Survival Analysis of Patients with Bladder Cancer after Radical Cystectomy

Abstract

One of the most commonly used surgical operations among patients with bladder cancer (BC) is radical cystectomy (RC), which includes the removal of the entire bladder along with the surrounding lymph nodes and other nearby organs that are affected by malignant neoplasms. During this operation, the most important stage that has a direct impact on the further quality of life of the patient is the choice of the method of uroderivation (UD). Patients and Methods: Have been reviewed retrospectively the clinical records of 586 patients who had BC RC at the Oncourological Department of the Sverdlovsk Regional Oncological Dispensary (SROD) between December 2001 and May 2021 after RC with three methods of UD: external urine removal, internal urine removal, intestinal reservoir. Results: The direct dependence of the presence and severity of some complications after RC on the method of urine removal chosen by the oncologist surgeon were determined. The analysis of survival curves was carried out, as well as the 5- and 10-year survival rate of patients of the SROD after RC. According to the results of the analysis, it was found that the worst survival was observed in patients with external urine diversion, the best survival was found in patients with internal urine diversion (p < 0.05). Conclusions: Urinary diversion is definitely an important stage in the performance of such a surgical intervention as RC. The study revealed statistically significant differences between patient survival curves (p < 0.05) plotted for different groups of urinary diversion and differences between the medians of several types of survival for the groups considered (p < 0.05).