Surveillance for Invasive Meningococcal Disease in Children, US–Mexico Border, 2005–20081

Chacón-Cruz, Enrique; Sugerman, David; Ginsberg, Michele; Hopkins, Jackie; Hurtado-Montalvo, J.A.; Lopez-Viera, J.L.; Lara-Muñoz, Cesar Arturo; Rivas-Landeros, Rosa Maria; Volker, Maria Luisa; Leake, John A. D.

doi:10.3201/eid1703.101254

Cited by 21 publications

(36 citation statements)

References 9 publications

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“…Accordingly, we have already published a 3 years binational study comparing MD incidence on the Tijuana, Mexico and San Diego, California border (the highest transited frontier in the world). Our publication revealed that in Tijuana, MD was not lower than in San Diego [4]. This was the first study that actually showed that MD is significantly present in Mexican territory.…”

Section: Introductionmentioning

confidence: 53%

“…Only one patient had the tetravalent (A, C, Y, W) meningococcal conjugate vaccine, but this child developed a serogroup B related MD. Median days of illness prior to admission was of two (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14). At admission, 47 (92.15%) had meningitis, 24 (47%) purpura, 4 (7.84%) conjunctivitis and 2 (3.92%) pleural effusion (both patients with pleural effusion had a serogroup Y related MD).…”

Section: Resultsmentioning

confidence: 99%

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Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Chacón-Cruz¹,

Alvelais-Palacios²,

Lopatynsky-Reyes³

et al. 2017

J Infec Dis Treat

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In Mexico, Meningococcal Disease (MD) is considered to be a rare disease; however, several studies done using active surveillance have proved the opposite. Since October-2005 until September-2016 (eleven years), active surveillance looking for all patients admitted with suspected MD<16 years of age was performed at the Tijuana, Mexico, General Hospital. There were 51 MD cases, with 21 (41.18%) < 2 years old. At admission, 47 (92.15%) had meningitis, 24 (47%) purpura, 4 (7.84%) conjunctivitis and 2 (3.92%) pleural effusion. Serogroup distribution was as follows: C-32 (62.74%), Y-12 (23.53%), B-5 (9.8%) and Ignored-2 (3.92%). Overall mortality was of 13 (25.49%). Among survivors (n=38), 13 (34.2%) developed sequelae. Yearly average MD attack rates were of 7.61 and 2.69 per 100, 000 populations in children<2 and <16 years of age, respectively. MD is endemic in Tijuana, Mexico. Meningococcal vaccination should be seriously considered in the region.

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Section: Introductionmentioning

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Chacón-Cruz¹,

Alvelais-Palacios²,

Lopatynsky-Reyes³

et al. 2017

J Infec Dis Treat

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“…MD is endemic in the region, even with the presence of an outbreak during 2013 (“discussed by us, Chacon-Cruz et al [1, 2]”).…”

Section: Case Presentationmentioning

confidence: 99%

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

Chacón-Cruz

Alvelais-Palacios

Rodriguez-Valencia

et al. 2017

Case Reports in Infectious Diseases

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Neonatal conjunctivitis is usually associated with vagina's infection by Chlamydia sp., N. gonorrhoeae, and/or other bacteria during delivery. Meningococcal neonatal conjunctivitis is an extremely rare disease. We report a case of neonatal meningococcal sepsis/conjunctivitis and asymptomatic carriage of N. meningitidis from both parents (vagina and nasopharynx). As part of our active surveillance for meningococcal disease at the Tijuana General Hospital (TGH), Mexico, we identified a 3-day-old newborn with meningococcal conjunctivitis and sepsis. The patient had a one-day history of conjunctivitis and poor feeding. Clinical examination confirmed profuse purulent conjunctival discharge, as well as clinical signs and laboratory findings suggestive of bacteraemia. Gram stain from conjunctival exudate revealed intracellular Gram negative diplococci; we presumed the baby had gonorrheal conjunctivitis; however, serogroup Y, N. meningitidis was isolated both from conjunctival exudate and blood. Additionally, isolation of serogroup Y, N. meningitidis was obtained from mother's vagina and both parents' nasopharynx. The baby was treated with 7 days of IV ceftriaxone and discharged with no sequelae.

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“…UU. durante 2005-2008 revela una presencia importante de casos de serogrupo Y, particularmente en el lado mexicano 22 . Por lo tanto, puede concluirse que el paso necesario hacia América Central se produjo, pero los sistemas de vigilancia no fueron capaces de detectarlo.…”

Section: Dinámica De La Epidemiología De Enfermedad Meningocócica Invunclassified

Vacunas multivalentes frente a enfermedad meningocócica: ¿dentro o fuera de nuestras agendas?

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2014

Anales de Pediatría

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Surveillance for Invasive Meningococcal Disease in Children, US–Mexico Border, 2005–20081

Cited by 21 publications

References 9 publications

Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Meningococcal Disease in Children: Eleven Years of Active Surveillance in a Mexican Hospital and the Need for Vaccination in the Tijuana Region

Meningococcal Neonatal Purulent Conjunctivitis/Sepsis and Asymptomatic Carriage of N. meningitidis in Mother’s Vagina and Both Parents’ Nasopharynx

Vacunas multivalentes frente a enfermedad meningocócica: ¿dentro o fuera de nuestras agendas?

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