Surgical Treatment of Primary Cardiac Tumors

Kamiya, Hiroyuki; Yasuda, Tamotsu; Nagamine, Hiroshi; Sakakibara, Naoki; Nishida, Satoru; Kawasuji, Michio; Watanabe, Go

doi:10.1253/jcj.65.315

Cited by 77 publications

(23 citation statements)

References 21 publications

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“…If the hospital is famous for the treatment of malignant diseases, the number of cases with primary or secondary malignant cardiac tumors may increase. Mortality in cases of primary benign tumor is low [ 12 – 14 ]. However, < 50% of patients with primary malignant cardiac tumors were alive by the end of the first year after diagnosis, with a sharp decrease in survival for sarcoma patients [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

Primary and metastatic cardiac tumors: echocardiographic diagnosis, treatment and prognosis in a 15-years single center study

Nomoto

Tani

Konda

et al. 2017

J Cardiothorac Surg

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BackgroundThe frequency of primary cardiac tumors is rare at about 0.3% by autopsy. Our objective was to investigate the characteristics and locations of cardiac tumors and to provide a prognostic analysis in our hospital.MethodsWe collected data on 95 patients with echocardiographic diagnosis or detection of cardiac tumors in a prospective analysis from 1999 to 2014. The median follow-up period was 43 months (0.5–183 months).ResultsThe subjects included 56 men and 39 women with a mean age of 65 years. Clinical diagnosis revealed primary tumors in 61 patients (64%) and secondary metastatic tumors in 34 patients (36%). In the 61 patients, 41 patients (67%) underwent surgery and tissue samples were obtained. Of these 41 patients, benign tumors were found in 30 cases (73%). One patient (2%) was diagnosed with thrombus. Among the benign tumors, myxoma (67%) was the most common type followed by papillary fibroelastoma (23%). The most common site was the left atrium (35%) followed by the right atrium (25%). Primary malignant tumors were diagnosed in 10 cases (24%), including 6 angiosarcomas, 3 lymphomas, and 1 leiomyosarcoma. The diagnostic accuracy of echocardiography was 80%. The patients with benign tumors were all alive at the end of the follow-up period. In contrast, 7 patients with malignant tumors died (70%) (p < 0.0001).ConclusionsOur data is in line with previous literature. Our study also suggests the necessity of extending our knowledge of the characteristics of cardiac tumors for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Primary and metastatic cardiac tumors: echocardiographic diagnosis, treatment and prognosis in a 15-years single center study

Nomoto

Tani

Konda

et al. 2017

J Cardiothorac Surg

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“…The presentations may involve symptoms of superior vena cava obstruction or cardiac tamponade or myocarditis [5]. It is evident from this case that investigation of cardiac masses is required with imaging studies such as cardiac MR and biopsy to determine the origin and aetiology to guide multidisciplinary management.…”

Section: Discussionmentioning

confidence: 99%

Right Atrial Cardiac Thymoma with Superior Vena Cava Extension

Ganapathipillai¹,

Jaltotage²,

Gupta³

et al. 2018

Clin Res Trial

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We report a rare presentation of invasive thymoma in an otherwise well 83 year old lady. Echocardiography, cardiac MR and PET imaging revealed a right atrial mass extending to and partially obliterating superior vena cava. The differentials were cardiac lymphoma, sarcoma, metastatic tumour or thymoma. A transvenous biopsy of the right atrial mass was performed under transoesophageal echocardiography guidance. The pathology showed invasive thymoma type B3. The patient was managed with steroids, oral anticoagulation and radiotherapy.

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“…Bi-atrial approach allows the inspection of the four cardiac chambers, limits manipulation of the mass, and facilitates the complete excision of the tumor. Thus, this should be used when a patient has myxomas in multiple cardiac chambers or exhibits a definite familial nature[11]. Alternatively, heart transplantation can be considered as an alternative therapy to prevent recurrence when the primary or recurrent myxoma is too difficult to be removed[12].…”

Section: Discussionmentioning

confidence: 99%

Familial cardiac myxoma with multifocal recurrences: a case report and review of the literature

Cao

Zhu

et al. 2011

Journal of Biomedical Research

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We report a case of myxoma with multiple recurrences in both the atrium and ventricle in a 26-year-old woman five years after the surgical removal of left atrial myxoma. Her 52-year-old mother had a similar medical history. To our knowledge, this was the first familial case who suffered multifocal cardiac myxoma recurrences without any sign of the myxoma complex. Based on our understanding of the mechanism of recurrence, the approaches to prevent the recurrence, and markers to predict recurrence, we propose that multifocal recurrences, as reported herein, may result from a combination of familial predisposition and multifocal onset. The bi-atrial surgical approach and transesophageal echocardiography are preferred for patients with recurrent cardiac myxomas, especially for those with multiple recurrences and familial myxoma. Immunological and genetic screenings may help to identify family members at risk for developing this disease.

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Surgical Treatment of Primary Cardiac Tumors

Cited by 77 publications

References 21 publications

Primary and metastatic cardiac tumors: echocardiographic diagnosis, treatment and prognosis in a 15-years single center study

Primary and metastatic cardiac tumors: echocardiographic diagnosis, treatment and prognosis in a 15-years single center study

Right Atrial Cardiac Thymoma with Superior Vena Cava Extension

Familial cardiac myxoma with multifocal recurrences: a case report and review of the literature

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