Survival analysis of patients with oral squamous cell carcinoma with simultaneous second primary tumors

Hsu, Shuo–Hsiu; Wong, Yong–Kie; Wang, Ching‐Ping; Jiang, Rong–San; Chen, Fun–Jou; Liu, Shih–An

doi:10.1002/hed.23242

Cited by 19 publications

(11 citation statements)

References 15 publications

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“…It is a growing global health issue, particularly in developing countries [1,2]. Oral cancer has a relatively low 5-year survival rate of 50% or less when compared with other major types of cancers, such as breast, skin, prostate, and urinary bladder cancers [3].…”

Section: Introductionmentioning

confidence: 99%

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

et al. 2017

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ObjectivesWe aimed to explore the relationship between the time interval from diagnosis to treatment and survival of oral cavity squamous cell carcinoma patients.Materials and methodsA population-based study was conducted between 2004 and 2010. Claims data of oral squamous cell carcinoma patients were retrieved from the Taiwan Cancer Registry Database. Secondary data were obtained from Taiwan’s National Health Insurance Research Database.ResultsA total of 21,263 patients were included in the final analysis. The majority of the patients received treatment within 30 days of diagnosis (n = 18,193, 85.5%), while 572 patients (2.7%) underwent treatment after 120 days. The patients who were treated after 120 days had a higher risk of death when compared to those treated within 30 days (Hazard ratio: 1.32, 95% Confidence intervals: 1.19 to 1.47).ConclusionA longer time interval from diagnosis to treatment was found to be associated with a poorer prognosis among patients suffering from oral squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

et al. 2017

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“…No marked progress in the management of oral cavity cancer has been made in recent years. Although the combinations of therapeutic protocols has improved the patient’s quality of life, the 5-year survival rate remains unchanged 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

Liu

Wang

Jiang

et al. 2017

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We investigated the relationship of different primary subsites together with their pathological features on the survival of oral cavity squamous cell carcinoma (OCSCC) patients. We retrospectively reviewed OCSCC patients and documented their demographic data, pathological features and clinical outcome. The Cox proportional hazard model was used to examine the influence of various pathological features on the prognosis in different subsites of oral cavity. There were totally 1,383 OCSCC patients enrolled for final analysis. Perineural invasion had a poor prognosis at the early stage of OCSCC patients especially those with primary at the tongue. In addition, lymphovascular invasion was associated with poor survival at the late stage especially those with primary at the buccal mucosa and the tongue. The impact of pathological features on the survival of OCSCC patients varied in different subsites. Further investigation is warranted to validate our finding in a multicenter study. Grouping the different markers to establish a prognostic scoring system may provide more accurate evaluation of the prognosis in OCSCC patients.

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“…Additionally, there are constraints in repeating RT in case of tumor recurrence or second primary tumors . Patients who are cured with standard therapies also have a significant life‐long risk of developing second primary tumors of the head and neck, which has been associated with poor prognosis . Endoscopic laser resection may cause scarring, depending on the extent of the excision and the surgeon's expertise, which likewise can affect larynx function .…”

Section: Introductionmentioning

confidence: 99%

“…8,9 Patients who are cured with standard therapies also have a significant life-long risk of developing second primary tumors of the head and neck, which has been associated with poor prognosis. [10][11][12] Endoscopic laser resection may cause scarring, depending on the extent of the excision and the surgeon's expertise, which likewise can affect larynx function. 6 In 2013, an estimated 12,260 men and women were to be diagnosed with laryngeal cancer and 3630 were predicted to die of the disease.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy with 3‐(1′‐hexyloxyethyl) pyropheophorbide‐a for early‐stage cancer of the larynx: Phase Ib study

et al. 2015

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BackgroundThe purpose of this study was for us to report results regarding the safety of 3‐(1′‐hexyloxyethyl) pyropheophorbide‐a (HPPH) mediated photodynamic therapy (PDT) in early laryngeal disease, and offer preliminary information on treatment responses.MethodsA single‐institution, phase Ib, open label, noncomparative study of HPPH‐PDT in patients with high‐risk dysplasia, carcinoma in situ, and T1 squamous cell carcinoma (SCC) of the larynx. The primary outcomes were safety and maximum tolerated dose (MTD), and the secondary outcome was response.ResultsTwenty‐nine patients and 30 lesions were treated. The most common adverse event (AE) was transient hoarseness of voice. Severe edema, requiring tracheostomy, was the most serious AE, which occurred in 2 patients within several hours of therapy. The MTD was 100 J/cm2. Patients with T1 SCC seemed to have good complete response rate (82%) to HPPH‐PDT at MTD.ConclusionHPPH‐PDT can be safely used to treat early‐stage laryngeal cancer, with potential efficacy. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 38: E377–E383, 2016

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Survival analysis of patients with oral squamous cell carcinoma with simultaneous second primary tumors

Abstract: Simultaneous SPT is an independent prognostic factor for patients with oral squamous cell carcinoma. Those with simultaneous SPT have poorer survival when compared to those without.

Cited by 19 publications

References 15 publications

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study

Pathological features and their prognostic impacts on oral cavity cancer patients among different subsites – A singe institute’s experience in Taiwan

Photodynamic therapy with 3‐(1′‐hexyloxyethyl) pyropheophorbide‐a for early‐stage cancer of the larynx: Phase Ib study

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