Survival After Minimally Invasive Surgery in Older Women With Endometrial Carcinoma

Cardenas-Goicoechea, Joel; Wang, Yu; LEE, JI-HYUN; Shoraka, Massoud; Carbajal-Mamani, Semiramis; Fishman, David A.; Riner, Andrea N.; Treviño, José G.

doi:10.21873/anticanres.15459

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to the National Comprehensive Cancer Network (NCCN) guidelines, the older age, myometrial invasion (MI) along with lymphovascular space invasion (LVSI) have been believed to deteriorate the prognosis in early-stage EC [ 21 , 22 ]. One recent retrospective analysis of the U.S. National Cancer Data Base has revealed that MIS could improve OS in all elder EC women with an increased survival rate by 12% (HR = 0.86; 95%CI = 0.80–0.92; p < 0.001), leaving its impact on PFS unknown [ 23 ]. However, we fail to detect the superiority of MIS on PFS in stage IA elder EC patients in our study, indicating patients’ age would not influence the impact of surgical approach on PFS.…”

Section: Discussionmentioning

confidence: 99%

Impact of surgical approach on progress of disease by type of histology in stage IA endometrial cancer: a matched-pair analysis

Miao,

Zhang,

Jiang

et al. 2024

BMC Surg

View full text Add to dashboard Cite

Background To compare the impact of surgical approach on progression free survival (PFS) stratified by histologic type in women diagnosed with stage IA endometrial cancer. Methods Myometrial invasion is classified into no myometrial invasion, <50% and ≥50%, with only no myometrial invasion and <50% are included in stage IA patients. A retrospective study is designed by collecting data from women diagnosed as stage IA endometrial cancer from January 2010 to December 2019 in a tertiary hospital. A propensity score is conducted for 1:1 matching in the low-risk histologic patients. Progression free survival and disease-specific survival data are evaluated by the Kaplan–Meier method and compared by the log-rank test in both the whole population and the matched-pair groups. A sub-group analysis is performed to figure out risk factors associated with the effect of surgical approach on PFS and disease-specific survival (DSS). Results 534 (84.49%) low-risk histologic endometrial cancer women, with 389 (72.85%) operated by minimally invasive surgery and 145 (27.15%) by open approach, and 98 (15.51%) high-risk histology, with 71 (72.45%) by laparoscopy and 27 (27.55%) by open surgery, are included. Compared to open surgery, laparoscopy results in lower progression free survival in low-risk patients before and after matching (p = 0.039 and p = 0.033, respectively), but shows no difference in high-risk patients (p = 0.519). Myometrial invasion is associated with lower progression free survival in laparoscopy in low-risk histology (p = 0.027). Conclusion Surgical approaches influence progression free survival in stage IA low-risk histologic diseases, especially in those with myometrial invasion, but not in high-risk histologic endometrial cancer.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of surgical approach on progress of disease by type of histology in stage IA endometrial cancer: a matched-pair analysis

Miao,

Zhang,

Jiang

et al. 2024

BMC Surg

View full text Add to dashboard Cite

show abstract

The treatment of special types of endometrial cancer

Zhang

et al. 2022

Asian Journal of Surgery

View full text Add to dashboard Cite

The application value of the Da Vinci robot-assisted surgery in lymphadenectomy for endometrial cancer: a retrospective cohort study

Duan

Yang

Peng

et al. 2022

Preprint

View full text Add to dashboard Cite

Purpose To investigate whether there is any difference in the safety, feasibility and intraoperative lymph node clearance of the Da Vinci robot-assisted surgery in endometrial cancer lymph node dissection compared to conventional laparoscopic surgery. Methods A retrospective analysis was made on the clinical data of 83 patients with endometrial cancer enrolled in the Affiliated Hospital of Jining Medical University from January 2018 to March 2022. 41 patients received Da Vinci robot-assisted surgery (RAS group) and 42 received conventional laparoscopic surgery (CLS group). To collect and compare the general condition, operation time, intraoperative bleeding, presence of intraoperative injury, postoperative exhaustion time, application of antibiotics, duration of pelvic drainage tube retention, duration of indwelling catheter, whether postoperative pain medication was applied, whether postoperative abdominal distension was present, number of intraoperative lymph nodes cleared and positive, and LNR between the two groups. Results There was a statistically significant difference (P < 0.05) between the two groups in terms of operative time. There was no statistically significant difference (P > 0.05) in terms of intraoperative bleeding, postoperative time to exhaustion, time to apply antibiotics, time to leave a pelvic drain in place, time to leave a catheter in place, length of hospital stay, whether pain medication was applied postoperatively, and whether there was postoperative abdominal distension. When comparing the number of lymph nodes cleared intraoperatively, the number of positives and LNR between the two groups, the differences were statistically significant (P < 0.05). When the surgical approach, number of intraoperatively cleared lymph nodes, maximum diameter of the mass, tissue grading, type of postoperative pathology, myxomatous infiltration, cervical interstitial involvement and vascular infiltration were compared with the number of positive intraoperative cleared lymph nodes and LNR in each of the 83 patients in a univariate analysis, the differences between the number of intraoperative cleared lymph nodes, maximum diameter of the mass, tissue grading, type of postoperative pathology and cervical interstitial involvement were The differences were not statistically significant (P > 0.05), while the differences were statistically significant (P < 0.05) when comparing the surgical approach, tumour myxomatous infiltration and choroidal infiltration. The number of positive intraoperative lymph node dissection (P = 0.0498) and LNR (P = 0.0455) were compared between the two groups after multiple regression analysis of tumour myofibrotic infiltration and choroidal infiltration, and the differences were statistically significant (P < 0.05). Conclusion This may be related to the 360o wrist rotation of the instrument arm of the Da Vinci robot-assisted surgery, which allows for the smooth removal of deep pelvic lymph nodes with clear exposure, thus allowing more lymph nodes to be cleared, but the relationship remains to be investigated.

show abstract

Survival After Minimally Invasive Surgery in Older Women With Endometrial Carcinoma

Cited by 3 publications

References 0 publications

Impact of surgical approach on progress of disease by type of histology in stage IA endometrial cancer: a matched-pair analysis

Impact of surgical approach on progress of disease by type of histology in stage IA endometrial cancer: a matched-pair analysis

The treatment of special types of endometrial cancer

The application value of the Da Vinci robot-assisted surgery in lymphadenectomy for endometrial cancer: a retrospective cohort study

Contact Info

Product

Resources

About