Survey of Staphylococcus aureus in a general pediatric population and focus on isolates with three clinically relevant toxin-encoding genes

Filleron, Anne; Beauregard-Birba, Sarah; Mura, Thibault; Aujoulat, Fabien; Michon, Anne Laure; Tran, Tú-Anh; Jeziorski, Éric; Marchandin, Hélène

doi:10.1007/s12519-018-0118-x

Cited by 5 publications

(7 citation statements)

References 46 publications

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“…Interestingly, 77.8% of MRSA isolates carried at least one toxin‐encoding gene. Luk‐PV was twice as prevalent in MRSA compared to MSSA . This pattern suggests that MRSA is more likely to cause toxin‐induced inflammation compared to MSSA.…”

Section: Virulencementioning

confidence: 92%

“…Virulence of S. aureus is associated with secretion of multiple toxins controlled by locus agr (accessory gene regulator). Among other virulence factors, α‐hemolysin, toxic shock syndrome toxin (TSST‐1), SEA (Staphylococcal enterotoxin A), and Panton‐Valentine leukocidin (PVL) are associated with severe infections including bacteremia, osteomyelitis, and necrotic pneumonia . Yet, septic and necrotic S. aureus infections are rarely seen in CF.…”

Section: Virulencementioning

confidence: 99%

“…In a French study conducted between 2008 and 2010, Filleron et al surveyed S. aureus isolates obtained from pediatric inpatients and outpatients. They showed that tst , sea , and luk‐PV were identified in 14.3%, 9.5%, and 5.8% of the isolates, respectively . Interestingly, 77.8% of MRSA isolates carried at least one toxin‐encoding gene.…”

Section: Virulencementioning

confidence: 99%

“…They showed that tst, sea, and luk-PV were identified in 14.3%, 9.5%, and 5.8% of the isolates, respectively. 59 Interestingly, 77.8% of MRSA isolates carried at least one toxin-encoding gene. Luk-PV was twice as prevalent in MRSA compared to MSSA.…”

Section: Epidemiologymentioning

confidence: 99%

“…Luk-PV was twice as prevalent in MRSA compared to MSSA. 59 This pattern suggests that MRSA is more likely to cause toxin-induced inflammation compared to MSSA. However, it is unclear if this conclusion can be extrapolated to the CF population since Filleron et al excluded patients S66 | with CF from their study.…”

Section: Epidemiologymentioning

confidence: 99%

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Biology and management of methicillin resistantStaphylococcus aureusin cystic fibrosis

Akil

Muhlebach

2018

Pediatric Pulmonology

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Staphylococcus aureus is one of the earliest bacteria isolated from the respiratory tract in people with cystic fibrosis (CF). Its methicillin resistant form, MRSA, has gained attention due to the rapid increase in the last decades and worse outcomes with chronic infection. In the United States, prevalence of MRSA in CF is around 27%, but is much lower (3-18%) in most other countries. Methicillin is typically genetically encoded by the mecA gene, which encodes for an alternative penicillin binding protein (PRBa). This PRBa has low affinity to β-lactams, thereby enabling growth of S. aureus in the presence of penicillinase resistant penicillins and most other β-lactams. Non-mecA positive strains of MRSA, so-called borderline resistant (BORSA) have also been described. In addition to production of toxins, the virulence of S. aureus is conferred by its adaptability allowing persistence in face of antibiotic therapies and host defense. These adaptive growth mechanisms include small colony variants, biofilms, and growth under anaerobic conditions. Several reports have described successful eradication of MRSA, yet only two randomized trials of eradication during early infection have been conducted. A list of MRSA specific antibiotics with dosing relevant to CF patients is presented here. Many of these require special dosing in people with CF. Novel antibiotics are in trials for skin and soft tissue infections and it is unclear if and when those might be available for lung infections. Thus the best strategies for MRSA would be primary prevention.

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Section: Virulencementioning

confidence: 92%

Section: Virulencementioning

confidence: 99%

Section: Virulencementioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

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