Surveillance of Neisseria meningitidis carriage four years after menACWY vaccine implementation in the Netherlands reveals decline in vaccine-type and rise in genogroup e circulation

Miellet, Willem R.; Pluister, Gerlinde N.; Sikking, Meike; Tappel, Marcia; Karczewski, Jakub; Visser, Lenneke de; Bosch, Thijs; Trzciński, Krzysztof; Mariman, Rob

doi:10.1016/j.vaccine.2023.06.078

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…In Europe, the majority of IMD cases are caused by MenB, with MenW, MenC, and MenY also causing disease [45]. MenC and MenW previously accounted for a greater share of disease in the region, but incidence declined following successful vaccination campaigns using the conjugate polysaccharide vaccine against MenACWY [46][47][48]. North America exhibits similar serogroup prevalence to that of Europe, with a slightly higher proportion of MenC cases in the United States [45].…”

Section: Meningococcal Diversity Epidemiology and Invasive Potentialmentioning

confidence: 99%

“…Similarly, MenB and MenY remain a major cause of disease in Europe and North America following successful reductions in the burden of MenC and MenW by vaccination [9]. A rise in MenB, MenE, and MenX carriage was recently reported in the Netherlands four years after the implementation of the MenACWY vaccine [48]. Whether these trends are reflective of selection for nonvaccine serogroups, the expansion of existing lineages into the niche left by the vaccine-controlled serogroups, or simply a part of the normal cycling of dominant meningococcal lineages is not clear.…”

Section: Streptococcus Iniaementioning

confidence: 99%

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Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

Mikucki,

Kahler

2023

Microorganisms

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Neisseria meningitidis is commensal of the human pharynx and occasionally invades the host, causing the life-threatening illness invasive meningococcal disease. The meningococcus is a highly diverse and adaptable organism thanks to natural competence, a propensity for recombination, and a highly repetitive genome. These mechanisms together result in a high level of antigenic variation to invade diverse human hosts and evade their innate and adaptive immune responses. This review explores the ways in which this diversity contributes to the evolutionary history and population structure of the meningococcus, with a particular focus on microevolution. It examines studies on meningococcal microevolution in the context of within-host evolution and persistent carriage; microevolution in the context of meningococcal outbreaks and epidemics; and the potential of microevolution to contribute to antimicrobial resistance and vaccine escape. A persistent theme is the idea that the process of microevolution contributes to the development of new hyperinvasive meningococcal variants. As such, microevolution in this species has significant potential to drive future public health threats in the form of hypervirulent, antibiotic-resistant, vaccine-escape variants. The implications of this on current vaccination strategies are explored.

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Section: Meningococcal Diversity Epidemiology and Invasive Potentialmentioning

confidence: 99%

Section: Streptococcus Iniaementioning

confidence: 99%

Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

Mikucki,

Kahler

2023

Microorganisms

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Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review

Shen,

Findlow,

Peyrani

2024

Infect Dis Ther

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affecting younger age groups. Spread of serogroup C clonal complex-11 IMD in the 1990s prompted implementation of MenC vaccine programs in many countries, resulting in declines in prevalence. Serogroup C still caused > 20% of global IMD through the mid-2010s. Serogroup W became a significant contributor to global IMD after Hajj pilgrimage outbreaks in 2000; subsequent increases of endemic disease and outbreaks were reported pre-pandemic in many regions. Serogroup Y emerged in the 1990s as a significant cause of IMD throughout various regions and prevalence had increased or stabilized from 2010 to 2018. Serogroup X is uncommon outside the African meningitis belt, and its prevalence has declined since before the COVID-19 pandemic. Global IMD declines during the pandemic were followed by resurgences generally caused by serogroups that were prevalent pre-pandemic and affecting mainly unvaccinated age groups (particularly adolescents/ young adults). Recent IMD epidemiology underscores the importance of vaccinating at-risk age groups against regionally prevalent serogroups; for example, the anti-serogroup X component of the recently prequalified MenACWXY vaccine is likely to provide limited protection outside the African meningitis belt. In other regions, comprehensive vaccination against MenB and MenACWY, which could be streamlined by the recently approved MenABCWY vaccine, seems more appropriate.

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Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe

Borrow,

Campbell,

Caugant

et al. 2024

Journal of Infection

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Surveillance of Neisseria meningitidis carriage four years after menACWY vaccine implementation in the Netherlands reveals decline in vaccine-type and rise in genogroup e circulation

Cited by 4 publications

References 19 publications

Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

Microevolution and Its Impact on Hypervirulence, Antimicrobial Resistance, and Vaccine Escape in Neisseria meningitidis

Global Epidemiology of Meningococcal Disease-Causing Serogroups Before and After the COVID-19 Pandemic: A Narrative Review

Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe

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