Surgical Treatment of Thymomas

Sawyers, John L.

doi:10.1001/archsurg.1968.01330230122017

Cited by 31 publications

(10 citation statements)

References 4 publications

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“…It is evident from our results and previous investigations that neither the clinical picture nor the radiographic findings can confirm whether a substernal tumour is benign or malignant (Key, 1954;Videbaek and Thomsen, 1959;Daniel, Diveley, Edwards, and Chamberlain, 1960;Kalter, Liebermann, and Pauzner, 1964;Sawyers and Foster, 1968;Shields, 1969;Fontanelle et al, 1971). Any patient with a tumour of the thymic region must therefore be subjected to operation without delay.…”

Section: Discussioncontrasting

confidence: 70%

“…The prognosis can be much more reliably evaluated on the basis of the tumour's gross extent (Wilkins, Edmunds, and Castleman, 1966;Oldham and Sabiston, 1967;Sawyers and Foster, 1968;Shields, 1969). Tumour penetration of the capsule worsens the prognosis considerably (Table IV).…”

Section: Discussionmentioning

confidence: 99%

“…Thymomas of uncertain histology should be treated postoperatively by high-voltage irradiation in maximum doses (Wilkins et al, 1966;Sawyers and Foster, 1968;Shields, 1969;Fontanelle et al, 1971).…”

Section: Discussionmentioning

confidence: 99%

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Tumours of the thymic region. Symptomatology, diagnosis, treatment, and prognosis.

Bertelsen¹,

Malmstrøm²,

Heerfordt³

et al. 1975

Thorax

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

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Tumours of the thymic region. Symptomatology, diagnosis, treatment, and prognosis.

Bertelsen¹,

Malmstrøm²,

Heerfordt³

et al. 1975

Thorax

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“…As there was some invasion of tumour cells into the capsule the tumour was considered potentially malignant and was therefore classified with malignant tumours according to Bergh, Rosengren, and Seeman (1968). The patient had no symptoms of myasthenia gravis, and there were no signs of Cushing's syndrome, nor was there any aplastic anaemia, sometimes reported as co-existing with thymoma (Sawyers and Foster, 1968). More than four years later she is well, and radiography of the chest shows no sign of a recurrence of the tumour.…”

Section: Resultsmentioning

confidence: 99%

Primary mediastinal tumours in Iceland 1956-70

Hallgrímsson

1972

Thorax

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Seventeen histologically proved cases of primary mediastinal tumours were diagnosed in Iceland in 1956-70, during which period the average population was 180,000. Sixteen of these cases, seen at the Department of Thoracic Surgery, Landspitalinn, Iceland, are analysed.The patients' ages ranged from 1 to 59 years; 6 were males and 10 were females. Their symptoms are described. The commonest histological types were cysts (312%) followed by lesions of lymphatic origin (25%); 62-5% of the tumours were benign and 37-5% malignant. The commonest sites were the anterior and posterior compartments where 62-6% of the tumours were located. Radical excision was performed in 11 cases, partial excision in one case, and biopsy of the mediastinal tumour in five cases. There were no postoperative deaths. Further details of each case are given and the fates of the patients have been traced.

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“…Sawyers et a1 [25] and LeGolvan et a1 [I81 found that invasion ocurred less frequently with the predominantly lymphocytic type of tumor and most often with the predominantly epithelial or mixed cell types. In this study 19% or predominantly lymphocytic thymomas were regarded as malignant (based on macroscopic invasion) while the corresponding figure was 56% for epithelial and mixed cell types of thymomas.…”

Section: Discussionmentioning

confidence: 99%

Treatment and prognosis of thymoma: A review of 25 cases

Appelqvist

Kostiainen

Franssila

et al. 1982

Journal of Surgical Oncology

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Experience of 25 patients with thymoma is reported. Based on the presence or absence of gross invasion 17 tumors were regarded as benign, 8 as malignant. All patients were operated on. Twenty-two had a complete excision, 2 a palliative excision, and 1 a biopsy only. Five patients received post-operative radiotherapy and 2 patients were given cytotoxic chemotherapy. None of the 17 patients with a benign thymoma had a recurrence or death due to thymoma during the follow-up. The five- and ten-year survival rates for malignant thymoma were 50% and 17%, respectively. Excision is the treatment of choice for all thymomas, since the prognosis for benign tumor is excellent and the malignancy can only by determined at exploration. Post-operative radiotherapy seems to be indicated in malignant thymoma. Myasthenia gravis and histologic features of thymoma have some value in predicting prognosis.

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Surgical Treatment of Thymomas

Cited by 31 publications

References 4 publications

Tumours of the thymic region. Symptomatology, diagnosis, treatment, and prognosis.

Tumours of the thymic region. Symptomatology, diagnosis, treatment, and prognosis.

Primary mediastinal tumours in Iceland 1956-70

Treatment and prognosis of thymoma: A review of 25 cases

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