Surgically amenable epilepsies in children and adolescents: clinical, imaging, electrophysiological, and post-surgical outcome data

Terra, Vera Cristina; Fernandes, Regina Maria França; Inuzuka, Luciana Midori; Velasco, Tonicarlo Rodrigues; Alexandre, Veriano; Wichert‐Ana, Lauro; Funayama, Sandra Souza; Garzón, Eliana; Santos, Antônio Carlos dos; Araújo, David; Walz, Roger; Assirati, João Alberto; Machado, Hélio Rubens; Sakamoto, Américo Ceiki

doi:10.1007/s00381-004-1106-0

Cited by 45 publications

(35 citation statements)

References 18 publications

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“…There was no difference in number of seizure-free patients between those with symptomatic and cryptogenic/idiopathic etiologies. This finding confirms that brain imaging with good resolution performed in patients with intractable seizures may be able to disclose the etiology, which would lead to specific treatment for seizure control [24,28].…”

Section: Discussionsupporting

confidence: 78%

“…Early surgical treatment has been recommended if it is feasible, in consideration of the possible neuronal damage from prolonged and repeated seizures, risk of adverse effects of multiple antiepileptic drug regimens, risk from injury during seizure recurrence and neuropsychological comorbidities [22,23]. For those who had distinct etiologies of epilepsy such as brain tumor and vascular malformation, surgical treatment had been considered as the definitive method of treatment with high expectation of seizure control [24]. Children who had intractable complex partial seizures, which are typical presentations of seizures of temporal lobe origin along with suspected mesial temporal sclerosis, are good candidates for surgical treatment with favorable outcome.…”

Section: Discussionmentioning

confidence: 99%

“…This procedure is a complex procedure and requires human and financial resources along with technical skills and know-how, which might not be available in developing countries. In children who suffer from atonic seizures, which are commonly seen in those with Lennox-Gastaut syndrome and epileptic encephalopathies, corpus callosotomy is a palliative treatment and may be able to either decrease the frequency of seizures or withhold the seizures [24].…”

Section: Discussionmentioning

confidence: 99%

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Epilepsy Surgery in Children in Thailand: Preliminary Result from a Referral Center

Visudtibhan

Boongird

Khongkhatithum

et al. 2008

E&S

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, and The Ramathibodi Epilepsy Surgery Group Purpose:To demonstrate the preliminary result of the surgical treatment in a university-based hospital in Thailand Methods: The medical records of children and adolescents, who received surgical treatment for epilepsy at Ramathibodi Hospital, Bangkok, Thailand from October 2005 till July 2007 were reviewed. Results: 38 children and adolescents (21 males and 17 females; ages ranged from 14 months to 18 ½ years, mean 9.5 years, median 9.75 years) were included in this study. 18 and 20 were classified into symptomatic and cryptogenic/ idiopathic groups, respectively. LennoxGastaut syndrome, West syndrome, tuberous sclerosis and Sturge-Weber syndrome were diagnosed in 10, 3, 2 and 1 patients, respectively. Presurgical evaluation consisted of ictal/interictal video-monitored EEG recording, MRI of brain and ictal/interictal SPECT scans. Surgical treatment were lesionectomy, lobectomy, corpus callosotomy, corpus callosotomy with lobectomy, anterior

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Epilepsy Surgery in Children in Thailand: Preliminary Result from a Referral Center

Visudtibhan

Boongird

Khongkhatithum

et al. 2008

E&S

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“…In our study group the most common etiology was MCD as previously reported elsewhere (3,6,10,12). Other most common etiologies were tumors, HS and gliosis.…”

Section: Discussionsupporting

confidence: 68%

“…Other most common etiologies were tumors, HS and gliosis. MCD and tumors predominate under 12 years but in patients over 12 years HS is more commonly observed, likewise in other series (10). Five patients had both MCD and HS in pathological specimens which are classified as dual pathology.…”

