Surgical Treatment of Pulmonary Disease Due to Mycobacterium kansasii

Zvetina, James R.; Neville, William E.; Maben, Hayward; Langston, Hiram T.; Correll, Noble O.

doi:10.1016/s0003-4975(10)65071-0

Cited by 11 publications

(3 citation statements)

References 8 publications

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“…Several retrospective case series have been published reporting surgical outcomes in patients with NTM–PD,303–322 the largest involving 236 patients 307. Surgical experience is greatest with MAC-pulmonary disease, but M. abscessus complex,307 M. kansasii 319 and M. xenopi –PD312 have also been the subject of moderate-size studies (32, 35 and 57 patients, respectively). The available data suggest that surgery can be an important adjunct to antimicrobial treatment in carefully selected cases.…”

Section: Section 12d: What Antibiotic Regimen Should Be Used To Treatmentioning

confidence: 99%

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Haworth

Banks

Capstick

et al. 2017

Thorax

615

679

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Section: Section 12d: What Antibiotic Regimen Should Be Used To Treatmentioning

confidence: 99%

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Haworth

Banks

Capstick

et al. 2017

Thorax

615

679

View full text Add to dashboard Cite

“…A preliminary report was made on 35 of these patients. 9 Lobectomy was performed in 30 patients, lung resection in eight patients, pneumonectomy and wax-pack plombage in five patients each, thoracoplasty in four patients, and one patient had decortication. The indications for surgery were: residual cavity, medical failure, or both.…”

Section: Treatmentmentioning

confidence: 99%

Clinical features and follow up of 302 patients with Mycobacterium kansasii pulmonary infection: a 50 year experience

Maliwan

Zvetina

2005

Postgraduate Medical Journal

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Aims: To analyse clinical features and treatment outcomes of patients with pulmonary Mycobacterium kansasii infection treated at Hines VA Hospital between 1952 and 1995, and followed up until 2003. Findings: 302 patients were confirmed to have M kansasii pulmonary infection; diagnosis was not made until death in 2%. The average age was 50 years old; 76% were white; all were men. Productive cough, dyspnoea, and chest pain were common; 16% were asymptomatic. Right sided, apical or subapical, thin walled cavitary infiltrate was the characteristic radiological feature. Heavy smoking, chronic obstructive pulmonary disease, alcoholism, peptic ulcer disease, coronary artery disease, prior tuberculosis, psychosis, prior pneumonia, and immunocompromising conditions were prevalent. Average follow up was 10 years and 2 months. PPD was positive in 58% of 179 tested. Two thirds of the patients required only first line drugs. Fourteen per cent required surgical intervention, none after 1977. Spontaneous resolution occurred in 1%. Aspergillosis developed in 4%. Bronchogenic carcinoma coexisted with M kansasii infection in 6% and followed it in 4%. Extrapulmonary malignancy coexisted with the infection in 4% and followed it in 6%; most involved head and neck. Eleven per cent of 224 deaths were attributed to M kansasii. Outcomes were affected by comorbidity, treatment compliance, rifampicin use, and extent of infection. Conclusions: Prognosis of M kansasii pulmonary infection is good if diagnosed and treated early, together with control of underlying conditions. Clinicians should be aware of atypical radiological manifestations of the disease when coexisting with other pulmonary or immunocompromising conditions. T he role of Mycobacterium kansasii as an infecting organism was not recognised until the early 1950s. M kansasii infection shares many clinical aspects with tuberculosis (TB). However, M kansasii infection contrasts with TB by being non-contagious, more associated with underlying diseases, and having a definite geographical distribution-that is, in southern and central USA.1-4 In a non-endemic area, a higher incidence of M kansasii isolates was found among HIV positive persons, and more predisposing medical conditions were found among HIV negative persons.5 While the prevalence of TB has decreased in the past 20 years, those of non-tuberculous mycobacterial infections including M kansasii have been increasing worldwide. As a positive sputum culture for M kansasii may only reflect colonisation, strict criteria have been developed for the diagnosis of pulmonary M kansasii infection to exclude a mere colonisation. Varying findings on M kansasii pulmonary infection were reported from cancer treatment centres, HIV treatment centres, TB centres, mining company TB clinics, and pulmonary departments. We present here data analysis of the largest patient population with the longest follow up, hopefully to confirm prior findings and to help resolve some of the conflicting conclusions. METHODSThis is a retrospective study of M kans...

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“…Dr Langston became a leading expert in the surgical management of tuberculosis. 3,4 He insisted on preoperative bronchoscopy to exclude endobronchial tuberulosis (a contraindication to resection), as well as a precise and clear bronchogram to define the exact anatomy of the disease and to outline normal lung tissue. Dr Langston was steadfast in his regimen of only carrying out resection when he knew that he could have a favorable outcome and control the disease.…”

mentioning

confidence: 99%

Historical perspectives of The American Association for Thoracic Surgery: Hiram T. Langston (1912–1992)

Faber

D’Amico

2012

The Journal of Thoracic and Cardiovascular Surgery

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Surgical Treatment of Pulmonary Disease Due to Mycobacterium kansasii

Cited by 11 publications

References 8 publications

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)

Clinical features and follow up of 302 patients with Mycobacterium kansasii pulmonary infection: a 50 year experience

Historical perspectives of The American Association for Thoracic Surgery: Hiram T. Langston (1912–1992)

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