Surrogate Markers of Disease in Mastocytosis

Akin, Cem; Metcalfe, Dean D.

doi:10.1159/000048184

Cited by 44 publications

(31 citation statements)

References 21 publications

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“…Over one-half of children with mastocytosis are symptomatic, and the most common symptoms include flushing and pruritis, mostly related to mastocyte release of histamine, prostaglandin-D2 (PG-2), and leukotriene-C4 [1,4,[16][17][18][19]. Bronchospasm, a typical sequela of IgE-mediated reactions, it not a common mediator-related incident in mastocytosis [17,20,21].…”

Section: Clinical Coursementioning

confidence: 99%

“…Mast cell markers include surface tyrosine kinase receptors, for example CD34, CD13, CD117 (''C-KIT'', seen in those with and without mastocytosis), and CD25 (a marker for abnormal mast cells) [18,28,30]. Under the predominant theory of the adult form of the disease, an ''activating'' point mutation at the C-KIT locus (Asp816Val, or codon 816) codes for an abnormal cell membrane receptor protein for SCF, producing clonal mast cell lines that lack normal growth and differentiation [31][32][33].…”

Section: Pathogenesismentioning

confidence: 99%

“…Patients with mastocytosis experience both immune (IgE-related) and non-immune anaphylaxis, and the overall incidence of anaphylaxis in patients with mastocytosis has been reported to be higher than in the general population [1,16,35,51]. Unlike patients who do not have mastocytosis, however, the serum tryptase level in mastocytosis patients experiencing anaphylaxis does not fall within the normal range at several hours but can remain persistently elevated [18]. In some cases this laboratory finding may lead to the initial diagnosis of mastocytosis.…”

Section: Preoperative Preparationmentioning

confidence: 99%

“…Epinephrine should be on hand for all mastocytosis patients in the perioperative period; in addition to giving cardiovascular support, epinephrine may hinder mast cell degranulation via b 2 -adrenergic receptor stimulation [41]. Avoidance of b-adrenergic antagonists has been recommended on the theory that b-blockade counteracts epinephrine resuscitation effects [18,86]. The need for aggressive treatment of other intraoperative signs of mediator release, for example flushing, is less clear.…”

Section: Intraoperative Crisis Managementmentioning

confidence: 99%

“…During the early phase of immune-mediated anaphylaxis, both serum histamine and tryptase levels increase. The serum half-life of histamine is less than 30 min and levels fall abruptly within 1 h of anaphylaxis [18,49,66]. In both IgE-like and nonimmune anaphylaxis-like incidents, tryptase, with a longer serum half life of approximately 90 min, peaks as histamine levels are declining and will not typically fall to normal levels for 4-6 h after the incident [91].…”

Section: Intraoperative Crisis Managementmentioning

confidence: 99%

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Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Mastocytosis is an orphan disease rarely encountered by practicing anesthesiologists. Children with mastocytosis often present for procedures or surgery requiring anesthesia. Because many of the medications commonly used in pediatric anesthesia have been reported to initiate mast cell activation, parents are often very anxious about their child's perioperative experience. Laboratory investigations of serum histamine assays associated with different anesthetic drugs have not been shown to predict mast cell degranulation in these patients. However, the pediatric literature suggests that children with disease limited to the skin rarely suffer serious side effects from anesthesia, and there are no reported fatalities. Preoperative prophylaxis is usually based on expert opinion and case reports. Detailed tables summarizing reports of anesthetic medications used for children with mastocytosis undergoing anesthesia, reported side effects, and suggested prophylaxis regimens are included in this review.

