Surveillance of adverse events following vaccination in the French armed forces, 2011–2012

Mayet, Aurélie; Duron, Sandrine; Meynard, Jean‐Baptiste; Koeck, Jean-Louis; Deparis, Xavier; Migliani, R.

doi:10.1016/j.puhe.2015.03.003

Cited by 9 publications

(6 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No new safety concerns were identified in the studies reported in this review. Large post-marketing safety studies that include more than 55,000 individuals vaccinated with MenACWY-CRM [57][58][59], have confirmed the overall good safety profile identified during clinical development, and support the favorable benefit-risk ratio in all age groups.…”

Section: Expert Commentarymentioning

confidence: 63%

See 1 more Smart Citation

An update of clinical experience with the quadrivalent meningococcal ACWY-CRM conjugate vaccine

Keshavan¹,

Pellegrini²,

Vadivelu-Pechai

et al. 2018

Expert Review of Vaccines

View full text Add to dashboard Cite

Menveo, quadrivalent meningococcal ACWY-CRM conjugate vaccine, was first licensed in 2010 in the United States and has a long track record of immunogenicity and safety in all age groups, including infants from 2 months of age. Areas covered: This review presents clinical and post-marketing experience with MenACWY-CRM from 32 studies conducted in 20 countries that included individuals aged from 2 months to 75 years. Expert commentary: This decade has seen an increased number of countries reporting serogroup W ST-11 clonal complex outbreaks of invasive meningococcal disease. As infant vaccination programs targeting the meningococcus are reevaluated, the role of quadrivalent meningococcal vaccines including MenACWY-CRM will be expanded. MenACWY-CRM was immunogenic in all populations and age groups studied, regardless of country of origin. MenACWY-CRM can be coadministered with many routinely used infant, toddler and adolescent vaccines, and traveler vaccines in adults, allowing for flexible use within national immunization programs and recommendations. Antibody persistence has been demonstrated up to 5 years post vaccination in all age groups. Booster doses induced robust increases in antibody titers for all four serogroups, indicative of effective priming and induction of immunological memory. The acceptable safety profile of MenACWY-CRM has been confirmed in large post-marketing safety studies.

show abstract

Section: Expert Commentarymentioning

confidence: 63%

“…A safety surveillance of AEs after vaccination of the French military personnel identified 47 AEs after vaccination with MenACWY-CRM between 2011 and 2012; none of which was serious. A total of 119,640 MenACWY-CRM doses were administered during the surveillance period [57]. No safety concerns were raised.…”

Section: Post-marketing Experience Using Acwy-crmmentioning

confidence: 99%

An update of clinical experience with the quadrivalent meningococcal ACWY-CRM conjugate vaccine

Keshavan¹,

Pellegrini²,

Vadivelu-Pechai

et al. 2018

Expert Review of Vaccines

View full text Add to dashboard Cite

show abstract

“…Tandem duplication and segmental genome duplication are major contributors to the generation and maintenance of the GiHDMT families. If two paralogous genes are physically adjacent, we infer them arising through tandem duplication 27 . We found that four gene pairs ( GiHDMT5 and GiHDMT6 , GiHDMT12 and GiHDMT14 , GiHDMT20 and GiHDMT23 , GiHDMT31 and GiHDMT34 ) were tandemly distributed on the chromosome with high nucleotide similarity (>69%) and high amino‐acid similarity (>55%), which indicates that these four gene pairs may have undergone tandem duplication during evolution (Figure 3).…”

Section: Resultsmentioning

confidence: 96%

“…If two paralogous genes are physically adjacent, we infer them arising through tandem duplication. 27 We found that four gene pairs (GiHDMT5 and GiHDMT6, GiHDMT12 and GiHDMT14, GiHDMT20 and GiHDMT23, GiHDMT31 and GiHDMT34) were tandemly distributed on the chromosome with high nucleotide similarity (>69%) and high amino-acid similarity (>55%), which indicates that these four gene pairs may have undergone tandem duplication during evolution (Figure 3). We further investigated whether segmental duplications contributed to the expansion of the HDMT family in licorice.…”

Section: Chromosomal Localization and Duplications Of Gihdmt Genesmentioning

confidence: 94%

Identification of the histone demethylases gene family in Glycyrrhiza inflata reveals genes responding to abiotic stresses

