Surgical treatment of primary cardiac tumors in the contemporary era: A single‐centre analysis

Matteucci, Matteo; Ferrarese, Sandro; Mantovani, Vittorio; Ronco, Daniele; Torchio, Federica; Franzosi, Cinzia; Marazzato, Jacopo; Ponti, Roberto De; Lorusso, Roberto; Beghi, Cesare

doi:10.1111/jocs.15813

Cited by 10 publications

(6 citation statements)

References 22 publications

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“…Although surgical management is the treatment of choice for primary cardiac sarcoma, the long - term prognosis is poor. 11 The median survival time of these patients was between 6 and 12 months. Advanced age and advanced disease with metastasis are independent risk factors for poor prognosis.…”

Section: Discussionmentioning

confidence: 95%

Primary Cardiac Sarcoma, Diagnostic and Therapeutic Challenges in Resource Limited Setting: Case Report

Mulisa,

Bekele,

Woldemichael

et al. 2024

IMCRJ

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Left atrial masses are commonly caused by atrial myxomas and metastatic tumors. Primary cardiac sarcomas are rare. Patients present with symptoms related to the tumor location. There are only a few case reports on this rare disease. We report the case of a 17 years old male patient presented with shortness of breath for 2-month duration. Echocardiography revealed a left atrial mass that was later surgically excised and histopathology confirmed a primary cardiac sarcoma. We discuss the diagnostic and therapeutic challenges encountered in the management of this rare disease. To the best of our knowledge, this is the first case reported in East Africa.

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Section: Discussionmentioning

confidence: 95%

Primary Cardiac Sarcoma, Diagnostic and Therapeutic Challenges in Resource Limited Setting: Case Report

Mulisa,

Bekele,

Woldemichael

et al. 2024

IMCRJ

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“…Primary cardiac tumors are rare with an estimated incidence of 1,380/100 million individuals in the general population ( 1 ). Benign tumors account for the majority of them and have a favorable surgical prognosis, while malignant cardiac tumors are usually aggressive and are associated with poor outcome ( 2 , 3 ). The atrial is a common site where cardiac tumor occurs.…”

Section: Introductionmentioning

confidence: 99%

Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years

Wang

Jiang

et al. 2023

Front. Surg.

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BackgroundPrimary atrial tumors are relatively rare and predominantly benign. However, some atrial tumors may be malignant and are associated with poor outcome. Currently, it is hard to determine the malignance of atrial tumors by preoperative clinical presentation or by echocardiography. We aimed to report the difference in the clinical characteristics of patients with benign and malignant atrial tumor.MethodsThis was a single-center retrospective study. A total of 194 patients with primary atrial tumor admitted to our center between 2012 and 2021 were included. The clinical characteristics of patients with benign and malignant tumor were compared.ResultsBenign and malignant tumor accounted for 93% (n = 180) and 7% (n = 14) of the total patients, respectively. Malignant atrial tumor tended to occur in younger patients (P < 0.05), was more likely to be located at the right atrium (P < 0.05), and tended to attach to the atrial wall or valve instead of the atrial septum. Fever symptoms were more common in patients with malignant tumors than in patients with benign tumors (P < 0.05). Compared to benign tumor, patients with malignant atrial tumor also demonstrated higher rates of fever, lower rates of increasing fibrinogen, increased blood glucose (P < 0.05), significantly longer prothrombin time, and lower prothrombin activity (P < 0.05). Patients with malignant primary atrial tumor had higher mortality rate, tumor metastasis rate, and tumor recurrence rate than patients with benign primary atrial tumor (P < 0.05).ConclusionWe compared the clinical characteristics of patients with benign and malignant atrial tumor. These findings provide valuable information to preoperatively determine the malignance of atrial tumor and thus guide surgical treatment.

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“…Nevertheless, almost nothing is known on the mortality and survival rates of PMCTs currently, particularly in different age and treatment groups. A small number of other studies which have examined PMCTs survival in the US have not reported death rates by either age or therapy ( 12 - 15 ). Older ages are often associated with higher mortality and poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

Age and treatment disparities in survival of primary malignant cardiac tumors: an analysis of over 40 years and 500 patients

Wang,

Kang,

Zhang

et al. 2023

J Thorac Dis

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Background Primary malignant cardiac tumors (PMCTs) are rare and tend to have a poor prognosis, due to their aggressive biological behavior and the inadequate expertise with the disease. This article compares the survival of patients with PMCT subtypes in the United States across age and treatment groups. Methods Data of 529 patients diagnosed with PMCTs were analyzed. Chi-squared test was used to assess signiﬁcance of the differences between proportions in demographic and tumor characteristics by age and treatment. Cox regression analysis was used to estimate survival from the Surveillance, Epidemiology, and End Results (SEER) follow-up data. Results Survival rates for PMCTs differed significantly between age groups, with patients younger than 20 years surviving significantly longer than those older than 80 years. The median survival times of all patients with PMCTs were 22.5, 11, 5, and 1 month for ages less than 20, 20–50, 51–80, and greater than 80 years, respectively (global log-rank P=0.0026). In the treatment cohort, for all tumors [hazard ratio (HR) 1.52, P<0.001], sarcomas (HR 1.83, P=0.002), and other tumors (HR 2.24, P=0.017), survival was lower in patients who did not receive treatment than in those who received only surgery. Survival after diagnosis of sarcoma was lower in patients who received radiotherapy only than in those who received surgery only (HR 1.49, P=0.046). However, there was no significant association between treatment and survival for lymphoma and mesothelioma. Conclusions This study confirms that PMCTs have limited treatment options and poor patient survival, especially for elderly patients and patients who receive no treatment. And patients with PMCTs of any age, whether treated or not, have poor survival rates. Techniques for early diagnosis and treatment may be necessary. Surgical treatment should have a higher priority for future treatment of patients with sarcomas.

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Surgical treatment of primary cardiac tumors in the contemporary era: A single‐centre analysis

Cited by 10 publications

References 22 publications

Primary Cardiac Sarcoma, Diagnostic and Therapeutic Challenges in Resource Limited Setting: Case Report

Primary Cardiac Sarcoma, Diagnostic and Therapeutic Challenges in Resource Limited Setting: Case Report

Clinical characteristics of primary atrial tumor and their diagnostic value: A retrospective study of 10 years

Age and treatment disparities in survival of primary malignant cardiac tumors: an analysis of over 40 years and 500 patients

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