Survival Analysis of Nasopharyngeal Carcinoma in Hassan Sadikin Hospital

Adriana, Riska; Dewi, Yussy Afriani; Samiadi, Dindy; Candra, Edo Wira

doi:10.32734/ijnpc.v1i1.952

Cited by 4 publications

(6 citation statements)

References 17 publications

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“…A similar pattern is shown in America (72%, 64%, 62%, and 38%). In our center, the five-year survival rate is 30.9%, with a much lower survival rate in stage I (44.6%) [3].…”

Section: Introductionmentioning

confidence: 63%

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Laboratory Profiles of Nasopharyngeal Carcinoma Patients

Aroeman¹,

Nazar²,

Dewi³

2021

Advances in Health Sciences Research

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Nasopharyngeal Carcinoma (NPC) is one of the most common head and neck malignant neoplasms worldwide. Laboratory profile is rarely evaluated in Indonesia as a prognostic consideration. The aim of this research is to describe the laboratory profile of NPC patients. This is descriptive research using a total sampling method from 2016-to 2020. The general characteristics and laboratory profiles are collected from Nasopharyngeal Cancer Registry. The data collected will be presented in tables as frequency and percentages. More than half of the participants were male (68.27%), aged more than 45 years old (65.38%). The majority of the subjects reported a KPS of more than 80 (84.94%). Most of the participants showed WHO type III (47.57%). Bone (42.22%) was the most common metastases site. Normal hemoglobin (57.14%), leukocyte (57.99%), thrombocyte (91.36%), ALP (81.82%), AST (89.66%), ALT (61.26%), direct bilirubin (76.00%), indirect bilirubin (63.30%), total bilirubin (86.60%) and urea (84.10%) levels were found in most of our subjects. Calcium <8.6 mg/dL (92.21%) and creatinine >1.5 mg/dL (69.2%) were observed in most cases. This study indicated a worse prognosis by anemia, leukocytosis, and a high De Ritis ratio. In comparison, a better prognosis is predicted by low ALP levels, high calcium, direct bilirubin, and total bilirubin. In addition, pretreatment laboratory profiles should be assessed to predict the prognosis of patients with NPC.

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“…A similar pattern is shown in America (72%, 64%, 62%, and 38%). In our center, the five-year survival rate is 30.9%, with a much lower survival rate in stage I (44.6%) [3].…”

Section: Introductionmentioning

confidence: 63%

“…A previous study in our center reported that most patients with NPC mainly seek professional help due to neck lymph node metastases. The advanced stage contributes to the high mortality rate of NPC, stage III 15.4%, stage IVA 13.8%, and stage IVB 1.5% [3,14].…”

Section: Discussionmentioning

confidence: 99%

Laboratory Profiles of Nasopharyngeal Carcinoma Patients

Aroeman¹,

Nazar²,

Dewi³

2021

Advances in Health Sciences Research

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“…Similar results were found in the study by Adriana who showed 84.9% of Stage III and IV patients, and the study in Ethiopia showed 86.2%. Studies in endemic areas show 80−90% of Stage III and IV cases [17], [18]. This could indicate the difficulty of early diagnosis due to the vague symptoms that arise in the early stages [19].…”

Section: Discussionmentioning

confidence: 99%

“…Intensive systemic treatment such as chemoradiation is needed to treat patients with NPC in Stages III and IV due to the predisposition to distant metastases as one of the primary causes of treatment failure and death in NPC patients [20]. Various studies also have shown that giving chemoradiation to NPC patients exhibits a higher survival rate than giving only radiotherapy [17], [21], [22].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

