The commonest medication to treat moderate to severe pain and fever in adults and children is paracetamol and it has been observed that there has been a rapid increase in the intake of
paracetamol-650 since the COVID-19 pandemic and it has continued to date. This analgesic and
antipyretic medication showed an increase of 150% in its consumption during the pandemic, simultaneously escalating its self-medication. Concerns have been expressed about the indirect advertising
of prescription medications, their illogical use, and improper self-medication, which has resulted in
overdose and certain serious side effects. Chronic pain and pyrexia are the most common symptoms
witnessed during the COVID-19 pandemic. The intake of paracetamol-650 has also been increased
as a prophylactic measure due to the widespread fear generated during COVID-19. The usage of
paracetamol has been shifted from 500 mg to 650 mg for mild and moderate pain and fever during
and after the end of the pandemic. This raises concerns about the misuse of paracetamol-650mg
which may cause damage to the liver, stomach, and kidney chronically. So, this review article aims
to generate awareness among the public and physicians about the rationale of paracetamol as an analgesic and antipyretic.