Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking

Farshadpour, F.; Kranenborg, Hanneke; Calkoen, Eveline Van Beeck; Hordijk, G. J.; Koole, R.; Slootweg, Piet J.; Terhaard, Chris H.J.

doi:10.1002/hed.21549

Cited by 60 publications

(49 citation statements)

References 22 publications

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“…Laryngeal carcinoma is one of the most common malignancies of the head and neck, and squamous cell carcinoma is the most frequent histological type of laryngeal carcinoma, accounting for 98% of cases 19, 20 . The main risk factors for this cancer include tobacco smoking and alcohol consumption, and the roles of these risk factors have been consistently confirmed by a growing number of studies 21, 22 . The larynx is a part of the upper airway that harbors large populations of Firmicutes, Proteobacteria , and Bacteroidetes ; however, the profiles of the bacterial communities at this site are different from those at other anatomical locations in the respiratory system 23 .…”

Section: Introductionmentioning

confidence: 77%

Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

Gong

Shi

Xiao

et al. 2017

Sci Rep

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The microbial communities that inhabit the laryngeal mucosa build stable microenvironments and have the potential to influence the health of the human throat. However, the associations between the microbiota structure and laryngeal carcinoma remain uncertain. Here, we explored this question by comparing the laryngeal microbiota structure in laryngeal cancer patients with that in control subjects with vocal cord polyps through high-throughput pyrosequencing. Overall, the genera Streptococcus, Fusobacterium, and Prevotella were prevalent bacterial populations in the laryngeal niche. Tumor tissue samples and normal tissues adjacent to the tumor sites (NATs) were collected from 31 laryngeal cancer patients, and the bacterial communities in laryngeal cancer patients were compared with control samples from 32 subjects. A comparison of the laryngeal communities in the tumor tissues and the NATs showed higher α-diversity in cancer patients than in control subjects, and the relative abundances of seven bacterial genera differed among the three groups of samples. Furthermore, the relative abundances of ten bacterial genera in laryngeal cancer patients differed substantially from those in control subjects. These findings indicate that the laryngeal microbiota profiles are altered in laryngeal cancer patients, suggesting that a disturbance of the microbiota structure might be relevant to laryngeal cancer.The human microbiota can be considered an organ composed of mixed species with functions that enable the construction of a polymicrobial assemblage 1, 2 . Microbial communities are abundant and relatively stable in the human body, which is constantly exposed to these microbial factors, and these communities play a fundamental role in regulating the health and physiology of the host via cooperative and competitive interactions [3][4][5] . Indeed, aberrations in the microbiota profiles play causative roles in the development of many clinical diseases, such as periodontitis, obesity, inflammatory bowel disease, diabetes mellitus, metabolic syndrome, atherosclerosis, and liver cirrhosis [6][7][8][9][10][11][12] . Specifically, differences in the relative abundance of certain microbial communities have been observed in cancer patients, indicating that disturbances in this multispecies synergy might be an important factor related to tumorigenesis [13][14][15] . Recently, the use of animal models possessing the same molecular pathway mechanisms observed in vivo has suggested that disruption of the microbiota can promote tumor initiation and development [16][17][18] . However, the mechanisms through which microbial factors influence susceptibility to laryngeal carcinoma remain elusive. Laryngeal carcinoma is one of the most common malignancies of the head and neck, and squamous cell carcinoma is the most frequent histological type of laryngeal carcinoma, accounting for 98% of cases 19,20 . The main risk factors for this cancer include tobacco smoking and alcohol consumption, and the roles of these risk factors have been consistentl...

