Surreptitious Use of Salicylates: A Cause of Chronic Recurrent Gastroduodenal Ulcers

Perrault, Jean; Fleming, C. Richard; Dozois, Roger R.

doi:10.1016/s0025-6196(12)64854-x

Cited by 14 publications

References 25 publications

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Gastrocolic fistula as a complication of benign gastric ulcer: Report of four cases and update of the literature

Soybel

Kestenberg

Brunt

et al. 1989

Journal of British Surgery

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Four cases of gastrocolic fistula complicating benign gastric ulcer are described, bringing the total number of individually reviewed cases in the English language literature to 108. A review of 30 cases reported in the past 10 years reveals a surprisingly high percentage of young, female patients. Three-quarters of these patients used steroidal or nonsteroidal anti-inflammatory agents. The presence of such fistulae is suspected in patients complaining of weight loss, diarrhoea and faecal vomiting. Small fistulae may not be suspected when overshadowed by other complications of ulcer disease such as bleeding or perforated viscus. Medical management of benign gastrocolic fistulae may be indicated in some circumstances. Surgical treatment involves en bloc resection, including the fistula, and surrounding colon and gastric segments.

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Gastrocolic fistula as a complication of benign gastric ulcer: Report of four cases and update of the literature

Soybel

Kestenberg

Brunt

et al. 1989

Journal of British Surgery

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Hypothesis of Peptic Ulcer: A Modern Classification of a Multifactorial Disease

Caldwell¹,

McCallum²

1991

Pharmacology of Peptic Ulcer Disease

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Achlorhydria does not protect against benign upper gastrointestinal ulcers during NSAID use

et al. 1994

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It is widely accepted that the absence of acid-peptic activity excludes the presence of a benign upper gastrointestinal ulcer. We assessed the frequency of a history of benign upper gastrointestinal ulcer disease in patients with and without serological evidence of achlorhydria with reference to the use of nonsteroidal antiinflammatory drugs (NSAIDs). In total 857 patients were interviewed, using a standard questionnaire with emphasis on demographic data, chronic use of NSAID, and history of upper gastrointestinal ulcers. The frequency of achlorhydria was determined by extremely low serum levels of pepsinogen A (PgA < 17 micrograms/liter). Of the total group of patients, 36 patients (4.2%; 95% CI 2.9-5.5) had a PgA lower than 17 micrograms/liter. A history of benign upper gastrointestinal ulcer was found in 57/827 (6.9%) of patients with serum PgA higher than 17 micrograms/liter and in 3/36 (8.3%) of patients with serum PgA lower than 17 micrograms/liter (NS). The three patients with upper gastrointestinal ulcer and PgA lower than 17 micrograms/liter were known to have pernicious anemia (PA) before (two patients) or simultaneously (one patient) with the diagnosis of the upper gastrointestinal ulcer and were using NSAIDs at that time. The presence of gastric acid is not obligatory for the development of ulcers during NSAID use.

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Surreptitious Use of Salicylates: A Cause of Chronic Recurrent Gastroduodenal Ulcers

Cited by 14 publications

References 25 publications

Gastrocolic fistula as a complication of benign gastric ulcer: Report of four cases and update of the literature

Gastrocolic fistula as a complication of benign gastric ulcer: Report of four cases and update of the literature

Hypothesis of Peptic Ulcer: A Modern Classification of a Multifactorial Disease

Achlorhydria does not protect against benign upper gastrointestinal ulcers during NSAID use

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