Zhuang

Zeng

et al. 2022

J of Cellular Biochemistry

View full text Add to dashboard Cite

Glycyrrhiza inflata Bat. is a type of abiotic‐stress‐resistant plant with extremely high medicinal value. Histone demethylases (HDMTs) have been known to play crucial roles in the regulation of abiotic stress response. However, the molecular functions of HDMTs has not been studied in G. inflata. Here we identified 34 GiHDMT genes in G. inflata, which could be divided into the 6 groups through phylogenetic analysis. We further found that the gene structure and conserved protein motifs exhibit high conservation in each group of GiHDMT genes. Various abiotic‐stress‐related elements are detected in GiHDMT promoters, especially for the light‐responsive element and abscisic acid‐responsive element. Collinearity analysis indicated that segmental duplication contributed to the expansion of the GiHDMT family in licorice. Subcellular localization analysis revealed that green fluorescent protein‐tagged GiHDMT2 and GiHDMT18 were predominantly localized in the nucleus, whereas GiHDMT1 were found in both the cytoplasm and nucleus. Real‐time quantitative polymerase chain reaction showed that GiHDMTs presented differential expression patterns across different tissues. Moreover, changes in transcription level of GiHDMTs under abiotic stress indicate the potential role of GiHDMTs in the stress response in licorice. Finally, we found the histone methylation levels probably mediated by GiHDMT genes are changed with the treatment of NaCl and Na2CO3. Our study will lay the foundation for future research on the regulatory roles of GiHDMT genes in the environmental stress.

show abstract

“…These two AEs were also found in our study. Retrospective BCG AE studies were also conducted in many other countries, for example, Brazil [ 30 ], French [ 31 ], Ireland [ 32 ], Singapore [ 33 ], and China (paper written in Chinese) [ 34 ]. The BCG AEs reported in these literature articles were collected in our literature meta-analysis study and analyzed again.…”

Section: Discussionmentioning

confidence: 99%

Differential Adverse Event Profiles Associated with BCG as a Preventive Tuberculosis Vaccine or Therapeutic Bladder Cancer Vaccine Identified by Comparative Ontology-Based VAERS and Literature Meta-Analysis

Xie

Codd

et al. 2016

PLoS ONE

View full text Add to dashboard Cite

M. bovis strain Bacillus Calmette–Guérin (BCG) has been the only licensed live attenuated vaccine against tuberculosis (TB) for nearly one century and has also been approved as a therapeutic vaccine for bladder cancer treatment since 1990. During its long time usage, different adverse events (AEs) have been reported. However, the AEs associated with the BCG preventive TB vaccine and therapeutic cancer vaccine have not been systematically compared. In this study, we systematically collected various BCG AE data mined from the US VAERS database and PubMed literature reports, identified statistically significant BCG-associated AEs, and ontologically classified and compared these AEs related to these two types of BCG vaccine. From 397 VAERS BCG AE case reports, we identified 64 AEs statistically significantly associated with the BCG TB vaccine and 14 AEs with the BCG cancer vaccine. Our meta-analysis of 41 peer-reviewed journal reports identified 48 AEs associated with the BCG TB vaccine and 43 AEs associated with the BCG cancer vaccine. Among all identified AEs from VAERS and literature reports, 25 AEs belong to serious AEs. The Ontology of Adverse Events (OAE)-based ontological hierarchical analysis indicated that the AEs associated with the BCG TB vaccine were enriched in immune system (e.g., lymphadenopathy and lymphadenitis), skin (e.g., skin ulceration and cyanosis), and respiratory system (e.g., cough and pneumonia); in contrast, the AEs associated with the BCG cancer vaccine mainly occurred in the urinary system (e.g., dysuria, pollakiuria, and hematuria). With these distinct AE profiles detected, this study also discovered three AEs (i.e., chills, pneumonia, and C-reactive protein increased) shared by the BCG TB vaccine and bladder cancer vaccine. Furthermore, our deep investigation of 24 BCG-associated death cases from VAERS identified the important effects of age, vaccine co-administration, and immunosuppressive status on the final BCG-associated death outcome.

show abstract

Surveillance of adverse events following vaccination in the French armed forces, 2011–2012

Cited by 9 publications

References 16 publications

An update of clinical experience with the quadrivalent meningococcal ACWY-CRM conjugate vaccine

An update of clinical experience with the quadrivalent meningococcal ACWY-CRM conjugate vaccine

Identification of the histone demethylases gene family in Glycyrrhiza inflata reveals genes responding to abiotic stresses

Differential Adverse Event Profiles Associated with BCG as a Preventive Tuberculosis Vaccine or Therapeutic Bladder Cancer Vaccine Identified by Comparative Ontology-Based VAERS and Literature Meta-Analysis

Contact Info

Product

Resources

About