aggressive disease. [10,11] We present the case of a 69 year old patient who presented for the aparition of a large mass deforming the left breast in whom a total mastectomy was performed. The histopathological findings revealed a malignant Phyllodes tumor.…”

Section: Introduction Introductionmentioning

confidence: 99%

Total mastectomy for phyllodes malignant tumor in an elderly patient

Bacalbaşa¹,

Bălescu²,

Brasoveanu³

2014

JTMR

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Phyllodes tumors are rare neoplasms accounting for less than 1% of all breast malignancies. Under this generic name more histopathological subgroups are included. Malignant phillodes tumors represent less than a quart of all phillodes tumors and are associated with a more aggressive biological behaviour with a higher tendency to both local and distant metastases. One of the most important prognostic factors in order to increase the overall ssurvival in these cases remains a wide excision of the primary tumor. We present a case of a 69 years old patient diagnosed with a large tumor deforming the left breast in whom the results of the punction-biopsy revealed a Phylodes malignant tumor. A total mastectomy was performed.

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Surgical Treatment of Phyllodes Tumor of the Breast with the Trend

Cited by 10 publications

References 24 publications

Width of margins in phyllodes tumors of the breast: the controversy drags on?—a systematic review and meta-analysis

Width of margins in phyllodes tumors of the breast: the controversy drags on?—a systematic review and meta-analysis

Local Recurrence of Phyllodes Tumors of the Breast : A Meta-Analysis

Total mastectomy for phyllodes malignant tumor in an elderly patient

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