Survival after surgical treatment of cancer of the rectum

Hohenberger, Werner; Bittorf, B.; Papadopoulos, Thomas; Merkel, Susanne

doi:10.1007/s00423-004-0497-4

Cited by 17 publications

(9 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar to our study, more recent studies confirmed the significant impact of s-CEA on patient outcome in multivariate analyses (8,(24)(25)(26)(27)(28)(29). Our group was too small for effective stratification of the s-CEA importance in Dukes' stages.…”

Section: Discussionsupporting

confidence: 84%

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

Szynglarewicz¹,

Matkowski²,

Forgacz³

et al. 2007

Oncol Rep

View full text Add to dashboard Cite

Abstract. The aim of the study was to estimate the long-term results and the prognostic value of clinical and pathological factors following R0 anterior resection with total mesorectal excision (TME). Ninety-eight consecutive patients with histologically confirmed rectal cancer were studied prospectively with five-year follow-up. Survival was calculated using the Kaplan-Meier method and differences between curves were tested by the log-rank test. Multivariate analysis was performed using the Cox regression model. Recurrence-free survival (RFS) was 63.6%. Mean time of recurrence was 13.8 months (range 3-38). Local recurrence rate was 7.8% with the mean time of 12.7 months (range 3-25). In univariate analysis Dukes' stage (RFS for stage: A=93.2%; B=53.8%; C=26.3%) and preoperative CEA serum level (s-CEA) (for s-CEA ≤5 ng/ml RFS=93.8%; for s-CEA >5 ng/ml RFS = 5.9%) significantly influenced survival (P<0.005 and P<0.00001). These parameters were also found to be independent prognostic factors in multivariate analysis (P<0.05 and P<0.00001). Survival was worse in older female patients with low-localised poorly differentiated tumors; however, those variables had not significant impact on prognosis. Neither symptom duration nor mucinous histology was significantly related to survival. Using TME technique a low local recurrence rate resulting in improved survival can be achieved. Apart from clinicopathological staging, elevated s-CEA can identify patients with poor prognosis. In addition to TME adjuvant therapy for this high-risk group should be considered.

show abstract

Section: Discussionsupporting

confidence: 84%

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

Szynglarewicz¹,

Matkowski²,

Forgacz³

et al. 2007

Oncol Rep

View full text Add to dashboard Cite

show abstract

“…Additionally, in rectal cancer, preoperative radiotherapy or chemoradiotherapy have significantly improved survival [9,10]. Well-known prognostic factors after CRC surgery are age, TNM stage, resection margin, tumor grade and the presence of lymphovascular invasion [11][12][13]. The amount of dissected lymph nodes should be at least 12 in order to distinguish between stage II and III CRC [2].…”

Section: Introductionmentioning

confidence: 99%

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

et al. 2017

View full text Add to dashboard Cite

Background: Most survival data in colorectal cancer (CRC) is derived from clinical trials or registerbased studies. Hospital Biobanks, linked with hospital electronic records, could serve as a data-gathering method based on consecutively collected tumor samples. The aim of this Biobank study was to analyze survival of colorectal patients diagnosed and treated in a single-center university hospital over a period of 12 years, and to evaluate factors contributing to outcome.

show abstract

“…So ist diese Rate des berichteten Krankengutes wegen des so genannten "case-mix" auch von in der Rektumkarzinomchirurgie Erfahrenen gelegentlich schwierig zu interpretieren. Wichtige Faktoren sind die Stadienverteilung nach UICC [6], der Malignitätsgrad, das Operationsverfahren (eine tatsächlich abdominoperanal intersphinktäre Resektion erfordernde Operation führt ebenfalls wegen des dann evtl., sehr geringen zirkumferenziellen Sicherheitsabstandes zu einer deutlich höheren Lokalrezidivrate; allerdings beinhaltet dieses Operationsverfahren trotz scheinbar gleicher Definition inhaltlich eine enorme Varianz, die zunächst nicht vorstellbar erscheint und erst nach dem Erfassen detaillierter Hintergründe bis hin zur persönlichen Inaugenscheinnahme einer betreffenden Operation klar wird) [21].…”

Section: Senkung Der Lokalrezidivrateunclassified

Neoadjuvante Radiochemotherapie des Rektumkarzinoms

Hohenberger

Lahmer

Fietkau

et al. 2009

Chirurg

Self Cite

View full text Add to dashboard Cite

Neoadjuvant radiochemotherapy has become established treatment for rectal cancer. It is indicated when primary R0 resection is not an option, in cases of higher risk of locoregional relapse following surgical treatment alone, and when initially impossible conservation of the anal sphincter becomes possible in conjunction with neoadjuvant radiochemotherapy. The indication for radiochemotherapy in the upper third of the rectum is still controversial. Reevaluation of the tumor situation following neoadjuvant treatment is necessary before decisions on operative strategy. Modern imaging techniques are limited in this respect, as they hardly allow differentiation between living tumor tissue and lesions. In case of doubt clarity is possible only through surgical exploration, taking R1 resection into account. Overall the recognition of lymph node metastasis is not a sufficient indicator of local relapse. The frequency of postoperative complications following neoadjuvant radiochemotherapy is independent of the operative method. The effect of neoadjuvant radiochemotherapy on long-term survival and formation of distant metastases is still not clarified. Current studies seek clarification through the use of new chemotherapies and modified treatment regimes. Further, the correct time interval between the end of neoadjuvant radiochemotherapy and the following surgical therapy has yet to be determined. This applies also to the management of patients following complete remission.

show abstract

Survival after surgical treatment of cancer of the rectum

Cited by 17 publications

References 60 publications

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

Clinical factors in prediction of prognosis after anterior resection with total mesorectal excision for carcinoma of the rectum

Trends in presentation, treatment and survival of 1777 patients with colorectal cancer over a decade: a Biobank study

Neoadjuvante Radiochemotherapie des Rektumkarzinoms

Contact Info

Product

Resources

About