Survival analysis of colorectal cancer patients in a Thai hospital-based cancer registry

Kittrongsiri, Kankamon; Wanitsuwan, Worawit; Prechawittayakul, Paradee; Sangroongruangsri, Sermsiri; Cairns, John; Chaikledkaew, Usa

doi:10.1080/17474124.2020.1740087

Cited by 16 publications

(14 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We found that the 5-year OS of Vietnamese patients with CRC was approximately 60% lower than those in Asian countries (Moghimi-Dehkordi and Safaee, 2012). Our findings are equivalent to those of neighboring countries, such as Thailand (Phimha et al, 2019;Kittrongsiri et al, 2020) al., 2020). In the literature, the survival rate can reflect the quality of healthcare services, such as an accurate diagnosis, effective management, and treatment of cancer patients (Coleman et al, 2011).…”

Section: Discussionsupporting

confidence: 87%

See 1 more Smart Citation

Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam

Sarakarn

2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: This study investigated the overall survival (OS) at 1-year, 3-years, and 5-years after colorectal cancer (CRC) diagnosis and examined the prognostic factors of mortality among patients with CRC in Vietnam's central region. Methods: This ambidirectional cohort study included patients newly diagnosed with CRC at a tertiary hospital in Vietnam's central region between 2013 and 2019. Survival duration was calculated from the surgery date or the first day of CRC-specific treatment until the date of death or the study's end date, July 31, 2020. Kaplan-Meier methods and log-rank test were used to estimate and compare the OS between the subgroups, respectively. The Cox proportional-hazards (PH) regression analysis was applied to estimate the magnitude of the effects between prognostic factors and outcome. Results: The median follow-up was 24 months (interquartile range: 13-43 months). The OS rate dropped significantly to 84.7%, 56.19%, and 45.01% at 1-year, 3-years, and 5-years after diagnosis, respectively. The median OS was 48.59 months (39.34 -57.93 months) for the rectum and colon cases. In the multivariate analysis, a higher mortality risk was observed in patients with an advanced-stage CRC (HRadj, 3.04; 95% confidence interval [CI], 1.79-5.18), who were underweight (<18.5 kg/m2; HRadj, 1.65; 95%CI, 1.03-2.65), and had elevated preoperative carcinoembryonic antigen (CEA) level (>5.0 ng/mL; HRadj, 1.63; 95%CI, 1.03-2.59). Additionally, younger patients (<50 years) had a poorer OS than the middle-aged group (60-69 years). Conclusion: Our findings indicate that <50% of Vietnamese patients with CRC survive until 5-years after diagnosis. Several individual factors that contribute to the poor OS of patients with CRC, including young age, underweight, and elevated preoperative CEA level, should be evaluated and managed. Early diagnoses through active routine examination of or screening programs for high-risk groups should be prioritized.

show abstract

Section: Discussionsupporting

confidence: 87%

“…The relationship between age at diagnosis and outcome of CRC patients has been consistently reported in many previous studies (Van et al, 2015;Sharkas et al, 2017;Gabriel et al, 2018;Kittrongsiri et al, 2020;Leong et al, 2020). Currently, the aging population trend is occurring worldwide, including Vietnam.…”

Section: Discussionmentioning

confidence: 63%

Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam

Sarakarn

2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

“…Essentially, cancers occurring within 2 months of each other are deemed synchronous, whereas those developing later than 2 months are regarded as metachronous [9]. As the Universal Health Coverage system achieves in Thailand that more than 90% of the population can access healthcare systems [14], the survival of some cancer trends to increase [15]. Although, some site-specific cancer care survivorship guidelines were existed [16,17], the development of appropriate surveillance strategies should be studied for improving the quality of life in Thai cancer population.…”

Section: Introductionmentioning

confidence: 99%

Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study

et al. 2021

View full text Add to dashboard Cite

Background The situation of patients developing multiple primary cancers is becoming more frequent and graver. This study investigated the risks of developing second primary cancers that are related to first primary cancers, and the interval times of synchronous and metachronous multiple primary cancers. Patients and methods Retrospective data were retrieved from 109,054 patients aged ≥18 who were diagnosed with a first solid cancer and registered at Siriraj Cancer Center between 1991 and 2015. A two-month period between first- and second- primary cancers was used to differentiate metachronous and synchronous multiple primary cancers. The combinations of subsequent cancers and relative risks (RRs) of having multiple primary cancers versus having single primary cancer for the top-ten first and second primary cancers were examined. The RR was adjusted for age of the first primary cancer. A survival analysis of the time to second-primary-cancer development was performed. Results Multiple primary cancers were found in 1785 (1.63%) patients. Most (70.87%) second primary cancers occurred after 2 months of first breast, skin, colorectal, lung, head and neck, liver, male genital cancer–prostate, thyroid, and female genital cancer–non-uterine cancers, resulting in those cancers being classified as metachronous multiple primary cancer. After adjustment for age at first diagnosis, head and neck cancers had the highest metachronous association with second esophageal cancers (RR, 25.06; 95% CI, 13.41–50.77). Prostate cancer and second colorectal cancer also demonstrated a high metachronous association (RR, 2.00; 95% CI, 1.25–3.05). A strong synchronous association was found between uterine and ovarian cancers (RR, 27.77; 95% CI, 17.97–43.63). The median time from the first uterine cancer to second-cancer development was 55 days. Conclusions The top-ten most frequent multiple primary cancers were the following: breast; liver; head and neck; colorectal; male genital cancer–prostate; skin; female genital cancer–uterine; thyroid; lung; and female genital cancer–non-uterine. Second primary cancers showed specific associations that depended on the first primary cancer. Physicians should be cognizant of the most common combinations and the interval times of metachronous and synchronous multiple primary cancers.

show abstract

“…The staging at diagnois was the only significant prognostic factor for colorectal cancer in Sabah. A higher overall survival was noted in some of the Asian countries such as Thailand and Philippines, which were 44.0% and 40.2% respectively (Kittrongsiri et al, 2020;Laudico et al, 2010). Singapore estimated the overall survival for colorectal cancer was 51.0% for males and 52.8% for females (Ministry of Health Singapore, 2017).…”

Section: Discussionmentioning

confidence: 99%

Survival Rate and Prognostic Factors for Colorectal Cancer in Sabah, Borneo, Malaysia: A Retrospective Cohort of a Population-Based Study

Amir

Avoi

Yusof

et al. 2022

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

show abstract

Survival analysis of colorectal cancer patients in a Thai hospital-based cancer registry

Cited by 16 publications

References 22 publications

Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam

Overall Survival Rate of Vietnamese Patients with Colorectal Cancer: A Hospital-Based Cohort Study in the Central Region of Vietnam

Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study

Survival Rate and Prognostic Factors for Colorectal Cancer in Sabah, Borneo, Malaysia: A Retrospective Cohort of a Population-Based Study

Contact Info

Product

Resources

About