Survival after massive "ecstasy" (MDMA) ingestion

Regenthal, Ralf; Krüger, Monika; Rudolph, Karin; Trauer, H.; Preiss, R

doi:10.1007/s001340050920

Cited by 16 publications

(9 citation statements)

References 7 publications

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“…Included in the metabolites in the COMT pathway of degradation is a major metabolite, 4-hydroxy-3-methoxymethamphetamine (HMMA). HMMA has been documented as a more potent inducer of ADH secretion (13)(14)(15)(16)(17). As discussed next, the effects of this metabolite on the pituitary could explain the variable incidence of hyponatremia seen in ecstasy users.…”

Section: Pharmacologymentioning

confidence: 94%

The Agony of Ecstasy

Campbell

Rosner

2008

Clinical Journal of the American Society of Nephrology

109

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Ecstasy (MDMA, 3,4-methylenedioxymethamphetamine) is commonly used by college-aged individuals. Ecstasy leads to feelings of euphoria, emotional empathy, and increased energy. These effects come at a significant risk for complications. Ecstasy has been associated with acute kidney injury that is most commonly secondary to nontraumatic rhabdomyolysis but also has been reported in the setting of drug-induced liver failure and drug-induced vasculitis. More common, ecstasy has led to serious hyponatremia and hyponatremia-associated deaths. Hyponatremia in these cases is due to a "perfect storm" of ecstasy-induced effects on water balance. Ecstasy leads to secretion of arginine vasopressin as well as polydipsia as a result of its effects on the serotonergic nervous pathways. Compounding these effects are the ready availability of fluids and the recommendation to drink copiously at rave parties where ecstasy is used. The effects of ecstasy on the kidney as well as therapeutic measures for the treatment of ecstasy-induced hyponatremia are presented.

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Section: Pharmacologymentioning

confidence: 94%

The Agony of Ecstasy

Campbell

Rosner

2008

Clinical Journal of the American Society of Nephrology

109

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“…Other case reports have highlighted the poor doseresponse relationship of MDMA, with fatalities at blood levels of 0.11 mg.l )1 and minimally symptomatic patients with serum levels of 4.3 and 7.72 mg.l )1 [9][10][11][12]. Our patient had life-threatening multi-organ failure with a peak MDMA level of only 0.147 mg.l )1…”

Section: Discussionmentioning

confidence: 58%

Ecstacy‐induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene

et al. 2012

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“…Therefore, the MDMA tablets in our case were pure. There could be a relationship between serum concentrations and toxic effects of MDMA, but a case report of survival after massive MDMA intake shows that high concentrations do not necessarily indicate life-threatening complications (5,6).…”

Section: Discussionmentioning

confidence: 95%