Surveilling and Tracking COVID-19 Patients Using a Portable Quantum Dot Smartphone Device

The application of quantum dots (QDs) for detecting and treating various types of coronaviruses is very promising, as their low toxicity and high surface performance make them superior among other nanomaterials; in conjugation with fluorescent probes they are promising semiconductor nanomaterials for the detection of various cellular processes and viral infections. In view of the successful results for inhibiting SARS‐CoV‐2, functional QDs could serve eminent role in the growth of safe nanotherapy for the cure of viral infections in the near future; their large surface areas help bind numerous molecules post‐synthetically. Functionalized QDs with high functionality, targeted selectivity, stability and less cytotoxicity can be employed for highly sensitive co‐delivery and imaging/diagnosis. Besides, due to the importance of safety and toxicity issues, QDs prepared from plant sources (e.g. curcumin) are much more attractive, as they provide good biocompatibility and low toxicity. In this review, the recent developments pertaining to the diagnostic and inhibitory potentials of QDs against SARS‐CoV‐2 are deliberated including important challenges and future outlooks. © 2022 Society of Chemical Industry (SCI).

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“…This introduced appliance and assay allow real‐time evaluation of SARS‐CoV‐2 infection (analysis of immunity). 52 …”

Section: Qds Against Sars‐cov ‐2: Diagnos...mentioning

confidence: 99%

Quantum dots against SARS‐CoV‐2: diagnostic and therapeutic potentials

Rabiee

Ahmadi

Soufi

et al. 2022

J of Chemical Tech & Biotech

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“…Reprinted (adapted) from Ref. [222] with permissions of American Chemical Society magnitude of shifting is directly proportional to the number of molecules bound to the resonator surface, allowing for direct quantification. Chips were tailored to either detect SARS-CoV 2 spike protein or human COVID-19 Ig's together with additional supplied bovine serum albumin serving as an internal reference for correct shift estimations [221].…”

Section: Photonic Solutions For Longitudinal Monitoring Of Vaccine Ef...mentioning

confidence: 99%

“…The signal detection via a simple smartphone infrared camera dramatically reduces price, size and test duration compared with equally performing ELISA systems. Zhang et al presented another smart‐phone based serological assay device [222]. Here, the target molecules are captured by antigen‐coated, spectrally barcoded quantum dot microbeads followed by binding of fluorophore‐conjugated secondary antibodies as depicted in Figure 19D [222].…”

Section: Photonic Solutions For Longitudinal Monitoring Of Vaccine Ef...mentioning

confidence: 99%

“…Zhang et al presented another smart‐phone based serological assay device [222]. Here, the target molecules are captured by antigen‐coated, spectrally barcoded quantum dot microbeads followed by binding of fluorophore‐conjugated secondary antibodies as depicted in Figure 19D [222]. Interrogation of the resulting sandwich structure by laser excitation enables both the identification of individuals beads as well as the number of target molecules [222].…”

Section: Photonic Solutions For Longitudinal Monitoring Of Vaccine Ef...mentioning

confidence: 99%

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Understanding viruses and viral infections by biophotonic methods

Ramoji

Pahlow

Pistiki

et al. 2022

Transl Biophotonics

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In the last few decades outbreaks of viral infections have often challenged the world‐wide health infrastructure and caused a significant financial burden as well as human suffering despite progress in diagnostic technologies. The recent outbreaks of the Ebola virus in the African continent, the Zika virus in the American continent, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS), influenza A and lately severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) viral infections have repeatedly highlighted the importance of technological advancement enabling a better understanding of virions. In this review, we systematically discuss different aspects of virions and how their properties and functions can be studied using different light‐based technologies. We focus on virion classification, detection and interactions with the host's immune system. Further, the potential of advanced biophotonic methods, for example, Raman, infrared reflection, absorption and fluorescence spectroscopy, advanced microscopic techniques and biosensor‐based approaches for diagnosing viral infections, investigating therapeutics and vaccine development are described. Although significant advancements have already been made in photonic technologies, which even enable visualizing virion‐host interactions on single‐cell level, the continuous evolution of viruses demands further progress in biophotonic solutions for fast, affordable and robust health monitoring devices for screening viral infections.

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“…[3][4][5][6][7][8] Using the mechanistic insight gained by elucidating reaction pathways, synthesis methods can grow colloidal NCs with precise control over these structural parameters, [9][10][11] potentiating the development of next-generation technologies in heterogeneous catalysis, chemical processing, photonics, sensing, medicine, and environmental remediation. [12][13][14][15][16][17][18][19] Hence, a key focus in the fields of chemistry, materials science, and nanoscience has been to understand how colloidal NCs grow.…”

Section: Introductionmentioning

confidence: 99%