20Objective: The objective of this study was to examine public attitudes towards third-party 21 reproduction and the disclosure of conception through third-party reproduction.
22Methods: We conducted the web-based survey for the public attitude towards third-party 23 reproduction in February 2014. Twenty-five hundred people were recruited with equal 24 segregation of age (20s, 30s, 40s, and 50s) and gender. We analyzed the association 25 between gender, age, infertility, and ethical view using a questionnaire regarding donor 26 sperm, donor oocyte, donor embryo, gestational surrogacy, and disclosure to offspring.
27Results: Of the respondents, 36.2% approved and 26.6% disapproved with gamete or 28 embryo donation. The frequency of those who approved was the lowest in females in the 29 50-59 years age group, and was significantly higher in males or females with infertility.
30Secondly, 40.9% approved and 21.8% disapproved with gestational surrogacy. The 31 frequency of those who approved gestational surrogacy was higher in males or females 32 with infertility. Thirdly, 46.3% of respondents agreed and 20.4% disagreed with 33 "offspring have the right to know their origin". Those who disagreed were primarily in 34 the 50-59 age group of both genders, and disagreement was significantly higher in the 35 infertility group compared with non-infertility group.
36Conclusion: In this study, public attitudes were affected by gender, age, and experience 3 37 of infertility. These study findings are important in understanding the attitude towards 38 third-party reproduction and disclosure to the offspring. Respondents having indecisive 39 attitudes were >30%, which might indicate an increased requirement for information and 40 education to enhance the discussion on the ethical consensus on third-party reproduction 41 in Japan. 42 43 44 45 46 47 48 49 50 51 52 53 54 4 55 Introduction 56 The treatment cycle of assisted reproductive technology (ART) has dramatically 57 increased; more than 1 million babies were born by ART between 2008 and 2010 [1]. In 58 Japan, 424151 treatment cycles were carried out in 2015, and 51001 neonates (1 in 19.7 59 neonates born in Japan) were born [2]. Although ART is now widely accepted as 60 clinically effective for treatment of many forms of subfertility, some people cannot 61 conceive due to poor reproductive function, for example, uterine infertility and poor 62 ovarian function. For those patients, ART using third party sperm, oocytes, or uterus is 63 an option, known as third-party reproduction.
64It is not technically difficult to perform third-party reproduction. Indeed, in the United
65States, there has been many cases of third-party reproduction, accounting for 16% of the 66 total ART [3]. However, ethical concerns have been raised about these fertility treatments.
67The attitudes toward third-party reproduction are different in each country, which also 68 depends on a country's law on whether oocyte donation is legal or not. For example, in 69 the EU, oocyte donation is permitted under c...