Surveillance of group A Rotavirus in Buenos Aires 2008–2011, long lasting circulation of G2P[4] strains possibly linked to massive monovalent vaccination in the region

Mandile, Marcelo Gastón; Esteban, Laura Emilia; Argüelles, Marcelo Horacio; Mistchenko, Alicia; Glikmann, Graciela; Castello, Alejandro

doi:10.1016/j.jcv.2014.04.022

Cited by 16 publications

(17 citation statements)

References 32 publications

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“…These findings fit within a regional trend of decreased G1 prevalence in bordering Brazil and Argentina during the same period. 3,37 As seen in Argentina, we saw high prevalence of G3P [8] and G2P [4] genotypes. 3 Similar to Brazilian and Argentine populations, Bolivia experienced an increase in G2P [4] genotypes immediately before vaccine introduction, suggesting year-to-year variability toward this genotype.…”

Section: Discussionsupporting

confidence: 51%

“…3,37 As seen in Argentina, we saw high prevalence of G3P [8] and G2P [4] genotypes. 3 Similar to Brazilian and Argentine populations, Bolivia experienced an increase in G2P [4] genotypes immediately before vaccine introduction, suggesting year-to-year variability toward this genotype. 5,6,37 The G1P [8]-derived vaccine is effective against genotypes heterotypic to the vaccine type, including the G2P [4] genotype that some have suggested is favored after vaccination.…”

Section: Discussionsupporting

confidence: 51%

“…[40][41][42][43] Waning immunity to G2P [4] in the second year of life has been suggested as a means by which the genotype may persist at higher levels in vaccinated populations. 3 Despite any theoretical influence by vaccine, our data suggest that regional circulation patterns remain highly influential on detected genotypes. As mentioned, the most common genotype detected, G3P [8] was also highly prevalent in neighboring Argentina during the same period.…”

Section: Discussionmentioning

confidence: 69%

“…As mentioned, the most common genotype detected, G3P [8] was also highly prevalent in neighboring Argentina during the same period. 3 As is the case with other partially homotypic genotypes, Rotarix is highly effective against G3P [8]. 10 Extensive analysis has not demonstrated any genotype-specific variability in rotavirus gastroenteritis because of vaccine.…”

Section: Discussionmentioning

confidence: 99%

“…2 Norovirus and rotavirus are the major causes of diarrheal illness in South American children. [3][4][5][6][7][8][9] Recent data suggest that the relative burden of norovirus versus rotavirus in children with AGE may be changing after widespread adoption of rotavirus vaccine. Relatively little is known of viral etiology of pediatric AGE in low income, high mortality settings after vaccine introduction.…”

Section: Introductionmentioning

confidence: 99%

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Burden of Norovirus and Rotavirus in Children After Rotavirus Vaccine Introduction, Cochabamba, Bolivia

McAtee¹,

Webman²,

Gilman³

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. The effectiveness of rotavirus vaccine in the field may set the stage for a changing landscape of diarrheal illness affecting children worldwide. Norovirus and rotavirus are the two major viral enteropathogens of childhood. This study describes the prevalence of norovirus and rotavirus 2 years after widespread rotavirus vaccination in Cochabamba, Bolivia. Stool samples from hospitalized children with acute gastroenteritis (AGE) and outpatients aged 5-24 months without AGE were recruited from an urban hospital serving Bolivia's third largest city. Both viruses were genotyped, and norovirus GII.4 was further sequenced. Norovirus was found much more frequently than rotavirus. Norovirus was detected in 69/201 (34.3%) of specimens from children with AGE and 13/71 (18.3%) of those without diarrhea. Rotavirus was detected in 38/201 (18.9%) of diarrheal specimens and 3/71 (4.2%) of non-diarrheal specimens. Norovirus GII was identified in 97.8% of norovirus-positive samples; GII.4 was the most common genotype (71.4% of typed specimens). Rotavirus G3P [8] was the most prevalent rotavirus genotype (44.0% of typed specimens) and G2P [4] was second most prevalent (16.0% of typed specimens). This community is likely part of a trend toward norovirus predominance over rotavirus in children after widespread vaccination against rotavirus.

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