Survival Analysis of Resection of Lung Metastases From Colorectal Cancer

Poce, Roberto Mongil; Navarrete, C. Pagés; Navarrete, José Antonio Ruiz; Fernández, Javier Roca; Sánchez, Ricardo Arrabal; Doménech, Agustín Benítez; Avecilla, A. Fernández de Rota; Bermúdez, J.L. Fernández

doi:10.1016/s1579-2129(09)72154-8

Cited by 5 publications

(2 citation statements)

References 28 publications

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“…PM was associated with low postoperative mortality (0–2.5%) [ 1 , 11 , 14 , 15 , 16 , 17 , 18 ]. For this reason, potential risk factors for mortality could not be assessed.…”

Section: Discussionmentioning

confidence: 99%

Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival

et al. 2022

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Background: Pulmonary metastasectomy (PM) is an established treatment option for selected patients with stage IV solid tumors. The aim of this study was to investigate the feasibility of and survival rate in PM for elderly patients. Methods: We retrospectively analyzed all of the patients who underwent PM with curative intention at our institution. The patients were categorized into two groups: the elderly group (≥70 years old) and the non-elderly group (<70 years old). Results: The elderly group consisted of 222 patients versus 538 patients in the non-elderly group. The median number of resected metastases was 2 ± 3 in the elderly group and 4 ± 5 in the non-elderly group (p < 0.01). No difference in the rate of postoperative complications was observed between the two groups (p = 0.3). The median length of hospital stay in each group was comparable (10 ± 5 vs. 10 ± 4.3 days, p = 0.3). The 5-year survival rate was 67% in the elderly group and 78% in the non-elderly group (p = 0.117). In the univariate analysis, COPD was associated with poor survival in the elderly group (p = 0.002). Conclusion: The resection of pulmonary metastases in elderly patients is safe, is not associated with increased risks of postoperative complication, and the survival benefit is not reduced in selected patients.

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“…PM was associated with low postoperative mortality (0–2.5%) [ 1 , 11 , 14 , 15 , 16 , 17 , 18 ]. For this reason, potential risk factors for mortality could not be assessed.…”

Section: Discussionmentioning

confidence: 99%

Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival

et al. 2022

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“…The frequency of the isolated pulmonary metastases is in the range 1,7% to 11,4% (9)(10)(11)(12)(13)(14). This is explained by the fact that the venous drainage of medium and lower third of the rectum is through lower and medium rectal veins, avoiding the venous system of v.portae and respectively, the liver which is the first filter (13,15,16).…”

mentioning

confidence: 99%

Diagnostics of intrapulmonary metastases from colorectal cancer (literature survey)

Obretenov¹,

Georgieva²

2015

TJS

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The colon cancer is on the first place as etiologic cause for performing pulmonary resection due to pulmonary metastases. The low effectiveness of chemotherapy in case of metastatic progression from colorectal carcinoma is established. Accordingly, the surgical resection is commonly accepted as the only potential therapeutic option. In favour of the good results from surgical treatment is the trend of earlier finding of pulmonary metastases. The metastases diagnostics has important meaning for differentiation from other lung diseases and for the choice of the therapeutic method. The benefits and disadvantages of non-invasive (chest X-ray, CT, lung perfusion scintigraphy, PET and PET/CT, tumor markers) and invasive (bronchoscopy, mediastinoscopy, VATS (video-assisted thoracic surgery, TTNB (trans-thoracic needle biopsy)) methods for diagnosis of intrapulmonary metastases are analyzed. Key words: colorectal cancer, pulmonary metastasesThere are different reports in the scientific literature about the incidence of colorectal carcinoma. According to some authors it is the third most often diagnosed cancer in the world (1-4). The data from P. J Villeneuve and R. S. Sundaresan (5) show that over one million new patients get sick from this insidious disease every year. H. Meulendeld at al. (6) report that 40% of the patients with colorectal carcinoma in Europe are over 75 years of age at the moment of first diagnosis and there are expectations that this number would significantly increase in the next two decades.The colorectal carcinoma in Bulgaria according to the data from 2012 for prevalence is on third place in men and on second place in women and represents 8.6% from all malignant diseases totally for both sexes. The registered new cases are 2772, and 52,7% of them in men. The diagnosis in 42,4% of the patients is set in advanced III and IV stages. The relative 5 -year survival in Bulgaria is 45,0% for men, 45,3% for women and 45,2% totally for both sexes. It is lower than the average for Europe-55,6%. (7). According to summed statistics A. ___________________________

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Optimal timing for the resection of pulmonary metastases in patients with colorectal cancer

Yamada¹,

Ozawa²,

Onozato³

et al. 2020

Medicine

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This study aims to clarify the surgical treatment time of pulmonary metastasis in patients with colorectal cancer. Early relapse after resection of pulmonary metastasis is often encountered when the interval from the detection of pulmonary metastasis to pulmonary metastasectomy was short. In this retrospective analysis, data of patients with colorectal cancer who underwent surgical treatment of pulmonary metastasis at the Gunma Prefectural Cancer Center, Gunma, from April 2001 through September 2018 were evaluated. The patients were divided into 2 groups. We examined the interval period from the diagnosis of pulmonary metastasis to pulmonary metastasectomy. This period was divided into every 3 months, and the prognosis of each group was compared with clarify the appropriate timing of pulmonary metastasectomy. The primary endpoints were 5-year overall survival and recurrence-free survival rates. The most significant difference was observed when the cutoff value was 9 months (5-year recurrence-free survival 45.8% vs 85.6%, P < .01). No significant difference was found in any background factors between the 2 groups. Twenty-five patients (34.7%) experienced recurrence after pulmonary metastasectomy. The most common site of recurrence was the lung (48%). Among the 12 cases of recurrence of pulmonary metastasis, 11 cases belonged to the <9 months group. A multivariable survival analysis found that the interval period of <9 months was a significant predictor of recurrence. Our study suggests that clinical follow-up for 9 months prior pulmonary metastasectomy in colorectal patients would improve the prognosis.

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Survival Analysis of Resection of Lung Metastases From Colorectal Cancer

Cited by 5 publications

References 28 publications

Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival

Lung Resections for Elderly Patients with Lung Metastases: A Comparative Study of the Postoperative Complications and Overall Survival

Diagnostics of intrapulmonary metastases from colorectal cancer (literature survey)

Optimal timing for the resection of pulmonary metastases in patients with colorectal cancer

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