Survival analysis of 459 adult patients with primary spinal cancer in England and Wales: a population-based study

Tseng, Jen-Ho; Tseng, Ming-Yuan

doi:10.1016/j.surneu.2006.04.011

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…We studied the series of 71 patients to evaluate the specific cause of death secondary to the primary disease. After this initial analysis, we identified that metastasis was a significant factor and this data had not been previously described in other publications about survival in spinal cord tumors 4,5 . There were no deaths due to surgical complications in our study group.…”

Section: Discussionmentioning

confidence: 77%

“…Mortality from spinal cord tumors is associated with histological characteristics, particularly the degree of malignancy and the cancer's progression to the upper levels of the spinal cord 4,5,8 . Previous studies on survival basically evaluated mortality in ependymomas and astrocytomas, since other histological types are rare and with biological peculiarities that makes it difficult to analyze them as a group 4,5 . We studied the series of 71 patients to evaluate the specific cause of death secondary to the primary disease.…”

Section: Discussionmentioning

confidence: 99%

“…A multicenter French study on spinal cord tumors, with 73 patients operated on between 1971 and 1994 showed that malignant histology (relative risk (RR)=7.69) and clinical time of less than four months were the most important prognostic factors associated with death (RR=4.93) 4 . Tseng and Tseng conducted a study with 459 patients and demonstrated that age at the time of diagnosis (RR=2.67), high histology classification grade (RR=3.01) and types of neoplasms different from ependymomas (RR=3.51) impact mortality prognosis in patients with spinal cord tumors 5 . We studied all the cases that underwent surgery at the SARAH Network and found that malignant histology (RR=8.47) and presence of metastasis (RR=5.50) were the two most important factors associated with death (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…They correspond to more than 80% of the cases and usually present benign clinical and histological characteristics 2,3 . Although these tumors have been studied for many years, there are few publications about mortality or analysis of survival rates in patients with intramedullary tumors 4,5 . Previous studies about mortality from neoplasm of the spinal cord specifically identified the malignancy in the histopathology as being the most important predictive factor, but they did not address death due to metastatic dissemination 4 .…”

Section: Mortality Is Higher In Patients With Leptomeningeal Metastasmentioning

confidence: 99%

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Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors

Gepp

Couto

Silva

et al. 2013

Arq. Neuro-Psiquiatr.

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Spinal cord tumors are a rare neoplasm of the central nervous system (CNS). The occurrence of metastases is related to poor prognosis. The authors analyzed one series of metastasis cases and their associated mortality. METHODS: Clinical characteristics were studied in six patients with intramedullary tumors with metastases in a series of 71 surgical cases. RESULTS: Five patients had ependymomas of which two were WHO grade III. The patient with astrocytoma had a grade II histopathological classification. Two patients required shunts for hydrocephalus. The survival curve showed a higher mortality than the general group of patients with no metastases in the CNS (p<0.0001). CONCLUSION: Mortality is elevated in patients with metastasis and greater than in patients with only primary lesions. The ependymomas, regardless of their degree of anaplasia, are more likely to cause metastasis than spinal cord astrocytomas.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Mortality Is Higher In Patients With Leptomeningeal Metastasmentioning

confidence: 99%

See 2 more Smart Citations

Mortality is higher in patients with leptomeningeal metastasis in spinal cord tumors

Gepp

Couto

Silva

et al. 2013

Arq. Neuro-Psiquiatr.

View full text Add to dashboard Cite

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“…The other variables analyzed in that study did not show statistical difference, and gross total removal of intramedullary tumors did not correlate with increased survival rates 10 . More recently, another study from England with 453 adults patients showed that extension of tumor resection did not correlate with improvement in survival rates 11 . We believe that the aim of surgery in intramedullary tumors should be radical removal, although this is possible only in cases where there is cleavage plane.…”

Section: Postoperative Clinical Statusmentioning

confidence: 99%

Intramedullary tumors in children: analysis of 24 operated cases

Gepp

Couto

Silva

et al. 2010

Arq. Neuro-Psiquiatr.

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Intramedullary tumors are rare. The authors reviewed 24 cases operated between 1996 and 2006. The study assessed the clinical characteristics and surgical results based upon the neurological function. Method: Medical records of patients with intramedullary astrocytoma and ependymoma were reviewed. The minimal follow up time was 6 months and, at the end of this period, a comparative analysis of the neurological function was performed based using the McCormick scale score. results: Most patients had astrocytoma (75%). Male gender was more prevalent (58.3%). The most common type of tumor was graded as I or II, and in three cases these were malignant. The total resection of the tumor was achieved in 20.8% of the cases. The statistical analysis did not show a statistically significant difference between preoperative and postoperative grades at McCormick scale. conclusion: The authors concluded that microsurgery to intramedullary tumors did not significantly alter the neurological function after six months. Key words: astrocytoma, ependymoma, microsurgery, spinal cord.tumores intramedulares em crianças: análise de 24 casos operados resuMo Os tumores intramedulares são doenças raras. Os autores analisaram 24 casos operados entre 1996 e 2006. O estudo analisou as características clínicas e o resultado da cirurgia quanto à função neurológica. Método: Foram analisados pacientes com astrocitomas e ependimomas intramedulares. O tempo mínimo de acompanhamento foi de 6 meses e ao final deste período foi realizada a avaliação comparativa da variação do estado neurológico baseado na escala de McCormick. resultados: A maioria dos pacientes era de astrocitoma (75%). O gênero masculino foi mais prevalente (58,3%). A maioria dos tumores era de grau I ou II, 3 casos eram malignos. A ressecção total do tumor ocorreu em 20,8% dos casos. A avaliação estatística demonstrou que não houve diferença significativa entre o estado neurológico na escala de McCormick pré-operatória e pós-operatória. conclusões: Os autores concluem que a microcirurgia para ressecção dos tumores intramedulares não ocasionou variação funcional significativa nos pacientes após seis meses da cirurgia. Palavras-chave: astrocitoma, ependimoma, microcirurgia, medula espinhal.

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