Survival analysis of colorectal cancer patients with tumor recurrence using global score test methodology

Zain, Zakiyah; Aziz, Nazrina; Ahmad, Yuhaniz; Azwan, Zairul; Raduan, Farhana; Sagap, Ismail

doi:10.1063/1.4903697

Cited by 1 publication

(2 citation statements)

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“…Following its success in categorical and binary data, global score test methodology has recently been used successfully in bivariate survival analysis [5,10,11]. Theoretically, the method of ZW for bivariate cases shall work for multivariate cases involving more than two survival times.…”

Section: Discussionmentioning

confidence: 99%

“…Using the global score test methodology, Zain and Whitehead [10] have also discussed cases of time-toprogression (TTP) and progression-free-survival (PFS) in relation to the overall survival (OS). Adopting the same methodology, Zain et al [11] have analyzed real data of colorectal cancer patients in Malaysia. The bivariate survival data were categorized into multiple intervals and the score statistic Z and Fisher's information, V, were derived from complementary log-log approach.…”

Section: Correlation Estimatormentioning

confidence: 99%

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Simplifying multivariate survival analysis using global score test methodology

Zain¹,

Aziz²,

Ahmad³

2015

AIP Conference Proceedings

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In clinical trials, the main purpose is often to compare efficacy between experimental and control treatments. Treatment comparisons often involve multiple endpoints, and this situation further complicates the analysis of survival data. In the case of tumor patients, endpoints concerning survival times include: times from tumor removal until the first, the second and the third tumor recurrences, and time to death. For each patient, these endpoints are correlated, and the estimation of the correlation between two score statistics is fundamental in derivation of overall treatment advantage. In this paper, the bivariate survival analysis method using the global score test methodology is extended to multivariate setting.

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Section: Discussionmentioning

confidence: 99%

Section: Correlation Estimatormentioning

confidence: 99%