Survival after severe methemoglobinemia secondary to sodium nitrate ingestion

Cruz, Maricel Dela; Glick, Joshua; Merker, Seth H.; Vearrier, David

doi:10.1080/24734306.2018.1467532

Cited by 21 publications

(11 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[3] Methemoglobin levels >70% are lethal, but survival has been reported in more than 90% of cases. [ 5 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

“…The number of cases of sodium nitrite intoxication due to a suicidal attempt has increased. [ 4 , 5 ] A recent study conducted in Korea reported 14 autopsy cases from sodium nitrite poisoning from 2013 to 2019. Until 2017, there has been 1 autopsy every year, but it increased to 8 cases in 2018.…”

Section: Discussionmentioning

confidence: 99%

“…[3] Methemoglobin levels >70% are lethal, but survival has been reported in more than 90% of cases. [5,7] Methylene blue is the first-line antidote for severe methemoglobinemia, and the standard dose is 1 to 2 mg/kg intravenously over 5 minutes. [1] The methemoglobin level decreases significantly within 1 to 2 hours after a single dose.…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] However, recent studies have reported intentional intake in suicide attempts. [4,5] Regardless of the etiology, the severity of methemoglobinemia depends on the methemoglobin concentration. A methemoglobin concentration above 10% causes cyanosis.…”

Section: Introductionmentioning

confidence: 99%

“…Most cases of clinically significant sodium nitrite intoxication were accidental, such as inadvertent intake [2,3] . However, recent studies have reported intentional intake in suicide attempts [4,5] …”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Two cases of fatal methemoglobinemia caused by self-poisoning with sodium nitrite

Mun¹,

Park²,

Lee³

et al. 2022

Medicine

View full text Add to dashboard Cite

Rationale:Sodium nitrite intoxication reportedly causes severe methemoglobinemia. Recent studies reported that most clinically significant cases resulted from intentional exposure in suicidal attempts. We describe 2 cases of severe methemoglobinemia secondary to intentional sodium nitrite intoxication in suicidal attempts.Patients concerns:A 26-year-old man and 20-year-old woman attempted suicide by taking sodium nitrite, and were brought to the emergency department.Diagnosis:The male patient collapsed at the scene. He ingested approximately 18 g of sodium nitrate, and his methemoglobin level was 90.3%. The female patient was conscious, but was cyanotic. She ingested approximately 12.5 g of sodium nitrite, and her methemoglobin level was 54.6%.Interventions:The male patient received advanced cardiac life support in the emergency department. Methylene blue was immediately administered for the female patient.Outcomes:The male patient died despite aggressive resuscitation. The female patient's cyanosis resolved, and her methemoglobin level decreased to 1.2% 3 hours later.Lessons:The immediate administration of methylene blue in severe methemoglobinemia patients prevented fatal consequences. The public should be informed about the accessibility and toxicity of sodium nitrite.

show abstract

“…[3] Methemoglobin levels >70% are lethal, but survival has been reported in more than 90% of cases. [ 5 , 7 ]…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%