Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer

Leonard, Gregory D.; Wright, Marcia; Quinn, Mary; Fioravanti, Suzanne; Harold, Nancy; Schüler, Barbara; Thomas, Rebecca R.; Grem, Jean L.

doi:10.1186/1471-2407-5-116

Cited by 161 publications

(151 citation statements)

References 38 publications

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“…A predetermined protocol to determine the documentation of patients' neurotoxic side effects was developed, influenced by the questionnaire, Oxaliplatin-Associated Neuropathy Questionnaire (OANQ) [26], see Table 1. The protocol was tested on five medical records, and since it captured the neurotoxic side effects, these medical records were included in the study.…”

Section: Sample and Data Collectionmentioning

confidence: 99%

Oxaliplatin Induced Neurotoxicity among Patients with Colorectal Cancer: Documentation in Medical Records—A Pilot Study

Drott¹,

Starkhammar²,

Börjeson³

et al. 2014

OJN

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Patients with colorectal cancer (CRC) can have chemotherapy with oxaliplatin postoperatively. Oxaliplatin can cause acute and chronic neurotoxicity. It is important to be aware of neurotoxic side effects so they can be documented and action taken at an early stage. The study aimed to identify and explore neurotoxic side effects documented in the medical records of patients with colorectal cancer treated with oxaliplatin-based adjuvant chemotherapy. Data in this study were medical records; presenting documentation about patients treated at the University Hospital in the south of Sweden between 2009 and 2010. A summative content analysis approach was used to explore the neurotoxic side effects. Identification and quantification of the content of medical records were carried out by using a study-specific protocol. "Cold sensitivity" and "tingling in the hands" were the most frequently documented neurotoxicity-related terms in the medical records. This identification was followed by interpretation. Three categories were identified in the interpretive part of the study: acute, chronic, and degree of neurotoxicity. The results show the importance of awareness of neurotoxic side effects so that they can be documented and action taken at an early stage. The documentation could be more reliable if patient-reported structured measurements were used, combined with free descriptions in the medical records. Being able to follow the progression of the symptoms during and after treatment would improve patient's safety and also quality of life. The protocol that we developed and used in this review of medical records may be helpful to structure the documentation in the electronic system for documentation of neurotoxicity side effects. Keywords

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Section: Sample and Data Collectionmentioning

confidence: 99%

Oxaliplatin Induced Neurotoxicity among Patients with Colorectal Cancer: Documentation in Medical Records—A Pilot Study

Drott¹,

Starkhammar²,

Börjeson³

et al. 2014

OJN

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“…A Neuropatia Periférica induzida pela quimioterapia é um dos efeitos colaterais mais comuns e indesejáveis no tratamento do câncer colorretal 1,2 , e constitui um fator limitante para o uso de drogas potencialmente eficazes, sendo, muitas vezes, necessária a redução da dose ou a interrupção do tratamento [3][4][5] . A prevalência de neuropatia periférica relacionada ao uso de agentes quimioterápicos vem aumentando devido ao avanço na terapia adjuvante pós-operatória, que proporcionou uma maior sobrevida para os pacientes com esta patologia 1,2 .…”

Section: Introductionunclassified

“…A prevalência de neuropatia periférica relacionada ao uso de agentes quimioterápicos vem aumentando devido ao avanço na terapia adjuvante pós-operatória, que proporcionou uma maior sobrevida para os pacientes com esta patologia 1,2 . Recentemente, a adição de oxaliplatina aos regimes já utilizados como primeira linha de tratamento tem se destacado, tanto pela sua eficácia, quanto pela neurotoxicidade que acarreta, e apresenta, como uma das principais complicações, a neuropatia periférica aguda ou crônica 2,3,[6][7][8][9] .…”

Section: Introductionunclassified

“…Diferentes autores demonstraram a ocorrência de neuropatia periférica sensitiva associada ao uso da oxaliplatina [1][2][3][4][5][6]10 . Essa neuropatia é caracterizada por disestesia, hipoestesia e/ou parestesia distal, e esses sintomas estão correlacionados com a dose administrada, aumentando de intensidade e duração conforme o efeito cumulativo da droga [1][2][3][4][5]7,10 .…”

Section: Introductionunclassified

“…Essa neuropatia é caracterizada por disestesia, hipoestesia e/ou parestesia distal, e esses sintomas estão correlacionados com a dose administrada, aumentando de intensidade e duração conforme o efeito cumulativo da droga [1][2][3][4][5]7,10 . A neuropatia sensitiva é reversível, e responde a reduções de dose ou interrupção do tratamento, porém ela pode persistir durante meses, e, nestes casos, pode afetar a capacidade funcional do paciente e a habilidade de realizar suas atividades de vida diária 1,3,4,11 .…”

Section: Introductionunclassified

See 2 more Smart Citations

Neuropatia Periférica em Pacientes com Câncer Colorretal em Tratamento com Oxaliplatina

Mathias

Machado

Rodrigues

2013

RNC

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Muscle pain in models of chemotherapy‐induced and alcohol‐induced peripheral neuropathy

Álvarez

Ferrari

Levine

2011

Annals of Neurology

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Objective While inflammatory pain is well described in skeletal muscle, neuropathic muscle pain remains to be clarified. We used three well-established rodent models of peripheral neuropathy to evaluate for muscle pain. Methods In rats exposed to either of two neurotoxic cancer chemotherapies, paclitaxel or oxaliplatin, or to alcohol consumption, we assessed the evolution of mechanical hyperalgesia in skeletal muscle and skin, in the same animal. To explore the involvement of protein kinase C epsilon (PKCε), a second messenger implicated in some forms of neuropathic pain, oligodeoxynucleotides (ODN) antisense (AS) or mismatch (MM) for PKCε were administered intrathecally. Results Rats submitted to models of chemotherapy- and alcohol-induced neuropathy developed persistent muscle hyperalgesia, which evolved in parallel in muscle and skin. The administration of PKCε AS, which has been shown to mediate cutaneous hyperalgesia in paclitaxel and ethanol models of neuropathic pain, also inhibited muscle hyperalgesia induced by these agents. Stopping AS-ODN was associated with the reappearance of hyperalgesia at both sites. The AS-ODN to PKCε treatment was devoid of effect in both muscle and skin in the oxaliplatin neuropathy model. Interpretation Our results support the suggestion that neuropathic muscle pain may be a greater clinical problem than generally appreciated.

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Survey of oxaliplatin-associated neurotoxicity using an interview-based questionnaire in patients with metastatic colorectal cancer

Cited by 161 publications

References 38 publications

Oxaliplatin Induced Neurotoxicity among Patients with Colorectal Cancer: Documentation in Medical Records—A Pilot Study

Oxaliplatin Induced Neurotoxicity among Patients with Colorectal Cancer: Documentation in Medical Records—A Pilot Study

Neuropatia Periférica em Pacientes com Câncer Colorretal em Tratamento com Oxaliplatina

Muscle pain in models of chemotherapy‐induced and alcohol‐induced peripheral neuropathy

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