Surveillance of viral infections in renal transplant recipients – A prospective observational study

Rao, Akhilesh; Konnur, Abhijit; Gang, Sishir; Hegde, Umapati; Soni, Shailesh; Jojera, Amit

doi:10.4103/ijot.ijot_73_19

Cited by 3 publications

(4 citation statements)

References 29 publications

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“…The incidence of CMV infection within 1‐year posttransplantation was described in 16 studies, with rates ranging from 10.3% to 63.2% in studies including recipients with various serostatus and in which use of CMV preventive strategy was based on CMV serostatus, also called CMV risk group (9 studies) 21–29 . (Figure S1).…”

Section: Resultsmentioning

confidence: 99%

“…The diagnostic criteria used for ascertaining CMV infection were similar across studies—whereby a patient was considered to have CMV infection through a positive PCR and/or pp65‐antigenemia assay for CMV. However, specimens used for these analyses varied extensively, consisting of either whole blood, plasma, serum, or body fluid, collected periodically during CMV monitoring (frequency and duration of monitoring were not reported) 21–22,24–26,28–35,37,40,41 . In addition, thresholds used to determine whether a patient was positive on the quantitative PCR assay were heterogeneous—such as ≥500 copies/mL (South Korea), 31 ≥1000 copies/mL (India), 24 or >2.500 international units (Brazil) 8,41 .…”

Section: Resultsmentioning

confidence: 99%

“…(Figure S1). In patients receiving prophylaxis (5 studies), reported rates of CMV infection during the first year post‐SOT were 5.2%, 30 26.0%, 24 45.4%, 31 50.0%, 22 and 50.2% 32 . According to studies conducted in Brazil, India, and South Korea, infection typically appeared after a median of 1–2 months postkidney or postliver transplantation 8,21,25,27,29,32–39 .…”

Section: Resultsmentioning

confidence: 99%

“…However, specimens used for these analyses varied extensively, consisting of either whole blood, plasma, serum, or body fluid, collected periodically during CMV monitoring (frequency and duration of monitoring were not reported) 21–22,24–26,28–35,37,40,41 . In addition, thresholds used to determine whether a patient was positive on the quantitative PCR assay were heterogeneous—such as ≥500 copies/mL (South Korea), 31 ≥1000 copies/mL (India), 24 or >2.500 international units (Brazil) 8,41 . Stratification of infection rates by diagnostic method or by type of organ transplanted did not uncover any apparent trends (Figure S2).…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review

Silva

Tokat

Cai

et al. 2023

Transplant Infectious Dis

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BackgroundCytomegalovirus (CMV) is a frequent infectious complication following solid organ transplantation (SOT). Considering significant differences in healthcare systems, a systematic review was conducted to describe the epidemiology, management, and burden of CMV post‐SOT in selected countries outside of Europe and North America.MethodsMEDLINE, Embase, and Cochrane databases were searched for observational studies in SOT recipients across 15 countries in the regions of Asia, Pacific, and Latin America (search period: January 1, 2011 to September 17, 2021). Outcomes included incidence of CMV infection/disease, recurrence, risk factors, CMV‐related mortality, treatment patterns and guidelines, refractory and/or resistant CMV, patient‐reported outcomes, and economic burden.ResultsOf 2708 studies identified, 49 were eligible (n = 43/49; 87.8% in adults; n = 34/49, 69.4% in kidney recipients). Across studies, selection of CMV preventive strategy was based on CMV serostatus. Overall, rates of CMV infection (within 1 year) and CMV disease post‐SOT were respectively, 10.3%–63.2% (9 studies) and 0%–19.0% (17 studies). Recurrence occurred in 35.4%–41.0% cases (3 studies) and up to 5.3% recipients died of CMV‐associated causes (11 studies). Conventional treatments for CMV infection/disease included ganciclovir (GCV) or valganciclovir. Up to 4.4% patients were resistant to treatment (3 studies); no studies reported on refractory CMV. Treatment‐related adverse events with GCV included neutropenia (2%–29%), anemia (13%–48%), leukopenia (11%–37%), and thrombocytopenia (13%–24%). Data on economic burden were scarce. imageConclusionOutside of North America and Europe, rates of CMV infection/disease post‐SOT are highly variable and CMV recurrence is frequent. CMV resistance and treatment‐associated adverse events, including myelosuppression, highlight unmet needs with conventional therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review

Silva

Tokat

Cai

et al. 2023

Transplant Infectious Dis

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Basiliximab/rituximab

2020

Reactions Weekly

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Prevalence of viral hepatitis infection in India: A systematic review and meta-analysis

Joseph

Kumar²,

Peter³

et al. 2023

Journal of Education and Health Promotion

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BACKGROUND: Nowadays, Viral Hepatitis can be comparable to the big three communicable diseases: tuberculosis, HIV/AIDS, and malarial infections. The main purpose of this study was to summarize the prevalence of viral Hepatitis in India from peer-reviewed articles published from February 2000 to February 2021. MATERIALS AND METHODS: We conducted a systematic search on Science Direct, Scopus, Medline, PubMed, Web of Science, Google Scholar, and other open access journals. We evaluated all relevant papers that looked into the prevalence of viral Hepatitis systematically. Finally, 28 studies on viral Hepatitis published from February 2000 to February 2021 have been selected. These studies have been conducted across the northern, southern, central, eastern, and western regions of India. RESULTS: Twenty-eight full-text publications were obtained and evaluated consisting of 45,608 research participants. Hepatitis A was found to range from 2.1% to 52.5%. Hepatitis B was found in a wide range of individuals, ranging from 0.87% to 21.4% of the population. Hepatitis C was found to range from 0.57% to 53.7%. The majority of the children were affected by hepatitis A, and 47.4% of third-trimester pregnant mothers were affected by hepatitis E. Diabetes, hospital admission, history of jaundice, history of surgeries, and heterosexual contact were the leading modes of acquiring HBV and HCV infections. As a result of its great magnitude, this disease poses a severe threat to the national healthcare system. CONCLUSION: Effective public health measures are urgently needed to minimize the burden of viral Hepatitis and eliminate the disease.

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Surveillance of viral infections in renal transplant recipients – A prospective observational study

Cited by 3 publications

References 29 publications

Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review

Epidemiology, management, and burden of cytomegalovirus in solid organ transplant recipients in selected countries outside of Europe and North America: A systematic review

Basiliximab/rituximab

Prevalence of viral hepatitis infection in India: A systematic review and meta-analysis

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