Survey of materials for hard‐tissue prosthesis

Levine, S.

doi:10.1002/jbm.820050604

J. Biomed. Mater. Res.

1971

DOI: 10.1002/jbm.820050604

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Survey of materials for hard‐tissue prosthesis

S. Levine

Abstract: summaryThe properties of the three main classes of orthopedic alloys (316L steel, CoCr alloys and titanium) are discussed, while all show good general corrosion resistance, the 316L steel have a tendency toward crevice corrosion. Fatigue fracture due to poor design and fabrication defects is discussed. A summary of some problems associated with the evaluation of tissue response is presented, Finally, a review of several new trends toward achieving tissue adhesion is presented.

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1976

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Cited by 3 publications

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“…Bonding may be established either To achieve a high mechanical strength, the chemically or mechanically (5). Chemical bonds pore diameters in these ceramic materials should have been demonstrated for implants of certain be kept as small as possible (9). The pores must, glass formulations according to HENCH & however, at the same time be large enough to PASCHALL (4).…”

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confidence: 99%

Bone tissue formation within a sintered microporous glass‐fiber network implanted in extraction sockets in the rat

Ehrnford¹,

Sundström²,

Wallenius³

1980

European J Oral Sciences

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– Implants were prepared by sintering glass‐fibers into a three‐dimensional network with meshes smaller than 20 μm. Oblong 5x2x0.15 mm sheets of the test material were implanted in maxillary incisor alveoli in eight white rats. The alveoli were closed with a suture in the overlying mucosa. After 3 months the animals were sacrificed and sections from the site of implantation prepared. In three animals only root remnants were found but in the remaining five the implants were wholly or partially embedded in bone tissue. Sections studied with transmitted light, microradiography, and scanning electron microscopy showed that mineralized tissue had also formed within the pores of the network. The intimate contact between the individual fibers and the bone within the network was corroborated through microchemical analysis (EDX).

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mentioning

confidence: 99%

Bone tissue formation within a sintered microporous glass‐fiber network implanted in extraction sockets in the rat

Ehrnford¹,

Sundström²,

Wallenius³

1980

European J Oral Sciences

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The effects of pylon shape on bone–pylon interface performance in direct skeletal attachment

Krouskop

Trono

Adamski

1976

J. Biomed. Mater. Res.

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The attachment of a prosthesis directly to the part of the skeleton remaining after an amputation offers many improvements over coupling schemes used in conventional prostheses. However, the stresses induced in the bone by the macrostructure of the attached prosthetic device must first be understood because they are a significant consideration in the design of a successful direct skeletal attachment (DSA) system. This investigation utilizes the finite element method of analysis to structurally model some possible DSA systems. Static stress-response models for an above-the-knee human femoral amputation are formulated to investigate the effect of variations in pylon macrostructure on system performance. The models approximate the initial stages of support following the insertion of a pylon into the medullary cavity of the bone and are also used to assess the bond strengths that must be developed between the bone and pylon for a "no-slip" condition to hold at their interface. The analyses indicate that either a shaped, marrow cavity-fit pylon or four 135 degree wedges with a complementary pylon are favorable geometries for a DSA system. The stress levels caused by these two geometries are on the order of 20% of the axial compressive strength of cortical bone. For each, local stress levels at the bone-biomaterial interface remain the critical parameters for investigation.

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Advancement of Biomimetic Nanoparticles for Targeted Drug Delivery

Sultan

Singh

Rajan

et al. 2022

International Journal of Chemical and Environmental Sciences

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There has been an increasing requirement for more efficient and less iatrogenic therapies for drug delivery, encouraging researches to develop new vectors that ensure targeted delivery of drugs and other therapeutic agents in medicine. Traditional synthetic drug vectors which include polymer and lipid particles are not preferred for clinical applications due to their high cytotoxicity, greater immunogenicity and low cell membrane penetrability. On the other hand, natural particulates ranging from pathogens to mammalian cells are specially optimized for in vivo functions and possess features desirable for drug delivery vectors. Biomimetics involves exploiting biological organisms, cells and molecules or deriving inspiration from them. The Biomimetic Nanoparticles have ushered a new generation of drug carriers, attracting researchers because of their excellent biocompatibility, biodistribution, low chances of recognition and removal by the immune system. Their ability to mimic the bio-structure and function of the biological system makes them reliable drug delivery vectors especially for disease targeting. The advanced biotechnology tools used for engineering synthetic and natural derived nano-systems along with better understanding of biological systems, have enabled researchers to apply these ideas to the delivery of drugs, small interfering RNA, proteins and other therapeutic agents. This review summarizes recent advances in biomimetic nanoparticles used for targeted drug delivery in medicine, obtained by processing synthetic materials using biomimetics. The challenges of biomimetic delivery systems and future directions are also discussed and proposed herein.

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Survey of materials for hard‐tissue prosthesis

Cited by 3 publications

References 11 publications

Bone tissue formation within a sintered microporous glass‐fiber network implanted in extraction sockets in the rat

Bone tissue formation within a sintered microporous glass‐fiber network implanted in extraction sockets in the rat

The effects of pylon shape on bone–pylon interface performance in direct skeletal attachment

Advancement of Biomimetic Nanoparticles for Targeted Drug Delivery

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