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Section: Introductionmentioning

confidence: 77%

Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

Gong

Shi

Xiao

et al. 2017

Sci Rep

View full text Add to dashboard Cite

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“…2d , survival times were censored after three years to show the specific effect within this time window, but all other figures and all statistics cited in the paper use five-year survival. While data on comorbidity is limited for this cohort, from other studies we can estimate the competing mortality within this time-frame to be about 20% 28,29 . We expect the actual effect of such confounding to be minimal as separation in the survival curves that we observe generally occurs within the first two years, during which time we expect non-cancer associated death rates to be much lower.…”

Section: Methodsmentioning

confidence: 93%

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

et al. 2014

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Head and neck squamous cell carcinoma (HNSCC) is characterized by aggressive behavior with a propensity for metastasis and recurrence. Here we report a comprehensive analysis of the molecular and clinical features of HNSCC that govern patient survival. We find that TP53 mutation is frequently accompanied by loss of chromosome 3p, and that the combination of both events associates with a surprising decrease in survival rates (1.9 years versus >5 years for TP53 mutation alone). The TP53-3p interaction is specific to chromosome 3p, rather than a consequence of global genome instability, and validates in HNSCC and pan-cancer cohorts. In Human Papilloma Virus positive (HPV+) tumors, in which HPV inactivates TP53, 3p deletion is also common and associates with poor outcomes. The TP53-3p event is modified by mir-548k expression which decreases survival even further, while it is mutually exclusive with mutations to RAS signaling. Together, the identified markers underscore the molecular heterogeneity of HNSCC and enable a new multi-tiered classification of this disease.

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“…These observations illustrate the capacity of these risk factors to favor the development of cancers simultaneously or successively at various sites, and justify to reinforce prevention on such major nutritional risk factors. Alcohol consumption at index diagnosis of UADT cancer has been associated with significantly increased mortality and recurrence (41)(42)(43)(44)(45)(46). Moreover, quitting drinking after UADT cancer diagnosis has been shown to be associated with a better prognosis (44,47).…”

Section: Discussionmentioning

confidence: 99%

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

Druesne-Pecollo

Keita

Touvier

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: We conducted a systematic review and meta-analysis of existing data from observational studies to assess the strength of the association of alcohol drinking with second primary cancer risk in patients with upper aerodigestive tract (UADT; oral cavity, pharynx, larynx, and esophagus) cancer.Methods: PubMed and Embase were searched up to July 2012 and the reference lists of studies included in the analysis were examined. Random-effects models were used to estimate summary relative risks (RR) and 95% confidence interval (CI).Results: Nineteen studies, 8 cohort and 11 case-control studies, were included. In highest versus lowest meta-analyses, alcohol drinking was associated with significantly increased risk of UADT second primary cancers (RR, 2.97; 95% CI, 1.96-4.50). Significantly increased risks were also observed for UADT and lung combined (RR, 1.90; 95% CI, 1.16-3.11) and all sites (RR, 1.60; 95% CI, 1.22-2.10) second primary cancers. For an increase in the alcohol intake of 10 grams per day, dose-response meta-analysis resulted in a significantly increased RR of 1.09 (95% CI, 1.04-1.14) for UADT second primary cancers.Conclusions: Alcohol drinking in patients with UADT cancer is associated with an increased risk of second primary cancers. Studies conducted in alcohol drinking patients with UADT cancer and evaluating the effect of alcohol cessation on second primary cancer and other outcomes are needed.Impact: Our results emphasize the importance of prevention policies aiming to reduce alcohol drinking. Health-care professionals should encourage alcohol drinking patients with UADT cancer to reduce their consumption and reinforce the surveillance of this at-risk subpopulation. Cancer Epidemiol Biomarkers Prev; 23(2); 324-31. Ó2013 AACR.

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Survival analysis of head and neck squamous cell carcinoma: Influence of smoking and drinking

Abstract: Although tobacco and alcohol use are the main risk factors for development of HNSCC, disease outcome was comparable in patients who did or did not use these substances. Tobacco and alcohol use affected overall survival, which emphasizes the importance of substance use cessation.

Cited by 60 publications

References 22 publications

Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

Alterations of microbiota structure in the larynx relevant to laryngeal carcinoma

Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss

Alcohol Drinking and Second Primary Cancer Risk in Patients with Upper Aerodigestive Tract Cancers: A Systematic Review and Meta-analysis of Observational Studies

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