Survival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity

Levy, Becca R.; Bavishi, Avni

doi:10.1093/geronb/gbw035

Cited by 42 publications

(50 citation statements)

References 23 publications

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“…Though researchers have spent decades describing ageing phenotypes, it is rare that the longitudinal trends in several prespecified assessments are presented collectively using the same cohort, which may allow us to better understand the reciprocal temporal relationship of change and assess the stability of measurement among community dwelling older adults. For example, CRP has been proposed as an ageing phenotype . Even though we did not observe an obvious overall trend of increasing CRP, we did observe statistically significant increasing CRP using the log‐transformed CRP for the analysis (Table , Fig.…”

Section: Discussionmentioning

confidence: 67%

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

et al. 2020

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Over the past three decades, considerable effort has been dedicated to quantifying the pace of ageing yet identifying the most essential metrics of ageing remains challenging due to lack of comprehensive measurements and heterogeneity of the ageing processes. Most of the previously proposed metrics of ageing have been emerged from cross‐sectional associations with chronological age and predictive accuracy of mortality, thus lacking a conceptual model of functional or phenotypic domains. Further, such models may be biased by selective attrition and are unable to address underlying biological constructs contributing to functional markers of age‐related decline. Using longitudinal data from the Baltimore Longitudinal Study of Aging (BLSA), we propose a conceptual framework to identify metrics of ageing that may capture the hierarchical and temporal relationships between functional ageing, phenotypic ageing and biological ageing based on four hypothesized domains: body composition, energy regulation, homeostatic mechanisms and neurodegeneration/neuroplasticity. We explored the longitudinal trajectories of key variables within these phenotypes using linear mixed‐effects models and more than 10 years of data. Understanding the longitudinal trajectories across these domains in the BLSA provides a reference for researchers, informs future refinement of the phenotypic ageing framework and establishes a solid foundation for future models of biological ageing.

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Section: Discussionmentioning

confidence: 67%

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

et al. 2020

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“…In four of these domains, all studies showed evidence of ageism. To illustrate, ageism consistently impacted the ultimate endpoint-reduced longevity: all 10 studies found ageism predicted a shorter lifespan in Australia, China, Germany, and the United States [56][57][58][59][60][61][62][63][64][65]. In one study, using nationally representative data in China, researchers found that older persons with more negative self-perceptions of aging had significantly reduced longevity [62].…”

Section: Impact Of Ageism On Health Of Older Persons: Individual Levelmentioning

confidence: 99%

“…The physiological pathway linking ageism to adverse health has only been examined by two studies so far. In one, a recent population-based study showed that the C-reactive protein, a stress biomarker of inflammation, partially mediated the longitudinal relationship between self-perceptions of aging and longevity [65].…”

Section: Mediation Of the Association Between Ageism And Healthmentioning

confidence: 99%

Global reach of ageism on older persons’ health: A systematic review

et al. 2020

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Objective Although there is anecdotal evidence of ageism occurring at both the structural level (in which societal institutions reinforce systematic bias against older persons) and individual level (in which older persons take in the negative views of aging of their culture), previous systematic reviews have not examined how both levels simultaneously influence health. Thus, the impact of ageism may be underestimated. We hypothesized that a comprehensive systematic review would reveal that these ageism levels adversely impact the health of older persons across geography, health outcomes, and time. Method A literature search was performed using 14 databases with no restrictions on region, language, and publication type. The systematic search yielded 13,691 papers for screening, 638 for full review, and 422 studies for analyses. Sensitivity analyses that adjusted for sample size and study quality were conducted using standardized tools. The study protocol is registered (PROSPERO CRD42018090857). Results Ageism led to significantly worse health outcomes in 95.5% of the studies and 74.0% of the 1,159 ageism-health associations examined. The studies reported ageism effects in all 45 countries, 11 health domains, and 25 years studied, with the prevalence of significant findings increasing over time (p < .0001). A greater prevalence of significant ageism-health findings was found in less-developed countries than more-developed countries (p = .0002). Older persons who were less educated were particularly likely to experience adverse health effects of ageism. Evidence of ageism was found across the age, sex, and race/ethnicity of the targeters (i.e., persons perpetrating ageism).

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“…It appears that SPA predict later health more strongly than health predicts later SPA, creating a self‐fulfilling prophecy that is at least partially explained by physical, behavioral, and psychological pathways . Older adults with negative SPA are more likely to have greater inflammation 4 years later, which mediates survival . They engage in fewer health‐promoting behaviors, adaptive coping strategies during a serious health event, and active and social leisure pursuits .…”

Section: Introductionmentioning

confidence: 99%

“…3 Older adults with negative SPA are more likely to have greater inflammation 4 years later, which mediates survival. 9 They engage in fewer health-promoting behaviors, 10,11 adaptive coping strategies during a serious health event, 8 and active and social leisure pursuits. 12 They also experience greater declines in cognitive functioning, 13 particularly if they are frail.…”

Section: Introductionmentioning

confidence: 99%

Self‐perceptions of aging mediate the longitudinal relationship of hopelessness and depressive symptoms

Gum

Ayalon

2017

Int J Geriat Psychiatry

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As hypothesized, change in self-perceptions of aging partially mediated the relationship of hopelessness with depressive symptoms 6 years later. Findings are consistent with a conceptualization of hopelessness as broad negative expectations about the future that may contribute to negative self-perceptions of aging and subsequent changes in depressive symptoms. Reducing hopelessness, increasing hope, and improving self-perceptions of aging have potential to reduce and prevent depressive symptoms for older adults. Future research should examine the mechanisms of these interrelationships and other aging outcomes.

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Survival Advantage Mechanism: Inflammation as a Mediator of Positive Self-Perceptions of Aging on Longevity

Abstract: It was found that lower CRP partially mediates the relationship between positive SPA and longer survival. Hence, this study presents a novel pathway to explain the process by which positive SPA extend longevity.

Cited by 42 publications

References 23 publications

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging

Global reach of ageism on older persons’ health: A systematic review

Self‐perceptions of aging mediate the longitudinal relationship of hopelessness and depressive symptoms

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