Survey on association between Mycoplasma hominis endocervical infection and spontaneous abortion using Polymerase Chain Reaction

Abstract

Background:Mycoplasma infections are suggested as etiology of adverse pregnancy outcomes. Objective:The aim of this study was to evaluate the association of Mycoplasma hominis (M. hominis) infection and spontaneous abortion among pregnant women.Materials and Methods:In this case-control study that was conducted from August 2012 to January 2013, totally, 109 women were included with spontaneous abortion with gestational ages of 10-20 weeks (Cases), and 109 women with normal pregnancy with gestational ages between 20-37 weeks (Controls) in Sanandaj, Iran. Using specific primers and extracted DNA from endocervical swabs, a PCR test was conducted for detection of M. hominis infection in women. For comparison of qualitative and quantitative variables, independent Fisher tests were used and p<0.05 was considered significant.Results:The total frequency of M. hominis infection was 6 (2.75%) in women. The frequency of M. hominis infection was 2 (1.83%) in the case group (spontaneous abortion) and 4 (3.66%) in the control group, respectively. In both case and control groups, no association was seen between M.hominis infection and spontaneous abortion (OR=0. 49, CI 95%: 0.08-2.73, p=0. 683). Conclusion:M. hominis was positive in the genital tract of some pregnant women, but it was not associated with spontaneous abortion. However, to prevent adverse pregnancy outcomes in women, foetus and neonate, routine screening and treatment for the genital Mycoplasma is recommended.

Association of spontaneous abortion and Ureaplasma parvum detected in placental tissue

“…However, a direct relationship with the development of abortion was not observed. In other studies, the results were also similar [24, 28]. These microorganisms are often found in the genital tract of pregnant women, where they can invade the placenta and contribute to the development of abortion.…”

Is there an association between recurrent spontaneous abortion and mycoplasma infection?

“…The study reported that M. hominis and U. urealyticum were present in 5% and 3% of the chorionic villi samples, which was much lower than that reported in the present study [17]. Farhadifar et al [18] and Ramazanzadeh et al [19] reported much lower rate of M. hominis. These studies evaluated the association between M. hominis and spontaneous abortion in 109 women.…”

Blood Culture-Negative Infective Endocarditis by Mycoplasma hominis: Case Report and Literature Review

“…They are beta-lactam-resistant due to the absence of a cell wall, and their high nutritional demand makes them difficult to culture [1,2], although this problem has recently been solved by applying molecular techniques. They are often found as colonizers of mucosae, mainly respiratory and genitourinary [3,4]. Mycoplasma hominis was the first of various human pathogen species to be isolated.…”