2019
DOI: 10.1111/vco.12483
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Survival analysis in dogs with urinary transitional cell carcinoma that underwent whole‐body computed tomography at diagnosis

Abstract: This retrospective study aimed to evaluate factors associated with survival and to compare characteristics between tumour localizations in dogs with urinary transitional cell carcinoma (TCC) that underwent whole‐body computed tomography (CT) at diagnosis. Dogs with histologically confirmed TCC that received medical therapy between 2010 and 2017 were included; dogs that underwent surgery or radiotherapy for the primary tumour were excluded. According to the CT findings, primary tumour localization (classified i… Show more

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Cited by 14 publications
(22 citation statements)
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“…In one large post‐mortem study ( n = 137 cases), 58% of dogs with urothelial cell carcinoma had documented distant metastases 3,6 . Known predilection sites for metastases include MILNs, lungs, liver, skin and vertebral bodies 5,7–9 . Hypertrophic osteopathy has also been seen concurrent to urothelial carcinoma 5 .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In one large post‐mortem study ( n = 137 cases), 58% of dogs with urothelial cell carcinoma had documented distant metastases 3,6 . Known predilection sites for metastases include MILNs, lungs, liver, skin and vertebral bodies 5,7–9 . Hypertrophic osteopathy has also been seen concurrent to urothelial carcinoma 5 .…”
Section: Discussionmentioning
confidence: 99%
“…3,6 Known predilection sites for metastases include MILNs, lungs, liver, skin and vertebral bodies. 5,[7][8][9] Hypertrophic osteopathy has also been seen concurrent to urothelial carcinoma. 5 Stromal osseous metaplasia occurs when part of the tumoral stroma of urothelial carcinomas transforms into mature bone, characterised by bone trabeculae forming a lamellar architecture.…”
Section: Discussionmentioning
confidence: 99%
“…It is especially important to differentiate smooth muscle tumors from urothelial carcinomas (UCs), more commonly known as TCCs, which are the most common urinary bladder tumor in dogs and are often nonsurgical. 1,3,4 TCCs tend to track through the urinary bladder trigone, proximal urethra, and prostate, and they are highly metastatic to the prostate and regional lymph nodes, bones, and lungs. 3,4 Incomplete surgical excision often leads to fast and aggressive recurrence.…”
Section: Commentsmentioning
confidence: 99%
“…1,3,4 TCCs tend to track through the urinary bladder trigone, proximal urethra, and prostate, and they are highly metastatic to the prostate and regional lymph nodes, bones, and lungs. 3,4 Incomplete surgical excision often leads to fast and aggressive recurrence.…”
Section: Commentsmentioning
confidence: 99%
“…Dogs with invasive TCC have different treatment options, including cyclooxygenase (COX) inhibitors (e.g., piroxicam, deracoxib, and pirocoxib) [ 26 , 32 , 34 , 35 , 36 , 38 , 39 , 57 , 63 ], cytotoxic chemotherapy drugs (cisplatin, carboplatin, mitoxantrone, vinblastine, gemcitabine) [ 1 , 19 , 26 , 28 , 34 , 35 , 36 , 39 , 54 ], metronomic chemotherapy (chlorambucil) [ 13 , 20 , 23 , 24 , 47 , 48 , 49 , 64 , 68 , 69 ], laser ablation [ 14 , 26 , 43 ], urethral or ureteral stent placement [ 9 , 26 , 52 , 74 ], surgery [ 11 , 26 , 29 , 34 , 35 , 50 , 54 , 66 , 67 , 70 , 76 , 77 ], and other radiation therapy protocols [ 55 , 56 , 62 , 73 ]; however, a single treatment that leads to a robust response is lacking.…”
mentioning
confidence: 99%