Surveillance for colonic carcinoma in ulcerative colitis

Rosenstock, Eric; Farmer, Richard G.; Petras, Robert E.; Sivak, Michael; Rankin, George B.; Sullivan, B.H.

doi:10.1016/0016-5085(85)90653-5

Cited by 251 publications

(87 citation statements)

References 16 publications

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“…Within single patients, we frequently observed aneuploid cell populations from separate mucosa samples with similar DNA indices, (Table II, Figure 2) as has also been reported by others , Rutegard et al, 1989. We also found the same DNA index in cells from mucosa-and carcinoma samples within single patients.…”

Section: Discussionsupporting

confidence: 90%

“…Several reports have shown a close association between dysplastic changes in tumour-distant flat mucosa and coexisting colorectal carcinoma in patients with total ulcerative colitis (Morson & Pang, 1967;Riddell & Morson, 1979;Rosenstock et al, 1985, Ransohoff et al, 1985. However, dysplasia alone seems to be an insufficient marker for the optimal identification of patients at increased cancer risk.…”

mentioning

confidence: 99%

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Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Meling

Clausen²,

Bergan³

et al. 1991

Br J Cancer

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Meling

Clausen²,

Bergan³

et al. 1991

Br J Cancer

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“…When colon cancer is identifi ed, the need for surgery is obvious; similarly, the colonoscopic biopsy diagnosis of dysplasia in fl at mucosa is oft en indicative of a concurrent or future cancer. Such fi ndings are an absolute indication for colectomy in patients with HGD ( 413,414 ), and should prompt consideration of colectomy in patients with LGD as well. LGD in a mass lesion ( 415 ) that does not resemble a typical sporadic adenoma and cannot be resected endoscopically (see below), or a stricture that is symptomatic or not passable during colonoscopy ( 393,395,396 ), especially in long-standing disease, is oft en indicative of coexistent colon cancer; hence, colectomy is advisable.…”

Section: Recommendations For Cancer Surveillancementioning

confidence: 99%

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Kornbluth

Sachar

2010

American Journal of Gastroenterology

1,156

977

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Guidelines for clinical practice are aimed to indicate preferred approaches to medical problems as established by scientifi cally valid research. Double-blind placebo controlled studies are preferable, but compassionate-use reports and expert review articles are used in a thorough review of the literature conducted through Medline with the National Library of Medicine. When only data that will not withstand objective scrutiny are available, a recommendation is identifi ed as a consensus of experts. Guidelines are applicable to all physicians who address the subject regardless of specialty training or interests and are aimed to indicate the preferable but not necessarily the only acceptable approach to a specifi c problem. Guidelines are intended to be fl exible and must be distinguished from standards of care, which are infl exible and rarely violated. Given the wide range of specifi cs in any healthcare problem, the physician must always choose the course best suited to the individual patient and the variables in existence at the moment of decision. Guidelines are developed under the auspices of the American College of Gastroenterology and its Practice Parameters Committee and approved by the board of trustees. Each has been intensely reviewed and revised by the Committee, other experts in the fi eld, physicians who will use them, and specialists in the science of decision analysis. The recommendations of each guideline are therefore considered valid at the time of composition based on the data available. New developments in medical research and practice pertinent to each guideline will be reviewed at a time established and indicated at publication to assure continued validity. The recommendations made are based on the level of evidence found. Grade A recommendations imply that there is consistent level 1 evidence (randomized controlled trials), grade B indicates that the evidence would be level 2 or 3, which are cohort studies or case -control studies. Grade C recommendations are based on level 4 studies, meaning case series or poor-quality cohort studies, and grade D recommendations are based on level 5 evidence, meaning expert opinion.

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“…suggested that dysplasia associated with a DALM, especially a polypoid mass was an indication for colectomy in view of the increased likelihood of cancer 2 . Several subsequent studies seem to support this argument [4][5][6] . The criticism leveled at these studies was that the lesions detected were fairly advanced, and despite endoscopic biopsies not revealing a cancer, subsequent surgery and histological examination of the specimens revealed the underlying cancer.…”

Section: Introductionmentioning

confidence: 93%

Patients with Endoscopically Visible Polypoid Adenomatous Lesions Within the Extent of Ulcerative Colitis Have an Increased Risk of Colorectal Cancer Despite Endoscopic Resection

et al. 2016

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Objectives: Ulcerative colitis (UC) is associated with an increased risk of colorectal cancer (CRC). Few studies have looked at long term outcomes of endoscopically visible adenomatous lesions removed by endoscopic resection in these patients. We aimed to assess the risk of developing CRC in UC patients with adenomatous lesions that develop within the segment of colitis compared to the remainder of an ulcerative colitis cohort. Conclusions: The risk of developing CRC is significantly higher in UC patients with polypoid adenomatous lesions, within the extent of inflammation, despite endoscopic resection. Patients and physicians should take the increased risk into consideration during follow up of these patients.

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Surveillance for colonic carcinoma in ulcerative colitis

Cited by 251 publications

References 16 publications

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Flow cytometric DNA ploidy pattern in dysplastic mucosa, and in primary and metastatic carcinomas in patients with longstanding ulcerative colitis

Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee

Patients with Endoscopically Visible Polypoid Adenomatous Lesions Within the Extent of Ulcerative Colitis Have an Increased Risk of Colorectal Cancer Despite Endoscopic Resection

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