Surveillance and trends of antimicrobial resistance among clinical isolates of anaerobes in Kuwait hospitals from 2002 to 2007

Jamal, Wafaa; Shahin, Mojtaba; Rotimi, V.O.

doi:10.1016/j.anaerobe.2009.04.004

Cited by 29 publications

(26 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These resistance levels exceed those reported previously for clinical isolates from a range of body sites. 11,14,15 Increased macrolide resistance amongst CF Prevotella isolates is similar to that previously reported for the CF-associated Streptococcus milleri group by Grinwis et al, 16 who linked increased macrolide resistance with chronic exposure to azithromycin. We also found that current prescription of azithromycin was associated with significantly higher azithromycin MICs, corroborating the results of recent clinical trials in CF, non-CF bronchiectasis and COPD, 9,17,18 which reported an association between chronic macrolide exposure and increased resistance amongst respiratory pathogens and members of the airway microbiota.…”

Section: Discussionsupporting

confidence: 73%

“…Meropenem, piperacillin/tazobactam and chloramphenicol all demonstrated excellent in vitro activity, with all isolates tested being susceptible. Previous studies have also reported all Prevotella isolates as susceptible to piperacillin/ tazobactam, 11,12 whilst meropenem resistance is rare 11 and chloramphenicol resistance amongst Prevotella has yet to be detected. 13 Furthermore, metronidazole resistance was only detected in a small number of isolates.…”

Section: Discussionmentioning

confidence: 99%

“…Co-amoxiclav resistance (21%) was highest in the UK CF isolate group and exceeded the levels reported by others. 11,14,15 When the three UK groups were compared, CF isolates demonstrated significantly higher MICs of both azithromycin and clindamycin than observed for invasive and healthy control isolates. These resistance levels exceed those reported previously for clinical isolates from a range of body sites.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis

Sherrard

Graham

McGrath

et al. 2013

Journal of Antimicrobial Chemotherapy

View full text Add to dashboard Cite

Objectives: To compare the antimicrobial susceptibility of Prevotella spp. isolated from cystic fibrosis (CF) and non-CF patients and analyse the impact of antibiotic prescribing in the preceding year on resistance amongst CF isolates. Methods:The susceptibility of 80 CF Prevotella isolates to 12 antibiotics was compared with that of 50 Prevotella isolates from invasive infections in people who did not have CF and 27 Prevotella isolates from healthy controls.Results: All isolates were susceptible to chloramphenicol, meropenem and piperacillin/tazobactam, with only four isolates resistant to metronidazole. However, resistance to amoxicillin, ceftazidime and tetracycline was apparent in all groups. Significant differences in clindamycin resistance (UK CF, 56%; UK invasive, 10%) and co-amoxiclav non-susceptibility (UK CF, 32%; UK invasive, 12%) were observed between UK CF and UK invasive isolates. The likelihood of non-susceptibility to clindamycin and co-amoxiclav in UK CF isolates was 5.5-fold and 2.5-fold higher relative to that in UK invasive isolates, respectively. Azithromycin MICs were also significantly higher for CF isolates (P,0.001), which was associated with current prescription of azithromycin. More than 50% of clinical isolates tested in this study were b-lactamase positive.Conclusions: This study profiles antibiotic susceptibility in Prevotella spp. in CF and demonstrates that meropenem, piperacillin/tazobactam, chloramphenicol and metronidazole are likely to be the most effective antibiotics if treatment is indicated.

show abstract

Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antibiotic resistance in Prevotella species isolated from patients with cystic fibrosis

Sherrard

Graham

McGrath

et al. 2013

Journal of Antimicrobial Chemotherapy

View full text Add to dashboard Cite

show abstract

“…60% [1]. The antimicrobial susceptibility patterns of anaerobes have become less predictable owing to increasing resistance [2,3,5]. The emergence of highly virulent or multidrug-resistant strains is challenging current therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Anaerobic infections are more frequent in immunocompromised patients and the elderly. The increasing resistance to antimicrobial agents among anaerobic pathogens has been a global problem [1][2][3]. Treatment of anaerobic infections is also complicated by slow growth of these pathogens.…”

Section: Introductionmentioning

confidence: 99%