Survey of polynuclear aromatic compounds in oil refining areas

Karlesky, D.; Ramelow, Gerald J.; Ueno, Yoshio; Warner, Isiah M.; Ho, Chu-Ngi

doi:10.1016/0269-7491(87)90156-4

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…Standardized methods are available that are reliable, reproducible, and sensitive enough to separate and quantify PAHs in air (Andersson et al 1983;Fox and Staley 1976;Golden and Sawicki 1978;Harvath 1983;Karlesky et al 1987;Majer et al 1970;Miguel and De Andrade 1989;Naikwadi et al 1987;NIOSH 1984;Oehme 1983;Tomkins et al 1982;Matsumoto and Kashimoto 1985), water (Beniot et al 1979;Desiderie et al 1984;EPA 1986;Furuta and Otsuki 1983;Thomas and.Delfino 1991;Thruston 1978;Xu and Fang 1988), soil and sediment Miller 1987a, 1987b;John and Nickless 1977;Saber et al 1991;Szepesy et al 1981;Tanaka and Saito 1988), and other media, such as food (Hecht et al 1979;Joe et al 1984;Jones et al 1988;Krahn and Malins 1982;Krahn et al 1988;Lawrence and Das 1986;Lawrence and Weber 1984;Poole et al 1987;Toussaint and Walker 1979;Tuominen et al 1988;Van Heddeghem et al 1980;Vassilaros et al 1982;Vreuls et al 1991), cigarette smoke (Risner 1988;), coal tar (Alben 1980…”

Section: Methods For Determining Parent Compounds and Degradation Promentioning

confidence: 99%

The Gulf Oil Spill

2011

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Section: Methods For Determining Parent Compounds and Degradation Promentioning

confidence: 99%

The Gulf Oil Spill

2011

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An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution

Okona-Mensah

Battershill²,

Boobis

et al. 2005

Food and Chemical Toxicology

164

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Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detection

Toriba

Chetiyanukornkul

Kizu

et al. 2003

Analyst

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A high performance liquid chromatographic (HPLC) method for the quantification of 2-hydroxyfluorene (2-OHF) in normal human urine was established using deuterated 2-hydroxyfluorene (2-OHF-d9) as an internal standard with column-switching and fluorescence detection. The 2-OHF-d9 was synthesized by the metabolism of deuterated fluorene with cytochrome P450. The analytes were cleaned up on an ODS pre-column, via column-switching, and separated on an alkylamide-type reversed phase column. The internal standard eluted immediately prior to non-deuterated 2-OHF on the HPLC system and had nearly the same fluorescence characteristics as the non-deuterated 2-OHF. The detection limit was 0.03 nmol l(-1) (S/N = 3) and the calibration range of urine sample was from 0.2 to 50 nmol l(-1). The urine sample treatment involved enzymatic hydrolysis followed by solid phase extraction using a Sep-Pak C18 cartridge. 2-OHF was observed in the form of conjugates such as glucuronide and/or sulfate in human urine, and urinary metabolites were completely hydrolyzed for 2 h with beta-glucuronidase/aryl sulfatase. The proposed method was used to determine urinary 2-OHF in smokers and non-smokers, and showed that the urinary concentrations of 2-OHF in smokers were significantly higher than those in non-smokers (P < 0.01). Thus, the data suggest that urinary 2-OHF might be a sensitive and specific biological marker for the assessment of the exposure to polycyclic aromatic hydrocarbons.

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Survey of polynuclear aromatic compounds in oil refining areas

Cited by 7 publications

References 16 publications

The Gulf Oil Spill

The Gulf Oil Spill

An approach to investigating the importance of high potency polycyclic aromatic hydrocarbons (PAHs) in the induction of lung cancer by air pollution

Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detection

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