Surveillance Following Treatment of Esophageal Cancer

Bakhos, Charles; Acevedo, Edwin; Petrov, Roman; Abbas, Abbas E.

doi:10.1016/j.suc.2021.03.011

Cited by 6 publications

(5 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is often combined with neoadjuvant or perioperative chemotherapy with or without radiotherapy. 1 Trimodality therapy with neoadjuvant chemoradiation followed by surgery has become the standard of care for many patients. 2 Surgical treatment of esophageal cancer can be done through an open transhiatal, transthoracic (2-stage or Ivor-Lewis) or 3-stage (McKeon) procedure.…”

mentioning

confidence: 99%

“…14 The other regimen used includes surveillance imaging with different techniques and invasive diagnostic procedures such as contrast computed tomography (CT) of chest and abdomen, positron emission tomography (PET) scan, magnetic resonance imaging (MRI), and endoscopy and/or endoscopic ultrasonogrophy. 1 The efficacy of each surveillance modality has not been systematically assessed in large-cohort studies.…”

mentioning

confidence: 99%

“…10 Despite significant progress in the diagnosis and staging of esophageal cancer after esophagectomy, there is no single modality that can reliably detect local recurrence or residual disease with clinical acceptable degree of accuracy, therefore multiple imaging methods need to be used to detect recurrences. 1,17 It is possible that a prospective, randomized study of subjects after esophagectomy in order to monitor surveillance could include three groups of patients: 1) an HPE group; 2) a SI group, and 3) a combined HPE plus SI group, along with the timing, intervals, and duration of this surveillance in order to determine the best surveillance regimen and the survival in this challenging disease after surgery. In addition, including multiple cancer centers would be ideal.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Optimal Surveillance Regimen to Identify Cancer Recurrence after Esophagectomy: Surveillance Imaging or History and Physical Examination? An Anesthesiologist's Point of View

Campos

2022

Journal of Cardiothoracic and Vascular Anesthesia

View full text Add to dashboard Cite

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Optimal Surveillance Regimen to Identify Cancer Recurrence after Esophagectomy: Surveillance Imaging or History and Physical Examination? An Anesthesiologist's Point of View

Campos

2022

Journal of Cardiothoracic and Vascular Anesthesia

View full text Add to dashboard Cite

“…Therefore, to improve the outcomes of esophageal cancer, it is necessary to not only improve the patient’s awareness of the importance of timely treatment but to also identify the appropriate investigations to support an early diagnosis. This will enable patients to receive effective early intervention to delay the progression of disease, improving the prognosis of patients with esophageal cancer ( 8 , 9 ).…”

Section: Discussionmentioning

confidence: 99%

The diagnostic significance of 64-slice spiral CT combined with serological CA19-9, Bcl-2, CYFRA21-1 detection in thoracic esophageal carcinoma

