Survival after biochemical failure in prostate cancer treated with radiotherapy: Spanish Registry of Prostate Cancer (RECAP) database outcomes

Segundo, Carmen González‐San; Jové, Josep; Zapatero, A.; Pastor-Peidro, J; Vázquez, M L; Casaña, M.; Mengual, J.; Gómez-Caamaño, Antonio; Gómez-Iturriaga, A.; Vallejo, Carmen; Henrı́quez, I.; Muñoz-García, Julia L.; Clemente, Joey; Porras, M.; Collado, E.; Ossola, G.; Villafranca, E.; Cabeza, M.A.; López-Torrecilla, J.

doi:10.1007/s12094-018-02021-7

Cited by 8 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, within 10 years, 20%–40% of post-RP [3] and 30%–50% of post-RT [4] patients will experience biochemical recurrence. On average, this precedes the appearance by eight years after RP of clinical metastases [5,6] that are the major cause of complications and death [7]. For these patients, a successful therapy is still unavailable, creating the need for additional prognostic markers and for molecular targeted therapeutical strategies.…”

Section: Introductionmentioning

confidence: 99%

H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer

Bacci

Aiello

Ripoli

et al. 2019

IJMS

View full text Add to dashboard Cite

Estrogen and hypoxia promote an aggressive phenotype in prostate cancer (PCa), driving transcription of progression-associated genes. Here, we molecularly dissect the contribution of long non-coding RNA H19 to PCa metastatic potential under combined stimuli, a topic largely uncovered. The effects of estrogen and hypoxia on H19 and cell adhesion molecules’ expression were investigated in PCa cells and PCa-derived organotypic slice cultures (OSCs) by qPCR and Western blot. The molecular mechanism was addressed by chromatin immunoprecipitations, overexpression, and silencing assays. PCa cells’ metastatic potential was analyzed by in vitro cell-cell adhesion, motility test, and trans-well invasion assay. We found that combined treatment caused a significant H19 down-regulation as compared with hypoxia. In turn, H19 acts as a transcriptional repressor of cell adhesion molecules, as revealed by up-regulation of both β3 and β4 integrins and E-cadherin upon H19 silencing or combined treatment. Importantly, H19 down-regulation and β integrins induction were also observed in treated OSCs. Combined treatment increased both cell motility and invasion of PCa cells. Lastly, reduction of β integrins and invasion was achieved through epigenetic modulation of H19-dependent transcription. Our study revealed that estrogen and hypoxia transcriptionally regulate, via H19, cell adhesion molecules redirecting metastatic dissemination from EMT to a β integrin-mediated invasion.

show abstract

Section: Introductionmentioning

confidence: 99%

H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer

Bacci

Aiello

Ripoli

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…While multiple salvage treatment options are available, a significant number of patients in this context are often offered lifelong androgen deprivation therapy, which is purely palliative in nature and comes with substantial morbidity [18] , [19] . Data from the Spanish Registry of Prostate Cancer (RECAP) revealed in 2016 that over 70 % of patients who experienced biochemical failure (BF) following radiotherapy received ADT, while only 6 % received salvage BT [20] .…”

Section: Discussionmentioning

confidence: 99%

Salvage low-dose-rate brachytherapy for locally recurrent prostate cancer after definitive irradiation

Meraouna,

Blanchard,

Losa

et al. 2024

Clinical and Translational Radiation Oncology

View full text Add to dashboard Cite

“…Knowledge of the risk of recurrence can assist stratification of cancer management pathways (personalized medicine). BF is often used as a surrogate for treatment failure due to the long natural progression of disease, but studies have shown that BF is not an accurate predictor of survival outcome 155,156 . Imaging biomarkers derived from qMRI may potentially provide a method for monitoring longitudinal post‐RT response for early and accurate prediction of recurrent cancer and improve clinical outcomes by offering localized treatments prior to development of metastases.…”

Section: Imaging and Prediction Of Recurrent Pcamentioning

confidence: 99%

Artificial intelligence and imaging biomarkers for prostate radiation therapy during and after treatment

et al. 2021

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) is increasingly used in the management of prostate cancer (PCa). Quantitative MRI (qMRI) parameters, derived from multi‐parametric MRI, provide indirect measures of tumour characteristics such as cellularity, angiogenesis and hypoxia. Using Artificial Intelligence (AI), relevant information and patterns can be efficiently identified in these complex data to develop quantitative imaging biomarkers (QIBs) of tumour function and biology. Such QIBs have already demonstrated potential in the diagnosis and staging of PCa. In this review, we explore the role of these QIBs in monitoring treatment response during and after PCa radiotherapy (RT). Recurrence of PCa after RT is not uncommon, and early detection prior to development of metastases provides an opportunity for salvage treatments with curative intent. However, the current method of monitoring treatment response using prostate‐specific antigen levels lacks specificity. QIBs, derived from qMRI and developed using AI techniques, can be used to monitor biological changes post‐RT providing the potential for accurate and early diagnosis of recurrent disease.

show abstract

Survival after biochemical failure in prostate cancer treated with radiotherapy: Spanish Registry of Prostate Cancer (RECAP) database outcomes

Cited by 8 publications

References 41 publications

H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer

H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer

Salvage low-dose-rate brachytherapy for locally recurrent prostate cancer after definitive irradiation

Artificial intelligence and imaging biomarkers for prostate radiation therapy during and after treatment

Contact Info

Product

Resources

About