Surgical treatment outcome of medically refractory huge giant papillary conjunctivitis

Yien, Lai; Sundar, Gangadhara; Ray, Manotosh

doi:10.1016/j.ajoc.2017.09.002

Cited by 5 publications

(2 citation statements)

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“…In a study removal of large papillae has been considered the best option for obstinate cases of GPC. Cryotherapy is also a better approach for the treatment and is also less invasive [30][31][32][33][34] .…”

Section: Giant Papillary Conjunctivitismentioning

confidence: 99%

Development in therapeutic strategies for allergic conjunctivitis

Singh,

Mazumder,

Monika

et al. 2023

Trends Immunother

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Conjunctivitis, also known as pink eye, is a conjunctival inflammation. It is brought on by bacteria, viruses, toxins, and allergies, including coronaviruses, the most frequent reason being allergic conjunctivitis (AC), which is brought on by exposure to pollutants like pollen, animal hair, or mold. The primary contributor to it is the linkage of immunoglobulin E caused by allergens and receptors on stimulated conjunctival mast cells. As a consequence, mast cells are degranulated, along with the release of histamine, cytokines, chemokines, and lipid mediators. The particular eye tissues impacted and the immune mechanism(s) (both local and systemic) that are involved all play a role in the clinical course, length, intensity, and co-morbidities. It frequently occurs in conjunction with allergic rhinitis, also known as allergic rhino-conjunctivitis and other allergy conditions. Atopic keratoconjunctivitis, giant papillary conjunctivitis, seasonal and perennial conjunctivitis, and vernal keratoconjunctivitis are the different types of allergic conjunctivitis. Ocular allergies are frequently misdiagnosed and undertreated, despite the emergence of innovative therapeutic strategies. This review focuses on several previously published studies to discuss the available therapeutic options for treating allergic conjunctivitis as well as the potential targets for the therapies. The association of conjunctivitis with COVID-19, along with recent patents and research, has also been explored.

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Section: Giant Papillary Conjunctivitismentioning

confidence: 99%

Development in therapeutic strategies for allergic conjunctivitis

Singh,

Mazumder,

Monika

et al. 2023

Trends Immunother

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“…In refractory cases to conservative or medical treatment, surgical treatment is essential. Surgical excision for giant conjunctival papillae together with AMT or autologous conjunctival graft to treat the tarsal conjunctival defect has been conducted with reasonable performance [11] .…”

Section: Introductionmentioning

confidence: 99%

The Outcome of Surgical Treatment of Giant Papillary Conjunctivitis by Simple Excision Only, Excision with Conjunctival Autograft or Amniotic Membrane Transplantation

Tawfik

2023

International Journal of Medical Arts

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Article informationBackground: Giant papillary conjunctivitis [GPC] is a type of inflammatory disease of the eye formed of "giant" papillae in the superior tarsal conjunctiva. Aim of the work:We have compared the effect of refractory giant papillary conjunctivitis management surgically with excision with and without conjunctival autograft or amniotic membrane transplantation. Patients and Methods: This was a randomized controlled trial conducted in the Ophthalmology Department, Al-Azhar University Hospitals, Egypt in the period from January 2022 to January 2023 included 45 patients presenting with giant papillary conjunctivitis who were treated surgically by one of the following techniques divided into 3 groups: group [1]; included 15 patients had undergone simple surgical excision of giant conjunctival papillae only, group [2]; included 15 patients had undergone surgical excision with conjunctival autograft and group [3]; included 15 patients had undergone surgical excision with amniotic membrane transplantation [AMT].Results: Results of this study reported that recurrence occurred higher in simple excision [10.7%] with a significant difference between groups [p value=0.021], also dry eye was higher in the same group [17.9%] with no significant difference. Conjunctival inflammation was higher in excision with AMT [10%] with no significant difference. Scar had been formed in one eye of simple excision patients only while vascularization was in one eye of excision with autologous conjunctival graft only. Conclusion:AMT or autologous conjunctival graft following excision of giant conjunctival papillae may reduce the chances of recurrence; also, surgical outcomes are better than that reported with the simple excision.

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