Survie à deux ans des cirrhotiques suivis à Pointe-Noire de 2005 à 2014

Bossali, F.; Gassaye, Déby; Atipo-Ibara, B. I.; Koumou-Okandzé, L.; Kamba, S. Katendé; Loemba, E.; Ibara, J. R.

doi:10.1007/s12157-015-0585-9

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Republic of Congo is classified as having high endemicity of HBV [ 18 ] with a prevalence of Hepatitis B surface antigen (HBsAg) ranges from 6.5 % to 11.4 % [ 19 – 22 ]. The average length of survival is low due to stage of gravity and to late hospitalization of patients [ 23 ]. This virus is considered as the most common cause of cirrhosis (63 %) and HCC (73.5 %) in Pointe Noire and Brazzaville [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Angounda

Ngouloubi

Dzia

et al. 2016

Infect Agents Cancer

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BackgroundChronic Hepatitis B infection is a major health problem in Republic of Congo therefore molecular analysis of HBV strains is important to detect the patients at high risk of disease progression.MethodsSerum samples were obtained from 111 chronic HBV patients in Pointe Noire. HBsAg, HBeAg and HBeAb were detected. A fragment of the preS1 region of HBV was amplified and sequenced to determine genotypes, subgenotypes and to identify mutations.ResultsOf the 111 samples analyzed, 35 patients were asymptomatic carriers (ASC), 24 with a chronic active hepatitis (CAH), 33 with liver cirrhosis (LC) and 19 have a hepatocellular carcinoma (HCC). The mean age were 45 ± 13 year, 88 (79.3 %) were male and 23 (20.7 %) female. The prevalence of HBeAg was 15.3 % and 73 % of subjects were anti-HBe positive. The mean serum level of alanine aminotransferase transaminase (ALT) and aspartate transaminase (AST) was 25.1 ± 9 IU/L and 28.6 ± 10 IU/L respectively. Eighty two samples out of 111 (73.9 %) were genotyped by the analyzing of the S region of HBV, 58 (70.7 %) cases belonged to HBV genotype E and 24 (29.3 %) were genotype A with three subgenotypes; A3 (66.7 %), A4 (20.8 %) and A6 (12.5 %). Prevalence of genotype A was relatively high in CAH (33.3 %) and HCC (31.6 %) patients in comparison with other groups. The most prevalent amino acids substitutions were R38K found in 14 (17.1 %) sequences, following by H44L in 11 (13.4 %), K13E in 8 (9.8 %), N29K in 8 (9.8 %), A35E in 8 (9.8 %), V80I in 7 (8.5 %) and in 6 (7.3 %) sequences for S90T. Different substitutions located in the hepatocyte binding site were higher among patients with LC and HCC (p < 0.05).ConclusionsThis study have shown that HBV genotype E and A were the most frequent strains circulating in Republic of Congo patients. HBV pres1 substitutions found in this study were associated with severe clinical forms of liver diseases. This data have shown the importance of implementing an effective program to fight HBV infection.

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Section: Introductionmentioning

confidence: 99%

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Angounda

Ngouloubi

Dzia

et al. 2016

Infect Agents Cancer

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“…The hospital prevalence of cirrhosis varies widely by country and by specialization. In Hepato-Gastroenterology departments, it is 17.6% in Uganda [6], 22.6% in Benin [7] and 15% in France [8]; in Internal Medicine department, it is 3.2% in Congo [9]. Our patients have an average age of 44.5 years and those aged 30 to 39 represent the majority (Figure 1).…”

Section: Figure 1: Distribution Of Patients By Agementioning

confidence: 90%

“…The age of cirrhotic patients is young in southern countries in relation to the youth of the population, but also because of the endemicity and the early onset of chronic viral infections B and C. Men seem more exposed to the risk factors explaining the male predominance noted in the majority of studies [1][2][3][4][5][6][7][8][9]13,14]. As in the other African series [5][6][7][8][9][10][11][12], the clinical and biological manifestations as well as the prognostic stages reveal severe stages because of the delay of the diagnosis (Tables 1 & 2). In Wang's patients in China [14], the mean MELD score was 15.3 while 84.3% of our patients had a score greater than 15 and 32.3% had a score above 30.…”

Section: Figure 1: Distribution Of Patients By Agementioning

confidence: 99%

Clinical, Paraclinical and Etiological Aspects of Cirrhosis in a Department of Internal Medicine in Senegal

Dia

2019

ARGH

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Évaluation de la performance des services d’hépatogastroentérologie pour la prise en charge des cirrhotiques au Congo-Brazzaville en 2014

Bossali¹,

Gassaye

Atipo-Ibara

et al. 2015

J Afr Hepato Gastroenterol

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Survie à deux ans des cirrhotiques suivis à Pointe-Noire de 2005 à 2014

Cited by 5 publications

References 12 publications

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Molecular characterization of hepatitis B virus among chronic hepatitis B patients from Pointe Noire, Republic of Congo

Clinical, Paraclinical and Etiological Aspects of Cirrhosis in a Department of Internal Medicine in Senegal

Évaluation de la performance des services d’hépatogastroentérologie pour la prise en charge des cirrhotiques au Congo-Brazzaville en 2014

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