Surveillance for Influenza Admissions Among Children Hospitalized in Canadian Immunization Monitoring Program Active Centers, 2003–2004

Moore, Dorothy; Vaudry, Wendy; Scheifele, David W.; Halperin, Scott A.; Déry, Pierre; Ford-Jones, E. Lee; Arishi, Haider M.; Law, Barbara; LeBel, Marc; Saux, Nicole Le; Grimsrud, Karen; Tam, Theresa

doi:10.1542/peds.2005-2744

Cited by 82 publications

(59 citation statements)

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“…Elevated CK levels in 12% of patients affected by influenza but without cardiac symptoms and in up to 15% of patients with abnormal ECG patterns suggestive of myocarditis have been reported previously (4, 7). Myocardial damage or clinical myocarditis has also been reported in studies from Japan (6) and Canada (9). In molecular studies conducted in the United States and in Italy, influenza virus accounted for 2 to 10% of all viral agents isolated from myocardial tissues (1, 3).…”

Section: Case Reportmentioning

confidence: 95%

Cardiac Tamponade and Heart Failure Due to Myopericarditis as a Presentation of Infection with the Pandemic H1N1 2009 Influenza A Virus

et al. 2010

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We describe a fatal case of myopericarditis presenting with cardiac tamponade in a previously healthy 11-year-old child. Pandemic H1N1 2009 influenza A virus sequences were identified in throat and myocardial tissues and pericardial fluid, suggesting damage of myocardial cells directly caused by the virus. CASE REPORTHere, we report a fatal case of myopericarditis presenting with cardiac tamponade associated with infection with the pandemic A/H1N1 2009 influenza virus in a previously healthy 11-year-old girl with no known risk factors, including obesity, for severe, complicated pandemic influenza.The patient developed a high fever (39.2°C) with coughing and vomiting on the evening of 28 October. The next morning, she was visited by a general practitioner, who prescribed antipyretic, antibiotic, and cortisone treatments. About 36 h after the onset of symptoms, the girl presented to the emergency unit of the district hospital with asthenia and dizziness. She was pale and afebrile at 35°C, with tachycardia of 140 beats/min and tachypnea of 32 breaths/min. Routine blood samples were analyzed. The white blood cell count was elevated at 23.8 ϫ 10 9 cells/liter, and C-reactive protein was elevated at 21.6 mg/liter. Her creatine kinase (CK) level was elevated at 5,814 IU/liter (normal range, 26 to 140 IU/liter), the troponin level was 4.24 ng/ml (normal range, 0 to 0.060 ng/ml), the myoglobin level was 1,849.4 ng/ml (normal range, 12 to 76 ng/ml), and the lactate dehydrogenase level was 1,408 IU/liter (normal range, 266 to 500 IU/liter). Her chest X-ray was reported to be clear. An electrocardiogram (ECG) showed sinus tachycardia with diffuse ST segment elevation. An urgent echocardiogram was performed, which demonstrated normal ventricle size, severely compromised pump function (ejection fraction, 20 to 30%), diffuse ipokinesia, and a small pericardial effusion, consistent with myopericarditis with a predominant myocarditic component. Metabolic lactic acidosis was also detected and treated with intravenous administration of Na ϩ -HCO 3 . Because of the need for specialized care and treatment, the patient was transferred to a regional pediatric hospital, but during ambulance transport she had loss of consciousness and needed respiratory assistance. Clinical conditions worsened during transfer to the pediatric intensive care unit (ICU): a peripheral pulse was absent, the central pulse was weak, and the capillary refill time was Ͼ5 s. Cardiac frequency (CF) detected by the monitor was 110 beats/min with a wide QRS interval. CF rapidly decreased. Atropine was administered, and cardiopulmonary resuscitation (CPR) maneuvers were performed. The central pulse became absent, and the echocardiogram showed no contractile activity.The pathological exam showed macroscopic changes such as increased ventricular size (left ventricle thickness, 2.2 cm; right ventricle thickness, 0.35 cm); the left/right ventricle size ratio was 6.28, versus a normal value of 3.1. Pericardial effusion (150 ml) was detected. Pulmonary congestion leading ...

