ASP (alkaline/surfactant/polymer) flooding oilfield wastewater, which is commonly produced in the oil extraction process, contains high organic content, and the waste crude oil, water resources and sewage need to be treated prior to re-injection. In this study, pre-treated ASP flooding oil field water produced in Daqing, China, was treated by a PTFE microfiltration membrane and the removal efficiency of main pollutants in oil field-produced water was studied. The contents of oil and suspended solids (SS) in the permeate obtained with the membranes were 1.15 mg/L and 1.61 mg/L, respectively, which met the re-injected water quality standards in China. Microscopic analysis of fouling showed that the membrane pollutants were mainly composed of petroleum organic pollutants, and a small amount of SiO2, CaCO3, MgCO3 and other inorganic pollutants was observed. Accordingly the operating conditions of the operating flux, back-washing cycle, back-washing flux and gas-washing flux were investigated to decrease the membrane fouling.