Survey of digestive health across Europe: Final report. Part 2: The economic impact and burden of digestive disorders

Anderson, Pippa; Dalziel, Katie; Davies, Edward; Fitzsimmons, Deborah; Hale, Jessica; Hughes, Amanda; Isaac, Jeffrey C.; Onishchenko, Kateryna; Phillips, Ceri; Pockett, Rhys

doi:10.1177/2050640614554155

Cited by 19 publications

(12 citation statements)

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“…(1) These functional gastrointestinal diseases (FGIDs) impact on activities of daily living, reduce work-related productivity and incur high direct and indirect health care costs. (2) Indeed, although life expectancy is normal in FGID patients,(3) the burden of disease in terms of quality of life can be compared to those with cardiac failure or advanced malignancy. (4) The success of modern, scientific medicine is based on identifying and treating the pathophysiological basis of so-called organic disease (for example neoplasia, inflammation, achalasia and other major motility disorders).…”

Section: Rectocele -A Herniation (Bulge) Of the Front (Anterior) Wallmentioning

confidence: 99%

Clinical measurement of gastrointestinal motility and function: who, when and which test?

Fox

Kahrilas

Roman

et al. 2018

Nat Rev Gastroenterol Hepatol

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Symptoms related to abnormal gastrointestinal motility and function are common. Oropharyngeal and oesophageal dysphagia, heartburn, bloating, abdominal pain and alterations in bowel habits are among the most frequent reasons for seeking medical attention from internists or general practitioners and are also common reasons for referral to gastroenterologists and colorectal surgeons. However, the nonspecific nature of gastrointestinal symptoms, the absence of a definitive diagnosis on routine investigations (such as endoscopy, radiology or blood tests) and the lack of specific treatments make disease management challenging. Advances in technology have driven progress in the understanding of many of these conditions. This Review serves as an introduction to a series of Consensus Statements on the clinical measurements of gastrointestinal motility, function and sensitivity. A structured, evidence-based approach to the initial assessment and empirical treatment of patients presenting with gastrointestinal symptoms is discussed, followed by an outline of the contribution of modern physiological measurement on the management of patients in whom the cause of symptoms has not been identified with other tests. Discussions include the indications for and utility of high-resolution manometry, ambulatory pH-impedance monitoring, gastric emptying studies, breath tests and investigations of anorectal structure and function in day-to-day practice and clinical management.

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Section: Rectocele -A Herniation (Bulge) Of the Front (Anterior) Wallmentioning

confidence: 99%

Clinical measurement of gastrointestinal motility and function: who, when and which test?

Fox

Kahrilas

Roman

et al. 2018

Nat Rev Gastroenterol Hepatol

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“…Alcohol consumption is a major public health concern, and Europe has the highest levels of active drinkers in the world. According to the previously published Unit-ed European Gastroenterology Survey of Digestive Health across Europe, 155 billion EUR are spent every year as a result of alcohol misuse [1]. Alcohol drinking is also considered a well-established risk factor of acute and chronic pancreatitis contributing to between 50 and 80% of all cases (with regional differences in prevalence) [2].…”

Section: Introductionmentioning

confidence: 99%

What Do We Currently Know about the Pathophysiology of Alcoholic Pancreatitis: A Brief Review

et al. 2020

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Background: Alcoholic pancreatitis is a serious medical concern worldwide and remains to be one of the common causes of pancreatic disease. Summary: While alcohol consumption causes direct damage to pancreatic tissue, only a small percentage of active drinkers will develop pancreatitis. An explanation of this phenomenon is probably that alcohol increases pancreatic vulnerability to damage; however, the simultaneous presence of additional risk factors and pancreatic costressors is required to increase the risk of pancreatitis and its complications caused by alcohol misuse. Recently, a number of important genetic as well as environmental factors influencing the risk of alcoholic pancreatitis have been described. Key Messages: In brief, this review reports established factors for the development of alcoholic pancreatitis and summarizes recent progress made in basic and clinical research.

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“…Euro Kosten aufgrund Abwesenheit vom Arbeitsplatz) führt und hohe Kosten im Gesundheitssystem (geschätzte Kosten 2011: 4,8 Mrd. Euro) verursacht [4,5].…”

Section: Introductionunclassified

Die Acid Pocket: ein neues Ziel für die Behandlung der gastroösophagealen Refluxkrankheit

Sauter¹,

Fox²

2018

Z Gastroenterol

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ZusammenfassungDie gastroösophageale Refluxkrankheit stellt die häufigste Ursache für Symptome des oberen Gastrointestinaltrakts dar.Der Säure-Reflux in der postprandialen Phase ist der prädominante Faktor der gastroösophagealen Refluxkrankheit (gastro-esophageal Reflux disease, GERD) und führt zu Beschwerden wie Sodbrennen und saurem Aufstoßen. Die chronische Säureexposition des Ösophagus führt zudem zu Komplikationen wie der Refluxösophagitis, peptischen Stenosen, dem Barrett-Ösophagus oder dem Adenokarzinom.Das Ausmaß an mukosalen Schäden und Symptomen hängt von zwei Hauptfaktoren ab: (1.) dem Säuregehalt des Refluxats, welches primär von der gastralen Säureproduktion und der Verteilung der Säure im Magen abhängt sowie (2.) der Häufigkeit / Dauer an Refluxepisoden und der Stärke der Refluxbarriere am gastroösophagealen Übergang. Das Konzept der Acid Pocket ist ein Versuch, diese Faktoren in einem gemeinsamen Pathomechanismus zu vereinen.Die Acid Pocket beschreibt eine Ansammlung von Magensäure am gastroösophagealen Übergang in der postprandialen Phase und stellt ein wichtiges Reservoir für gastroösophageale Refluxepisoden dar. Die Acid Pocket ist sowohl bei Gesunden wie auch bei Refluxpatienten vorhanden. Insbesondere bei Patienten mit einer Hiatushernie und / oder einem hypotensiven unteren Ösophagus-Sphinkter kann sich die Acid Pocket aber über den gastroösophagealen Übergang hinaus in den distalen Ösophagus ausbreiten, was zu einer erhöhten Säureexposition insbesondere des distalsten Ösophagus-Abschnitts und somit Refluxbeschwerden führt.In den letzten Jahren wurde die Acid Pocket als mögliches Ziel von pharmakologischen und chirurgischen GERD-Therapien postuliert. Säurehemmende Medikamente wie z. B. Protonen-Pumpen-Inhibitoren reduzieren den Säuregehalt der Acid Pocket, wogegen Alginat-Substanzen, Prokinetika und die Fundoplikatio-Operation die Acid Pocket nach distal weg vom gastroösophagealen Übergang dislozieren.

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Survey of digestive health across Europe: Final report. Part 2: The economic impact and burden of digestive disorders

Cited by 19 publications

References 0 publications

Clinical measurement of gastrointestinal motility and function: who, when and which test?

Clinical measurement of gastrointestinal motility and function: who, when and which test?

What Do We Currently Know about the Pathophysiology of Alcoholic Pancreatitis: A Brief Review

Die Acid Pocket: ein neues Ziel für die Behandlung der gastroösophagealen Refluxkrankheit

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