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Section: Case Reportmentioning

confidence: 95%

Cardiac Tamponade and Heart Failure Due to Myopericarditis as a Presentation of Infection with the Pandemic H1N1 2009 Influenza A Virus

et al. 2010

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“…[1][2][3][4][5] Nationally, only 56.6% of children 6 months to 17 years receive at least 1 needed dose in a given influenza season. 6 Young children ,9 years old are at particular risk for undervaccination because, depending on previous influenza vaccination status, they may need to receive 2 doses in a given season.…”

Section: What This Study Addsmentioning

confidence: 99%

Text Message Reminders for Second Dose of Influenza Vaccine: A Randomized Controlled Trial

et al. 2015

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To determine whether provision of vaccine-health-literacy-promoting information in text message vaccine reminders improves receipt and timeliness of the second dose of influenza vaccine within a season for children in need of 2 doses.METHODS: During the 2012-2013 season, families of eligible 6-month through 8-year-old children were recruited at the time of their first influenza vaccination from 3 community clinics in New York City. Children (n = 660) were randomly assigned to "educational" text message, "conventional" text message, and "written reminder-only" arms. At enrollment, all arms received a written reminder with next dose due date. Conventional messages included second dose due date and clinic walk-in hours. Educational messages added information regarding the need for a timely second dose. Receipt of second dose by April 30 was assessed by using x 2 tests. Timeliness was assessed by receipt of second dose by 2 weeks after due date (day 42) using x 2 and over time using a Kaplan-Meier analysis.RESULTS: Most families were Latino and publicly insured with no significant between-arm differences between groups. Children in the educational arm were more likely to receive a second dose by April 30 (72.7%) versus conventional (66.7%) versus written reminder-only arm (57.1%; P = .003). They also had more timely receipt by day 42 (P , .001) and over time (P , .001).CONCLUSIONS: In this low-income, urban, minority population, embedding health literacy information improved the effectiveness of text message reminders in promoting timely delivery of a second dose of influenza vaccine, compared with conventional text messages and written reminder only. WHAT'S KNOWN ON THIS SUBJECT:Influenza vaccine coverage is low, and young children in need of 2 doses in a given season are at particular risk, with less than half receiving both doses. Text message vaccine reminders increase receipt of first dose of influenza vaccine. WHAT THIS STUDY ADDS:Little is known about what types of text message reminders are most effective, including embedding educational information. We demonstrate that text message reminders increase timely receipt of the second dose of influenza vaccine and embedding health literacy information improves effectiveness.

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“…Comprehensive data on intensive care admissions are not available on the HES database [19]. Hence the risk of a pregnant woman already hospitalised for influenza being admitted to intensive care was estimated from two sources: (i) the placebo arms of published trials of influenza-related interventions [20][21][22][23] [24], an anonymised database with information from approximately 70 sentinel practices in England and Wales. These included consultations with a READ code for pleurisy, pneumonia, bronchitis, laryngitis and influenza-like illness (ILI).…”

mentioning

confidence: 99%

The cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales

Jit¹,

Cromer²,

Baguelin³

et al. 2010

Vaccine

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We assessed the cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales, taking into account the timing of vaccination relative to both the influenza season and trimester of pregnancy. Women were assumed to be vaccinated in their second or third trimester. Vaccination between September and December was found to have an incremental cost-effectiveness ratio of £23,000 per QALY (95% CI £10,000 -£140,000) if it is assumed that infants are partially protected through their mothers, and of £29,000 per QALY gained (95% CI £14,000 -£200,000) if infants are not protected. If some vaccine protection lasts for a second season, then the ratio is only £15,000 per QALY gained (95% CI £6,000 -£91,000). Most of the benefit of vaccination is in preventing symptomatic episodes, regardless of health care resource use. Extending vaccination beyond December is unlikely to be cost-effective unless there is good protection into a second influenza season. Key sources of uncertainty are the cost of vaccine delivery and the quality of life detriment due to a clinically apparent episode of confirmed influenza. The cost of vaccine purchase itself is relatively low.3

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Surveillance for Influenza Admissions Among Children Hospitalized in Canadian Immunization Monitoring Program Active Centers, 2003–2004

Abstract: Healthy young children and children with chronic conditions are at risk for serious illness with influenza. Ongoing surveillance is needed to evaluate the impact of changing immunization recommendations on the burden of influenza illness in children.

Cited by 82 publications

References 32 publications

Cardiac Tamponade and Heart Failure Due to Myopericarditis as a Presentation of Infection with the Pandemic H1N1 2009 Influenza A Virus

Cardiac Tamponade and Heart Failure Due to Myopericarditis as a Presentation of Infection with the Pandemic H1N1 2009 Influenza A Virus

Text Message Reminders for Second Dose of Influenza Vaccine: A Randomized Controlled Trial

The cost-effectiveness of vaccinating pregnant women against seasonal influenza in England and Wales

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