Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy

Lifsics, Andrejs; Rate, Elza; Иванова, А. С.; Tars, Juris; Murovska, Modra; Groma, Valērija

doi:10.32471/exp-oncology.2312-8852.vol-42-no-1.14147

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Cox regression analysis indicated that advanced clinical stages were associated with poorer survival in OSCC patients. This result is compatible with other studies showing that patients with OSCC are commonly diagnosed late, a fact that negatively influences their prognosis ( 16 , 25 ). This late diagnosis has been attributed to factors such as the absence of initial symptoms, the patient’s lack of knowledge about the disease, and the fear of diagnosis.…”

Section: Discussionsupporting

confidence: 93%

Survival and prognostic factors in patients with oral squamous cell carcinoma

Ak¹,

Sh²,

Granville-Garcia³

et al. 2021

Med Oral

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Background This study aimed to evaluate sociodemographic and clinical factors influencing overall survival (OS) in patients with oral squamous cell carcinoma (OSCC). Material and Methods Medical charts of 547 patients with OSCC from a public hospital in northeastern Brazil seen between 1999 and 2013 were evaluated. Survival analysis was performed using the Kaplan-Meier method. The influence of age, sex, ethnicity, clinical stage, anatomical location, type of treatment, and comorbidities on the patients’ prognosis was evaluated. Cox proportional hazards regression model was used to identify independent prognostic factors. Results The 5-year OS was 39%. Multivariate analysis showed that age < 40 years (HR = 2.20; 95%CI: 1.02-4.72) and a single treatment modality (HR = 1.91; 95%CI: 1.37-2.67) were associated with a poor prognosis, while early clinical stage resulted in better outcomes (HR = 0.38; 95%CI: 0.25-0.58). Conclusions OSCC patients in advanced clinical stages, diagnosed at a younger age, and submitted to a single therapeutic modality have a poorer prognosis. Key words: Head and neck cancer, oral cancer, oral squamous cell carcinoma, survival, prognosis.

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Section: Discussionsupporting

confidence: 93%

Survival and prognostic factors in patients with oral squamous cell carcinoma

Ak¹,

Sh²,

Granville-Garcia³

et al. 2021

Med Oral

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show abstract

“…This difference may be explained by different lifestyles, preferences, and sexual habits. Notably, smoking, recognized as a significant factor influencing the development of head and neck cancer, is a common hazard in Latvian society [52]. However, the present study suggests a role of HPV in the carcinogenesis of non-oropharyngeal cancer and points at HPV16 being a predominant HPV type confirmed in LSCC and HPSCC.…”

Section: Discussioncontrasting

confidence: 51%

Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas

Lifsics

Groma

Cistjakovs

et al. 2021

Viruses

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Human papillomavirus (HPV) was proven to play a significant role in cancer development in the oropharynx. However, its role in the development of laryngeal (LSCC) and hypopharyngeal squamous cell carcinoma (HPSCC) remains to be clarified. High-risk HPV (HR-HPV) viral proteins E6 and E7 are considered to be pertinent to HPV-related carcinogenesis. Hence, our aim was to estimate LSCC and HPSCC for HR-HPV DNA, p16, and E6/E7 oncoprotein status by using molecular virology and immunohistochemistry methods. The prevalence of HPV16 infection was 22/41 (53.7%) and 20/31 (64.5%) for LSCC and HPSCC, accordingly. The majority of HPV16+ tumor samples were stage III or IV. In most samples, the presence of either HPV16 E6 or HPV16 E7 viral protein in dysplastic or tumor cells was confirmed using immunohistochemistry. Our results suggest a high prevalence of HPV16 as a primary HR-HPV type in LSCC and HPSCC. The lack of HPV E6/E7 oncoproteins in some tumor samples may suggest either the absence of viral integration or the presence of other mechanisms of tumorigenesis. The utilization of p16 IHC as a surrogate marker of HR-HPV infection is impractical in LSCC and HPSCC.

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HPV-Induced Oropharyngeal Squamous Cell Carcinomas in Brazil: Prevalence, Trend, Clinical, and Epidemiologic Characterization

Carvalho

Scapulatempo‐Neto²,

Curado

et al. 2021

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Tobacco or human papillomavirus (HPV)-related oropharyngeal squamous cell carcinomas (OPSCC) represent different clinical and epidemiologic entities. This study investigated the prevalence of HPV-positive and HPV-negative OPSCC in a reference cancer hospital in Brazil and its association with clinical and demographic data, as well as its impact on overall survival. Methods: HPV infection was determined by p16-IHC in pre-treatment formalin-fixed paraffin-embedded samples from all patients with OPSCC diagnosed at Barretos Cancer Hospital between 2008 and 2018. The prevalence of HPV-positive cases and its temporal trend was assessed, and the association of clinical and demographic data with HPV infection and the impact on patient overall survival was evaluated. Results: A total of 797 patients with OPSCC were included in the study. The prevalence of HPV-associated tumors in the period was 20.6% [95% confidence interval, 17.5–24.0] with a significant trend for increase of HPV-positive cases over the years (annual percentage change = 12.87). In a multivariate analysis, the variables gender, level of education, smoking, tumor sublocation, region of Brazil, and tumor staging had a significant impact in HPV positivity, and a greater overall survival (OS) was observed in HPV-positive patients (5-year OS: 47.9% vs. 22.0%; P = 0.0001). Conclusions: This study represents the largest cohort of Brazilian patients with OPSCC characterized according to HPV status. We report significant differences in demographics and clinical presentation according to HPV status, and an increasing trend in prevalence for HPV-induced tumors. Impact: These findings can potentially contribute to a better stratification and management of patients as well as assist in prevention strategies.

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Survival analysis of oropharyngeal squamous cell carcinoma patients linked to histopathology, disease stage, tumor stage, risk factors, and received therapy

Cited by 3 publications

References 34 publications

Survival and prognostic factors in patients with oral squamous cell carcinoma

Survival and prognostic factors in patients with oral squamous cell carcinoma

Identification of High-Risk Human Papillomavirus DNA, p16, and E6/E7 Oncoproteins in Laryngeal and Hypopharyngeal Squamous Cell Carcinomas

HPV-Induced Oropharyngeal Squamous Cell Carcinomas in Brazil: Prevalence, Trend, Clinical, and Epidemiologic Characterization

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