Surveillance study on scorpion species in Egypt and comparison of their crude venom protein profiles

Salama, Wesam M.; Sharshar, Khadiga M.

doi:10.1016/j.jobaz.2013.10.003

Cited by 14 publications

(15 citation statements)

References 32 publications

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“…Minimum lethal dose and minimum effective dose were used to evaluate the effect of Turkish antivenom on M. gibbosus envenomation, suggesting the predictive validity, precision, and reliability of the new formula in envenomotherapy. Scorpion stings result in adult morbidity and pediatric mortality and the most lethal species are Tityus serrulatus and Tityus bahiensis in Brazil, Centruroides suffusus , Centruroides lionpidus , and Centruroides sculpturatus in Mexico, L. quinquestriatus , A. crassicauda , A. mauretanicus , A. australis , A. amoreuni , and Buthus occitanus in the Middle East and North Africa, Parabuthus grauntatus and Parabuthus transvaalicus in South Africa, and Mesobuthus tamulus and Palamneus swammerdance in India.…”

Section: Discussionmentioning

confidence: 99%

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Saganuwan

2018

Anim Models and Exp Med

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Background About 50 species of scorpions cause fatal scorpionism worldwide. Most of these are members of the Buthidae family, and include, among others, Mesobuthus eupeus , Androctonus crassicauda , Leiurus abdullahbayrami , Leiurus quinquestriatus , Tityus pachyurus and Androctonus australis . Because high doses of scorpion venom and antivenom can cause death and hypersensitive reactions, there is a need to develop a formula that can be used to calculate both lethal and effective doses for scorpion venom and antivenom, respectively, thereby obviating the need for laboratory experiments. Methods In view of this, a literature search was carried out with the aim of modifying the formula ( ) for calculation of the median lethal dose (LD 50 ) of scorpion venom and the ED 50 of antivenom. The human equivalent dose (HED) formula was assessed for extrapolation of LD 50 and ED 50 from animals to human for comparison and relevance with the new formula. Results The findings showed that the newly developed formula (LD 50 = ED 50 1/3 × W a × 10 −4 ) yielded results that are very close to the reported values. Therefore, the newly developed and HED formulas can be used for calculation of LD 50 and ED 50 values for scorpion venom and antivenom, respectively. Conclusion The new formula yielded better results than the HED formula, confirming its predictive validity, precision, and reliability, thereby obviating the need for rigorous experiments and justifying the principles of reduction, refinement, and replacement (3Rs).

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Section: Discussionmentioning

confidence: 99%

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Saganuwan

2018

Anim Models and Exp Med

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“…Scorpion sting results in adult morbidity and pediatric mortality [110]. The most lethal species are T. serrulatus, T. bahiensis in Brazil, Centruroides suffusus, C. lionpidus, C. sculpturatus in Mexico, Leiurus quinquestriatus, A. crassicauda, A. australis, A. amoreuni, Buthus occitanus in Middle East and North Africa, Parabuthus grauntatus and P. transvaalicus in South Africa, Mesobuthus tamulus and Palamneus swammerdance in India [111], respectively. One milliliter of Androctonus crassicauda antivenom could neutralize Mesobuthus eupeus venom.…”

Section: Treatment Of Scorpionismmentioning

confidence: 99%

Toxicosis of Snake, Scorpion, Honeybee, Spider, and Wasp Venoms: Part 1

Saganuwan¹

2021

Medical Toxicology

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Toxicosis is a poisoning caused by venomous animals such as snake, scorpion, honeybee, spider, and wasp. Their poisons contain amino acids, peptides, proteins, enzymes, and metallic ions that are responsible for neurotoxicity, hemotoxicity, and myotoxicity. Because of in vivo therapeutic challenges posed by toxicosis, there is need for ideal therapeutic agents against envenomation caused by venomous animals. Findings have shown that toxicosis could be treated symptomatically. Snake and scorpion antivenins could be used for treatment of poisoning caused by snake, scorpion, honeybee, spider, and wasp. The amount of antivenin is dependent on the quantity of venom injected into the affected individuals. More so, symptomatic treatments are also done according to the systems affected. Hospitalization is necessary for assessment of therapeutic success.

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“…The scorpion activity period in Egypt is warm months and these environmental conditions explained the nature of scorpions (Hmimou et al, 2008). Salama and Sharshar (2013) were interested in study on scorpions from different regions in Egypt. Saleh et al (2017) studied the geographical distribution and diversity of the scorpion fauna in Egypt.…”

Section: Introductionmentioning

confidence: 99%

“…Whereas Abd-el-Wahab (1957) studied the morphological and histological description of the male genital system of the scorpion Buthus quinquestriatus. Venom and the composition of the poisonous gland were studied by Salama and Sharshar (2013). Abd El-Atti et al (2020) described the morphology, histology, histochemistry and ultrastructure of the venom gland of Leiurus quinquestriatus.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure Study on The Exo-Morphology of Four Species of Scorpion Inhabiting New Valley, Egypt

Said

Obuid-Allah

El-Shimy

et al. 2021

Egyptian Academic Journal of Biological Sciences, B. Zoology

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Scorpionsare terrestrial arthropods inhabiting deserts. Exomorghological studies play an important role in the identification of different scorpions' species. The current study deals with the ecomorphology of four species of scorpions belong to the family buthidae (Leiurus quinquestriatus, Androctonus amoreuxi, Orthochirus innesi and Buthacus leptochelys) inhabiting New Valley governorate, Egypt. Random samples were implemented during the period from April to July, 2017 and July to September, 2019. Scorpions were obtained from the area under rocks, gap of soil, leaf litter, under bark, and within vegetation. Morphological characteristics of these species were done using a scanning electron microscope (SEM). In conclusion, the differences among four species of studied scorpions were noticed in the dorsal carapace, respiratory pores of the third segment of mesosoma, pectinal teeth count between females and males, last segment of metasoma and telson. In all scorpions' species studied, one venom pore was detected except in Androctonus amoreuxi two venom pores in telson were observed.

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Surveillance study on scorpion species in Egypt and comparison of their crude venom protein profiles

Cited by 14 publications

References 32 publications

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Toxicosis of Snake, Scorpion, Honeybee, Spider, and Wasp Venoms: Part 1

Ultrastructure Study on The Exo-Morphology of Four Species of Scorpion Inhabiting New Valley, Egypt

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Surveillance study on scorpion species in Egypt and comparison of their crude venom protein profiles

Cited by 14 publications

References 32 publications

Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED50) of scorpion antivenom against scorpion envenomation using a newly developed formula

Toxicosis of Snake, Scorpion, Honeybee, Spider, and Wasp Venoms: Part 1

Ultrastructure Study on The Exo-Morphology of Four Species of Scorpion Inhabiting New Valley, Egypt

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Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula

Determination of median effective dose (ED₅₀) of scorpion antivenom against scorpion envenomation using a newly developed formula