In the process of work an assessment of the characteristics of the epizootic manifestation of quarantine diseases of animals and poultry as well as the risks of their occurrence and spread were made. On the territory of the Russian Federation are registered more than 30 nosological forms of infections, infestations and foodborne toxicological infections. According to the research, the epizootic situation in Krasnodar region regarding quarantine infections remains stable, despite the registration of 755 adverse areas for quarantine infections over a 10 year observation period. Since 2013, the number of adverse areas has decreased from 119 to 32. A similar trend is observed in the decrease in the linear trend of the focal incidence from 102.3 to 10.1. The highest focal index for the study period was found in cases of avian influenza 112.9, African swine fever 105.3 and bovine leucosis -55.8. An increased risk of the occurance of the diseases of this group on the territory of Krasnodar region exists in marchapril-may, june and august.