Section: Discussionmentioning

confidence: 52%

Epilepsy surgery in children with lesional partial epilepsies

Erturk¹,

Özkara²,

Yalçınkaya³

et al. 2014

Turkish Neurosurgery

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AIm: Surgery for epilepsy is a significant treatment alternative with favorable outcomes in the pediatric age group. In this study we present the surgical outcomes of pediatric population referred to our center. mAterIAl and methOds:The clinical data of 126 patients (≤18 years) with lesional partial epilepsies operated in our center between 1995-2011 were evaluated retrospectively. Parameters investigated were gender, age at seizure onset, duration of epilepsy, etiology, type and location of operation and outcome. Seizure outcome was classified according to Engel's classification. results:The study group consisted of 70 males (55,6%) and 56 females (44.4%). The most common etiology was malformation of cortical development followed by tumors and hippocampal sclerosis. Overall 73.8% of patients had Engel I, 13.5% Engel II and 11.9% Engel III+IV postoperative seizure outcome. COnClusIOn:The results of our pediatric patients who underwent surgery were similar to previous reports in the literature. The seriousness of the clinical picture should tempt physicians to refer the patients as soon as possible to avoid long term complications like epileptic encephalopathies and the side effects of antiepileptic drugs during the development of the young brains.KeywOrds: Pediatric epilepsy, Epilepsy surgery, Seizure ÖZ AmAÇ: Pediatrik hastalarda epilepsi cerrahisi olumlu sonuçlarıyla önemli bir tedavi seçeneğini oluşturmaktadır. Çalışmada, merkezimizde epilepsi cerrahisi uygulanan pediatrik hastaların cerrahi sonuçlarını sunmayı amaçladık. yÖntem ve GereÇler: 1995-2011 yılları arasında merkezimizde lezyonel parsiyel epilepsi tanısıyla opere edilen 126 (yaş ≤18 yıl) hastanın klinik bilgileri retrospektif olarak gözden geçirildi. Değerlendirilen parametreler cinsiyet, nöbet başlangıç yaşı, epilepsi süresi, etiyoloji, ameliyat tipi ve lokalizasyonu ve sonlanımdan oluşuyordu. Nöbet sonlanımları Engel sınıflamasına göre sınıflandı.BulGulAr: Çalışma grubu 70 (%55,6) erkek ve 56 (%44,4) kızdan oluşmaktaydı. En sık etiyoloji kortikal gelişimsel malformasyonlar iken bunu tümörler ve hipokampal skleroz takip etmekteydi. Tüm hastaların %73.8'i Engel I, %13.5'i Engel II ve %11.9'u Engel III ve IV postoperatif cerrahi sonlanım göstermekteydi. sOnuÇ: Cerrahi uygulanan pediatrik hastalarımızın sonuçları literatürdeki çalışmalar ile benzerlik gösterdi. Klinik tablonun durumuna göre klinisyenlerin hastaları en kısa zamanda cerrahiye yönlendirmeleri epileptik ensefalopatiler gibi uzun dönem komplikasyonlardan ve ilaç yan etkilerinden kaçınmak için önem taşımaktadır.

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Surgery for epilepsy

West

Nolan

Cotton

et al. 2015

Cochrane Database of Systematic Reviews

150

110

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Surgically amenable epilepsies in children and adolescents: clinical, imaging, electrophysiological, and post-surgical outcome data

Abstract: Post-surgical seizure control in the pediatric population is similar to that in adult patients, despite the fact that epilepsies in this age group are more frequently of extratemporal origin, suggesting that surgery should be considered in children as soon as intractability is determined.

Cited by 45 publications

References 18 publications

Epilepsy Surgery in Children in Thailand: Preliminary Result from a Referral Center

Epilepsy Surgery in Children in Thailand: Preliminary Result from a Referral Center

Epilepsy surgery in children with lesional partial epilepsies

Surgery for epilepsy

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