Survey of gadolinium-based contrast agent utilization among the members of the Society for Pediatric Radiology: a Quality and Safety Committee report

Blumfield, Einat; Moore, Michael J.; Drake, Mary K.; Goodman, T. Rob; Lewis, Kristopher Neal; Meyer, Laura T.; Ngo, Thang; Sammet, Christina L.; Stanescu, A. Luana; Swenson, David W.; Slovis, Thomas L.; Iyer, Ramesh S.

doi:10.1007/s00247-017-3807-z

Cited by 37 publications

(15 citation statements)

References 11 publications

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“…Gadolinium retention data affected the majority of radiologists in this survey. Nonetheless, in the English literature, very few studies are available on impact of emerging gadolinium retention data on daily radiology practice and gadolinium enhanced MRI exercises (27)(28)(29). Despite diversity in adopted methods and their small sample sizes, available studies' overall results are in line with our present study.…”

Section: Discussionsupporting

confidence: 83%

Gadolinium Retention in Humans: Survey of Radiologists and Impact on Daily Practice

Adin¹,

Yousem²

2021

jmed

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We sought to assess the 1) awareness and impact of emerging gadolinium retention data on preferences of radiologists in their practice, and 2) factors that influence the attitudes about gadolinium use and risk. This study also documents various specifics of radiology practice in Turkey. Methods: A twenty-one question survey was directed to radiologists who were at least one year from completion of residency and/or fellowship training. A survey link was emailed to the members of the Turkish Society of Radiology and was active for four weeks. The results were statistically analyzed. Results: Three hundred and thirty-five radiologists completed the survey. At the time of this survey, 89% of respondents were aware of gadolinium retention in the brain. Forty-five percent of respondents said they decreased the amount of gadolinium administered and/or frequency of gadolinium-enhanced scans since the emergence of the gadolinium retention data. Eightyeight percent of radiologists, who were aware of the molecular classification of different gadolinium agents, used a macrocyclic agent. Thirty-nine percent (n=130) had switched to a macrocyclic agent from a linear agent within the previous three years. Radiologists' attitudes toward gadolinium retention were significantly associated with their background factors such as experience in radiology, subspecialty training, and daily work definition, amongst others. Observence of hyperintense dentate nuclei due to gadolinium retention was uncommon in daily practice. Conclusions: Gadolinium retention publications have affected the practice of contrast enhanced Magnetic resonance imaging (MRI) scans, mostly in the form of switching to a macrocyclic gadolinium agent and decreasing utilization of gadolinium in general for some indications. These changes varied among radiologists by background factors.

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Section: Discussionsupporting

confidence: 83%

Gadolinium Retention in Humans: Survey of Radiologists and Impact on Daily Practice

Adin¹,

Yousem²

2021

jmed

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“…In a survey conducted by Meng and Grosse-Wortmann (26), 52 out of the 55 responders (cardiologists and radiologists) who performed scans in neonates aged less than 1 week, reported the use of GBCAs. According to a recent survey performed among the members of the Society for Pediatric Radiology (27), gadobutrol, gadoterate meglumine, and gadobenate dimeglumine were the most commonly used GBCAs (37.3%, 28.5%, and 26.0%, respectively) for neonates and infants younger than 1 year. Five post-marketing studies described the use of gadoterate meglumine in neonates and infants-the youngest patient being 3 days old (13).…”

Section: Image Qualitymentioning

confidence: 99%

Safety of gadoterate meglumine in over 1600 children included in the prospective observational SECURE study

Chang

Pracros

2019

Acta Radiol

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BackgroundTo date, few data on the safety profile of gadoterate meglumine in pediatric patients are available.PurposeTo assess the safety profile of gadoterate meglumine in routine practice, to detect any case of nephrogenic systemic fibrosis (NSF) suspicion and to collect efficacy data.Material and MethodsThe pediatric population of the observational SECURE study comprised 1631 patients scheduled for contrast-enhanced magnetic resonance imaging (MRI) with gadoterate meglumine (dose: 0.1 mmol/kg). Risk factors, MRI types and immediate adverse events (AEs) were systematically recorded. Patients with moderate to severe renal impairment were followed up for at least 3 months for detection of any NSF suspicion. Efficacy was assessed by the on-site radiologist in terms of image quality and ability to come to diagnosis.ResultsThe population included 106 children (6.5%) aged <2 years, 815 (50.0%) aged 2 to <12 years and 710 (43.5%) aged 12 to <18 years, with a mean (± SD) age of 10.2 (± 4.9) years. Central nervous system exploration was the most frequent MRI type (80.4%) and main risk factors were any stage of renal insufficiency (9.8%) and allergies (5.2%). Only one AE (vomiting) that was deemed doubtfully related to gadoterate meglumine was observed. No suspicions of NSF were reported. Good to very good image quality was obtained for 98.4% of pediatric patients and diagnosis was established in 99.6% of cases.ConclusionThis study confirmed the good safety profile of gadoterate meglumine in routine practice in a large pediatric population. The study is registered on https://clinicaltrials.gov/ with the identifier NCT01523873.

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“…Lanthanides are a group of metals with extensive use in biological research and medicine. [1][2][3][4] They are frequently used in clinical magnetic resonance imaging and, due to their spectroscopic properties, are powerful tools for probing physiological processes. For example, lanthanides have been used to monitor E-and N-cadherin dynamics in the membranes of cells undergoing epithelial-to-mesenchymal transition.…”

Section: Introductionmentioning

confidence: 99%

Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion

et al. 2019

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Survey of gadolinium-based contrast agent utilization among the members of the Society for Pediatric Radiology: a Quality and Safety Committee report

Abstract: Survey results demonstrate that GBCAs are administered judiciously in children, yet there is an opportunity to improve their utilization with the goal of reducing potential future adverse effects.

Cited by 37 publications

References 11 publications

Gadolinium Retention in Humans: Survey of Radiologists and Impact on Daily Practice

Gadolinium Retention in Humans: Survey of Radiologists and Impact on Daily Practice

Safety of gadoterate meglumine in over 1600 children included in the prospective observational SECURE study

Lanthanides compete with calcium for binding to cadherins and inhibit cadherin-mediated cell adhesion

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