Susanto

Dewi

Saputri

2022

Open Access Maced J Med Sci

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BACKGROUND: Nasopharyngeal carcinoma (NPC) is a head-and-neck cancer that develops in the epithelial lining of the nasopharynx. The provision of radiotherapy and chemoradiation therapy in NPC can be evaluated by assessing the tumor response. AIM: The present study aims to determine the response in patients with nasopharyngeal carcinoma (NPC) to radiotherapy and chemoradiation therapy. METHODOLOGY: The study design is a retrospective bivariate analytic study from the Otorhinolaryngology-Head and Neck Society Head-Neck Surgical Oncology data registry program for the period of 2016−2021 at Dr. Hasan Sadikin General Hospital, Bandung. A total sample of 447 patients with NPC was used, and data were processed with descriptive and bivariate analytical tests. The variables used were patient characteristics and tumor response to radiotherapy and chemoradiation therapy. The tumor response was obtained based on the results of the examination at least 3 months after the administration of therapy and categorized according to the Response Evaluation Criteria in Solid Tumors 1.1 (RECIST 1.1). RESULTS: Three hundred and eighty-three NPC patients (252 men and 131 women) underwent chemoradiation or radiation therapy, and their tumor response had been evaluated. Most patients were diagnosed at Stages III and IV and treated by chemoradiation. In total, 314 of 383 patients (82%) achieved CR (complete response), 50 patients (13.1%) achieved PR (partial response), 11 patients (2.9%) had PD (progressive disease), and 8 (2.1%) patients had SD (stable disease). There is no statistically significant difference in the type of therapy response when correlated with the each of the variables; age, sex, and educational level (p > 0.05). There is a statistically significant difference in the type of therapy response among different clinical stage groups (p < 0.0001). CONCLUSION: Most nasopharyngeal carcinoma patients in the study had a complete response (82%) for either chemoradiation or radiotherapy alone. Age, sex, and education level have no significant effect on therapy response. On the other hand, the response to therapy is significantly correlated to the clinical stage of the disease.

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“…8 Survival is the percentage of individuals living in a group with a certain disease in a specified period. 9 Several factors are believed to affect the survival of laryngeal carcinoma, including patient and tumor factors. 10 This study aims to show the survival of patients with laryngeal carcinoma in Indonesia.…”

Section: Introductionmentioning

confidence: 99%

An Analytical Study: Survival Rate of Laryngeal Carcinoma Patients Among Indonesian Population

Bawa¹,

Aroeman²,

Dewi³

2021

PJMHS

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Introduction: Laryngeal carcinoma is a malignant squamous metaplasia of the overlying epithelial surface of larynx. Several factors are believed to affect the survival of laryngeal carcinoma. This study aims to identify the survival of patients with laryngeal carcinoma. Materials and Methods: This was a retrospective cohort study using Cox Regression analysis for the survival analysis design. Patients were included if they were diagnosed with laryngeal cancer, had radiotherapy, chemotherapy, surgery or combination therapy and had a complete medical record. Data were collected retrospectively from medical records, such as smoking, alcohol consumption, genetic, tumor location, stadium, and therapy. Result: The results shows that from the 149 patients with laryngeal carcinoma who came to Head and Neck Surgery oncology outpatient clinic and had received therapy in the period January 2009 to December 2014, it was founded that smoking, alcohol, genetic, staging, surgery, and chemotherapy had a significant relationship to the laryngeal carcinoma survival (p value <0.05). While the location of the tumor and radiation did not show a significant relationship (p value> 0.05). Based on multivariable analysis of Cox Regression obtained smoking, alcohol, and surgery which provides a significant influence on survival. Patients who smoke have a risk of death 23.9 times. Suffering from consuming alcohol has a risk 2.41 times of death. Patients who do surgery can reduce the risk of death about 54%. Conclusion: The 5-year survival of patients with laryngeal carcinoma is 56.4%. Keywords: Patient Factors, Prognostic Factors, Tumor Factors, Laryngeal Carcinoma, Survival

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Survival Analysis of Nasopharyngeal Carcinoma in Hassan Sadikin Hospital

Cited by 4 publications

References 17 publications

Laboratory Profiles of Nasopharyngeal Carcinoma Patients

Laboratory Profiles of Nasopharyngeal Carcinoma Patients

Assessment of Response to Chemoradiation and Radiation Therapy in Patients with Nasopharyngeal Carcinoma

An Analytical Study: Survival Rate of Laryngeal Carcinoma Patients Among Indonesian Population

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