Hao¹,

Liu²,

Zhao³

et al. 2021

Transl Cancer Res TCR

View full text Add to dashboard Cite

Background To analyze the clinical value of multi-slice spiral computed tomography (MSCT) combined with carbohydrate antigen 19-9 (CA19-9), B-cell leukemia/lymphoma-2 protein (Bcl-2), and cytokeratin 19 fragment antigen 21-1 (CYFRA21-1) detection in the diagnosis of thoracic esophageal cancer. Methods The clinical data of 74 patients with thoracic esophageal cancer admitted to the Dazu District People’s Hospital in Chonqing, China, from December 2019 to December 2020 were collected (esophageal cancer group), and their computed tomography (CT) signs were analyzed. Another 55 healthy people who underwent physical examination during the same period in the hospital were selected for the healthy group. The serum levels of CA19-9, Bcl-2, and CYFRA21-1 in the different populations were compared, using the receiver operating characteristic (ROC) curve to analyze the value of MSCT combined with CA19-9, Bcl-2, and CYFRA21-1 detection in the diagnosis of thoracic esophageal cancer. Results The serum levels of CA19-9, Bcl-2, and CYFRA21-1 in patients of the esophageal cancer group were significantly higher than those in the healthy group (P<0.05). The serum levels of CA19-9, Bcl-2, and CYFRA21-1 in patients with poorly differentiated, stage III–IV carcinoma and lymph node metastasis were significantly higher than in those patients with moderately well-differentiated, stage I–II carcinoma and no lymph node metastasis (P<0.05). The CT scans of patients in the esophageal cancer group showed esophageal walls with irregular, needle-shaped, circular, or localized eccentric thickening and narrowed lumens, which were dilated above the cancerous lesions. Some tumors compressed adjacent organs to deform and shift the organs, resulting in the disappearance of surrounding fat layers. Enhanced scans showed mild or moderate enhancement, with large-diameter lesions unable to enhance central, low-density, necrotic areas. The ROC curve showed that the area under the curve (AUC) and the sensitivity and specificity of MSCT combined with CA19-9, Bcl-2, and CYFRA21-1 detection were all higher than for esophageal lesions detected by individual indicators. Conclusions CA19-9, Bcl-2, and CYFRA21-1, which are abnormally expressed in patients with esophageal cancer, may be related to the occurrence and development of esophageal cancer. MSCT combined with CA19-9, Bcl-2, and CYFRA21-1 detection appears to enhance the diagnosis of esophageal cancer.

show abstract

“…According to the pathological types, ESCA can be divided into esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC). The conventional treatment of ESCA mainly includes radiotherapy, chemotherapy, surgical resection, immunotherapy, and neoadjuvant therapy [3][4][5][6][7] . Recent developments in treatment and diagnostic techniques have not signi cantly improved the prognosis of ESCA, and the 5-year survival rate of ESCA patients still varies between 10% and 30% 1 .…”

Section: Introductionmentioning

confidence: 99%

High expression of ELAVL1 predicts poor prognosis of Esophageal Carcinoma

Gao

et al. 2022

Preprint

View full text Add to dashboard Cite

N6-methyladenosine (m6A) is the most prevalent RNA epigenetic regulation in eukaryotic cells. However, understanding of m6A in Esophageal carcinoma (ESCA) is very limited. We designed this study to investigate the role of m6A in ESCA. Expression pattern of m6A regulatory genes were extracted from gene array of 21cases of ESCA and public datasets to investigate the clinical relevance of m6A regulatory genes in ESCA. Next, we used public datasets to evaluate the relationship between m6A regulatory genes change and survival rates by the Kaplan-Meier analysis method. KEGG Pathway Enrichment Analysis and Gene Set Enrichment Analysis to identify the signaling pathways. The differences of immune cell subtypes were evaluated based on CIBERSORT algorithm. High expression level of ELAVL1 was significantly associated with worse overall survival (OS) of ESCA (P < 0.05). The levels of ELAVL1 were positively associated with macrophages M0(R=0.34, P=0.025), T follicular helper cells (R=0.44, P=0.0035), while Plasma cells (R=0.59, P=0.000041), and CD8 T cells (R=0.44, P=0.0038) exhibited an opposite result. ELAVL was in positive association with PSMC3IP. Our findings highlight the function and prognostic value of ELAVL1 in ESCA and extend the understanding of the importance of RNA epigenetics in cancer biology.

show abstract

Surveillance Following Treatment of Esophageal Cancer

Cited by 6 publications

References 45 publications

Optimal Surveillance Regimen to Identify Cancer Recurrence after Esophagectomy: Surveillance Imaging or History and Physical Examination? An Anesthesiologist's Point of View

Optimal Surveillance Regimen to Identify Cancer Recurrence after Esophagectomy: Surveillance Imaging or History and Physical Examination? An Anesthesiologist's Point of View

The diagnostic significance of 64-slice spiral CT combined with serological CA19-9, Bcl-2, CYFRA21-1 detection in thoracic esophageal carcinoma

High expression of ELAVL1 predicts poor prognosis of Esophageal Carcinoma

Contact Info

Product

Resources

About