Surgical treatment of stage I and II oral squamous cell carcinomas: analysis of causes of failure

Shingaki, Susumu; Kobayashi, Takanori; Suzuki, Ichirô; Kohno, Masaki; Nakajima, Tamio

doi:10.1016/0266-4356(95)90043-8

Cited by 34 publications

(21 citation statements)

References 27 publications

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“…Clearly, assessing the risk of regional metastatic disease based on the clinical and histologic characteristics of the primary tumor is difficult. The decision to observe a patient who has a clinically uninvolved neck is made even more questionable due to the trend toward performing less morbid selective and functional neck dissections [35,[46][47][48]. Radiation therapy may be as effective as surgery in controlling micrometastases [49]; however, surgery provides for histopathologic examination of the LNs, and accurate staging.…”

Section: Controversies In the Management Of The N0 Lymphatic Basin Fomentioning

confidence: 98%

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Sentinel node biopsy for squamous cell carcinoma of the head and neck

Civantos

Zitsch

Bared

et al. 2008

Journal of Surgical Oncology

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The clinical utility of sentinel node biopsy for melanoma has led multiple investigators to apply this approach to other cutaneous malignancies as well as to early cancers of the upper aerodigestive tract. Data are most extensive for oral cancer. A multi-institutional pathologic validation trial for selected oral cancers provided negative predictive values of 96%. Subsequent trials should document clinical follow-up. This technique may ultimately play a wider role in the management of mucosal cancers.

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Section: Controversies In the Management Of The N0 Lymphatic Basin Fomentioning

confidence: 98%

“…For oral cavity cancer, the 20-40% risk of occult metastases [44][45][46][47] must be weighed against the morbidity of dissecting necks that are not truly involved. A better diagnostic technique is needed to identify subclinical cervical metastases and guide the treatment of these patients.…”

Section: Controversies In the Management Of The N0 Lymphatic Basin Fomentioning

confidence: 99%

Sentinel node biopsy for squamous cell carcinoma of the head and neck

Civantos

Zitsch

Bared

et al. 2008

Journal of Surgical Oncology

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“…The risk of palpably occult metastases is to a large extent dependent on the size and site and other characteristics of the primary tumor [1,2]. For most T1-3 oral, oropharyngeal and supraglottic tumors this risk of occult metastases is in the range of 20-50% with significant differences between different sites and studies [3,4]. In many head and neck primaries not only the ipsilateral site of the neck is at risk, but the contralateral site has a significant risk to harbor metastases as well, especially when the primary has grown close to or extends over the midline.…”

Section: Introductionmentioning

confidence: 99%

Imaging of lymphadenopathy in the neck

2001

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Imaging is playing a major role in the assessment of cervical lymphadenopathy. In infectious disease, the assessment of abscess formation and the relation of the abscess to surrounding vital structures is crucial for its management. In head and neck malignancies, imaging can be helpful for staging. Imaging of the neck for the assessment of nodal metastases can be used to detect occult metastases or to assess operability of palpable metastases. The detection of small occult metastases has limitations, as micrometastases cannot be depicted; however, imaging can fulfill a role in diminishing the risk of occult metastases, and thus influence management. For this purpose a very sensitive technique is necessary. The currently used radiological criteria are not sensitive enough to accomplish enough reduction of the risk of occult metastases; therefore, more sensitive CT and MRI criteria, but especially ultrasound-guided aspiration, should be employed to assess the clinically negative neck.

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“…However, controversies exist on the management of the neck in clinically node-negative neck (N0) patients although; the available management policies include observation, elective neck dissection, or irradiation [71,99,169]. Even though there is no universal consensus guideline on the management of the neck in squamous cell carcinoma of oral cavity with clinical N0 necks, the predominant opinion is elective neck dissection [117,136]. Elective neck dissection refers to dissection of cervical lymphatics and fibrofatty tissues in the absence of an obvious clinical or radiological evidence of neck node metastasis for either staging or therapeutic purposes.…”

Section: Introductionmentioning

confidence: 99%