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Section: Clinical Coursementioning

confidence: 99%

Section: Pathogenesismentioning

confidence: 99%

Section: Preoperative Preparationmentioning

confidence: 99%

Section: Intraoperative Crisis Managementmentioning

confidence: 99%

Section: Intraoperative Crisis Managementmentioning

confidence: 99%

See 3 more Smart Citations

Anesthetic considerations in pediatric mastocytosis: a review

Klein

Misseldine

2013

J Anesth

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Isocratic Separation of Dansylated Biogenic Amines on a C₈‐Bonded Silica Column under the LC Elution of Methanol‐Based Mobile Phase

Yeh

Chen

2011

J Chinese Chemical Soc

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Under the elution of methanol-based mobile phase, the isocratic resolution of 12 biogenic amines, including 1 aromatic, 2 heterocyclic and 9 aliphatic amines, as the dansylated derivatives has been accomplished in less than 25 minutes on a 15 cm C 8 -bonded column. The resolution can not be reproduced on other examined alkyl-bonded phases (e.g., C 4 and C 18 ) under the same chromatographic conditions, or in the reversed-phase mode. The retention, mainly as a result of hydrophobic interaction between analyte and stationary phase, can be adjusted by varying the percentage of methanol in the mobile phase. Also, incorporating acetic acid as additive to the mobile phase to protonate the analyte and silanol groups that are little shielding on the surface of silica gel reduces the dipole-dipole interaction, and thus the retention scale, which in turn deteriorates the resolution. Furthermore, the elution reversal is plausible for some of analytes as a greater percent of acetic acid is used in the elution. Values of correlation coefficients (R 2 ) range between 0.9995 and 0.9996, indicating good linearity.

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Assay of histamine by nano‐liquid chromatography/tandem mass spectrometry with a packed nanoelectrospray emitter

Song

Quan

Liu

2004

Rapid Comm Mass Spectrometry

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A nano-liquid chromatographic /tandem mass spectrometric (nanoHPLC/MS/MS) method has been developed for the sensitive determination of histamine, a vital neurotransmitter. The method involved pre-column derivatization of histamine with 7-fluoro-4-nitrobenzoxadiazole (NBD-F), thus increasing the hydrophobicity of the analyte and allowing it to be retained and stacked on a nanoelectrospay emitter packed with C18 reversed-phase particles. Sodium 1-heptanesulfonate, added as an ion-pairing reagent in the mobile phase for sample loading, was found to facilitate greatly the analyte retention. The packed nanoelectrospray emitter was easily prepared using fused-silica capillary of 75 microm i.d., and included creating an electrospray emitter tip and then slurry-packing a 5 cm long column with 5 microm silica-based particles. After sample loading, the mobile phase was changed for separation and a characteristic precursor-to-product ion transition, m/z 275 --> 258, was used for the quantification. A linear calibration curve in the range from 1.0-100 ng/mL histamine with an r2 value of 0.9995 was obtained. The detection limit was estimated to be 0.1 ng/mL histamine in water. In a preliminary validation, the method was applied to determine histamine in alcoholic beverages and rat brain tissues.

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Surrogate Markers of Disease in Mastocytosis

Cited by 44 publications

References 21 publications

Anesthetic considerations in pediatric mastocytosis: a review

Anesthetic considerations in pediatric mastocytosis: a review

Isocratic Separation of Dansylated Biogenic Amines on a C₈‐Bonded Silica Column under the LC Elution of Methanol‐Based Mobile Phase

Assay of histamine by nano‐liquid chromatography/tandem mass spectrometry with a packed nanoelectrospray emitter

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Surrogate Markers of Disease in Mastocytosis

Cited by 44 publications

References 21 publications

Anesthetic considerations in pediatric mastocytosis: a review

Anesthetic considerations in pediatric mastocytosis: a review

Isocratic Separation of Dansylated Biogenic Amines on a C8‐Bonded Silica Column under the LC Elution of Methanol‐Based Mobile Phase

Assay of histamine by nano‐liquid chromatography/tandem mass spectrometry with a packed nanoelectrospray emitter

Contact Info

Product

Resources

About

Isocratic Separation of Dansylated Biogenic Amines on a C₈‐Bonded Silica Column under the LC Elution of Methanol‐Based Mobile Phase